Search Results - "Meskauskas, Arturas"

Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway by Belew, Ashton Trey, Meskauskas, Arturas, Musalgaonkar, Sharmishtha, Advani, Vivek M., Sulima, Sergey O., Kasprzak, Wojciech K., Shapiro, Bruce A., Dinman, Jonathan D.

“…Programmed −1 ribosomal frameshift (−1 PRF) signals redirect translating ribosomes to slip back one base on messenger RNAs. Although well characterized in…”
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rRNA Pseudouridylation Defects Affect Ribosomal Ligand Binding and Translational Fidelity from Yeast to Human Cells by Jack, Karen, Bellodi, Cristian, Landry, Dori M., Niederer, Rachel O., Meskauskas, Arturas, Musalgaonkar, Sharmishtha, Kopmar, Noam, Krasnykh, Olya, Dean, Alison M., Thompson, Sunnie R., Ruggero, Davide, Dinman, Jonathan D.

“…How pseudouridylation (Ψ), the most common and evolutionarily conserved modification of rRNA, regulates ribosome activity is poorly understood. Medically, Ψ is…”
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Crystal structure of the 80S yeast ribosome by Jenner, Lasse, Melnikov, Sergey, de Loubresse, Nicolas Garreau, Ben-Shem, Adam, Iskakova, Madina, Urzhumtsev, Alexandre, Meskauskas, Arturas, Dinman, Jonathan, Yusupova, Gulnara, Yusupov, Marat

“…► The first crystal structure of a eukaryotic 80S ribosome is described. ► Techniques for isolation of 80S ribosomes from Saccharomyces cerevisiae are…”
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Ribosome Binding to a 5′ Translational Enhancer Is Altered in the Presence of the 3′ Untranslated Region in Cap-Independent Translation of Turnip Crinkle Virus by STUPINA, Vera A, XUEFENG YUAN, MESKAUSKAS, Arturas, DINMAN, Jonathan D, SIMON, Anne E

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Ribosomal Protein L3: Gatekeeper to the A Site by Meskauskas, Arturas, Dinman, Jonathan D.

“…Ribosomal protein L3 (L3) is an essential and indispensable component for formation of the peptidyltransferase center. Atomic resolution ribosome structures…”
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Ribosomal protein L3 functions as a 'rocker switch' to aid in coordinating of large subunit-associated functions in eukaryotes and Archaea by Meskauskas, Arturas, Dinman, Jonathan D

“…Although ribosomal RNAs (rRNAs) comprise the bulk of the ribosome and carry out its main functions, ribosomal proteins also appear to play important structural…”
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The 3' proximal translational enhancer of Turnip crinkle virus binds to 60S ribosomal subunits by Stupina, Vera A, Meskauskas, Arturas, McCormack, John C, Yingling, Yaroslava G, Shapiro, Bruce A, Dinman, Jonathan D, Simon, Anne E

“…During cap-dependent translation of eukaryotic mRNAs, initiation factors interact with the 5' cap to attract ribosomes. When animal viruses translate in a…”
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Identification of Functionally Important Amino Acids of Ribosomal Protein L3 by Saturation Mutagenesis by Meskauskas, Arturas, Petrov, Alexey N., Dinman, Jonathan D.

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Yeast ribosomal protein L10 helps coordinate tRNA movement through the large subunit by Petrov, Alexey N, Meskauskas, Arturas, Roshwalb, Sara C, Dinman, Jonathan D

“…Yeast ribosomal protein L10 (E. coli L16) is located at the center of a topological nexus that connects many functional regions of the large subunit. This…”
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Structure/function analysis of yeast ribosomal protein L2 by Meskauskas, Arturas, Russ, Johnathan R, Dinman, Jonathan D

“…Ribosomal protein L2 is a core element of the large subunit that is highly conserved among all three kingdoms. L2 contacts almost every domain of the large…”
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The 9-A solution: how mRNA pseudoknots promote efficient programmed -1 ribosomal frameshifting by Plant, Ewan P, Jacobs, Kristi L Muldoon, Harger, Jason W, Meskauskas, Arturas, Jacobs, Jonathan L, Baxter, Jennifer L, Petrov, Alexey N, Dinman, Jonathan D

“…There is something special about mRNA pseudoknots that allows them to elicit efficient levels of programmed -1 ribosomal frameshifting. Here, we present a…”
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Enhanced purity, activity and structural integrity of yeast ribosomes purified using a general chromatographic method by Leshin, Jonathan A., Rakauskaitė, Rasa, Dinman, Jonathan, Meskauskas, Arturas

“…One of the major challenges facing researchers working with eukaryotic ribosomes lies in their lability relative to their eubacterial and archael counterparts…”
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Ribosomal protein L5 helps anchor peptidyl-tRNA to the P-site in Saccharomyces cerevisiae by MESKAUSKAS, ARTURAS, DINMAN, JONATHAN D.

“…Our previous demonstration that mutants of 5S rRNA called mof9 can specifically alter efficiencies of programmed ribosomal frameshifting (PRF) suggested a role…”
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Ribosomal Protein L3: Influence on Ribosome Structure and Function by Petrov, Alexey, Meskauskas, Arturas, Dinman, Jonathan D.

“…Early studies demonstrated roles for ribosomal protein L3 in peptidyltransferase center formation and the ability of cells to propagate viruses. More recent…”
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Structural and functional analysis of 5S rRNA in Saccharomyces cerevisiae by Kiparisov, S, Petrov, A, Meskauskas, A, Sergiev, P.V, Dontsova, O.A, Dinman, J.D

“…5S rRNA extends from the central protuberance of the large ribosomal subunit, through the A-site finger, and down to the GTPase-associated center. Here, we…”
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Delayed rRNA Processing Results in Significant Ribosome Biogenesis and Functional Defects by Meskauskas, Arturas, Baxter, Jennifer L., Carr, Edward A., Yasenchak, Jason, Gallagher, Jennifer E. G., Baserga, Susan J., Dinman, Jonathan D.

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molecular clamp ensures allosteric coordination of peptidyltransfer and ligand binding to the ribosomal A-site by Meskauskas, Arturas, Dinman, Jonathan D

“…Although the ribosome is mainly comprised of rRNA and many of its critical functions occur through RNA-RNA interactions, distinct domains of ribosomal proteins…”
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Eukaryotic rpL10 drives ribosomal rotation by Sulima, Sergey O, Gülay, Suna P, Anjos, Margarida, Patchett, Stephanie, Meskauskas, Arturas, Johnson, Arlen W, Dinman, Jonathan D

“…Ribosomes transit between two conformational states, non-rotated and rotated, through the elongation cycle. Here, we present evidence that an internal loop in…”
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Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency by Mailliot, Justine, Garreau de Loubresse, Nicolas, Yusupova, Gulnara, Meskauskas, Arturas, Dinman, Jonathan D., Yusupov, Marat

“…The ribosome has been described as a ribozyme in which ribosomal RNA is responsible for peptidyl-transferase reaction catalysis. The W255C mutation of the…”
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The 3' end of Turnip crinkle virus contains a highly interactive structure including a translational enhancer that is disrupted by binding to the RNA-dependent RNA polymerase by Yuan, Xuefeng, Shi, Kerong, Meskauskas, Arturas, Simon, Anne E

“…Precise temporal control is needed for RNA viral genomes to translate sufficient replication-required products before clearing ribosomes and initiating…”
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