Search Results - "Meshulam, Tova"

Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study by Thomas, Dylan D, Stockman, Mary-Catherine, Yu, Liqun, Meshulam, Tova, McCarthy, Ashley C, Ionson, Annaliese, Burritt, Nathan, Deeney, Jude, Cabral, Howard, Corkey, Barbara, Istfan, Nawfal, Apovian, Caroline M

“…Medium chain triglycerides (MCT) have unique metabolic properties which may improve insulin sensitivity (Si) and beta cell function but data in humans are…”
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Extracellular Redox Regulation of Intracellular Reactive Oxygen Generation, Mitochondrial Function and Lipid Turnover in Cultured Human Adipocytes by Jones, IV, Albert R, Meshulam, Tova, Oliveira, Marcus F, Burritt, Nathan, Corkey, Barbara E

“…Many tissues play an important role in metabolic homeostasis and the development of diabetes and obesity. We hypothesized that the circulating redox metabolome…”
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Adipose Stroma Accelerates the Invasion and Escape of Human Breast Cancer Cells from an Engineered Microtumor by Dance, Yoseph W., Meshulam, Tova, Seibel, Alex J., Obenreder, Mackenzie C., Layne, Matthew D., Nelson, Celeste M., Tien, Joe

“…Introduction Approximately 20–25% of human breast tumors are found within an adipose, rather than fibrous, stroma. Adipose stroma is associated with an…”
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Adipose Cells Induce Escape from an Engineered Human Breast Microtumor Independently of their Obesity Status by Dance, Yoseph W., Obenreder, Mackenzie C., Seibel, Alex J., Meshulam, Tova, Ogony, Joshua W., Lahiri, Nikhil, Pacheco-Spann, Laura, Radisky, Derek C., Layne, Matthew D., Farmer, Stephen R., Nelson, Celeste M., Tien, Joe

“…Introduction Obesity is associated with increased breast cancer incidence, recurrence, and mortality. Adipocytes and adipose-derived stem cells (ASCs), two…”
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Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity by Meshulam, Tova, Breen, Michael R., Liu, Libin, Parton, Robert G., Pilch, Paul F.

“…Mice and humans lacking functional caveolae are dyslipidemic and have reduced fat stores and smaller fat cells. To test the role of caveolins/caveolae in…”
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Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity by Simard, Jeffrey R, Meshulam, Tova, Pillai, Biju K, Kirber, Michael T, Brunaldi, Kellen, Xu, Su, Pilch, Paul F, Hamilton, James A

“…Ectopic expression of caveolin-1 in HEK293 cells enhances FA sequestration in membranes as measured by a pH-sensitive fluorescent dye (1). We hypothesized that…”
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Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes by Jedrychowski, Mark P, Liu, Libin, Laflamme, Collette J, Karastergiou, Kalypso, Meshulam, Tova, Ding, Shi-Ying, Wu, Yuanyuan, Lee, Mi-Jeong, Gygi, Steven P, Fried, Susan K, Pilch, Paul F

“…Abstract Objective Adipocytes are robust protein secretors, most notably of adipokines, hormone-like polypeptides, which act in an endocrine and paracrine…”
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Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity by Simard, Jeffrey R., Meshulam, Tova, Pillai, Biju K., Kirber, Michael T., Brunaldi, Kellen, Xu, Su, Pilch, Paul F., Hamilton, James A.

“…Ectopic expression of caveolin-1 in HEK293 cells enhances FA sequestration in membranes as measured by a pH-sensitive fluorescent dye (1). We hypothesized that…”
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A Simplified New Assay for Assessment of Fungal Cell Damage with the Tetrazolium Dye, (2,3)-bis-(2-Methoxy-4-Nitro-5-Sulphenyl)-(2H)-Tetrazolium-5-Carboxanilide (XTT) by Meshulam, Tova, Levitz, Stuart M., Christin, Laurent, Diamond, Richard D.

“…Studies of antimycotic host defenses have been limited by the paucity of rapid, reproducible quantitative assays for fungal cell damage. Prior studies defined…”
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Abstract P1-04-08: Exosomes from primary breast adipocytes induce immune exhaustion in triple negative breast cancer by Jafari, Naser, Kolla, Manohar, Pompa, Isabella, Meshulam, Tova, Junior, Miguel Batista, Denis, Gerald V

“…Abstract Patients with triple negative breast cancer (TNBC), who have co-morbid type 2 diabetes (T2D), have higher risk for metastatic disease and…”
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Human Platelets Damage Aspergillus fumigatus Hyphae and May Supplement Killing by Neutrophils by CHRISTIN, L, WYSONG, D. R, MESHULAM, T, HASTEY, R, SIMONS, E. R, DIAMOND, R. D

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Acute carbohydrate overfeeding: a redox model of insulin action and its impact on metabolic dysfunction in humans by Istfan, Nawfal, Hasson, Brooke, Apovian, Caroline, Meshulam, Tova, Yu, Liqun, Anderson, Wendy, Corkey, Barbara E

“…A role for fat overfeeding in metabolic dysfunction in humans is commonly implied in the literature. Comparatively less is known about acute carbohydrate…”
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Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes by Jafari, Naser, Kolla, Manohar, Meshulam, Tova, Shafran, Jordan S, Qiu, Yuhan, Casey, Allison N, Pompa, Isabella R, Ennis, Christina S, Mazzeo, Carla S, Rabhi, Nabil, Farmer, Stephen R, Denis, Gerald V

“…Obesity and metabolic diseases, such as insulin resistance and type 2 diabetes (T2D), are associated with metastatic breast cancer in postmenopausal women…”
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Adipocyte-Origin Exosomes Regulate Breast Cancer Aggressiveness in Obesity and Metabolic Disease by Jafari, Naser, Kolla, Manohar, Meshulam, Tova, Shafran, Jordan, Qiu, Yuhan, Casey, Allison, Mazzeo, Carla, Rabhi, Nabil, Farmer, Stephen, Denis, Gerald

“…Background: Obesity and metabolic diseases, such as insulin resistance and Type 2 diabetes (T2D), associate with breast cancer progression in post-menopausal…”
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Three-Dimensional Adipocyte Culture as a Model to Study Cachexia-Induced White Adipose Tissue Remodeling by Batista, Jr, Miguel L, Meshulam, Tova, Desevin, Kathleen, Rabhi, Nabil, Farmer, Stephen R

“…Cancer cachexia (CC) presents itself as a syndrome with multiple manifestations, causing a marked multi-organ metabolic imbalance. Recently, cachectic wasting…”
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Metformin relieves oxidative stress and leads to differential modulation of function in key metabolic tissues by Simmons, Amber, Meshulam, Tova, Labad, Laura Nocito, Corkey, Barbara

“…Abstract only Metformin reduces hyperglycemia and hyperlipidemia in people with diabetes. We hypothesized that metformin alters a circulating redox state,…”
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Role of Caveolin-1 and Cholesterol in Transmembrane Fatty Acid Movement by Meshulam, Tova, Simard, Jeffrey R., Wharton, Jonathan, Hamilton, James A., Pilch, Paul F.

“…We have created by transfection a series of HEK 293 cell lines that express varying amounts of caveolin-1 to test the possible effect of this protein on the…”
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Dissociation of Insulin Receptor Expression and Signaling from Caveolin-1 Expression by Wharton, Jonathan, Meshulamy, Tova, Vallega, Gino, Pilch, Paul

“…The presence of cell surface caveolin/caveolae has been postulated to influence the localization, expression levels, and kinase activity of numerous receptors,…”
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Caveolin/Cholesterol Alters the Transport of Long Chain Fatty Acids in Membranes by Meshulam, Tova, Simard, Jeff, Wharton, Jonathan, Hamilton, James A, Pilch, Paul F

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Use of Structure-Based Drug Design Approaches to Obtain Novel Anthranilic Acid Acyl Carrier Protein Synthase Inhibitors by Joseph-McCarthy, Diane, Parris, Kevin, Huang, Adrian, Failli, Amedeo, Quagliato, Dominick, Dushin, Elizabeth Glasfeld, Novikova, Elena, Severina, Elena, Tuckman, Margareta, Petersen, Peter J, Dean, Charles, Fritz, Christian C, Meshulam, Tova, DeCenzo, Maureen, Dick, Larry, McFadyen, Iain J, Somers, William S, Lovering, Frank, Gilbert, Adam M

“…Acyl carrier protein synthase (AcpS) catalyzes the transfer of the 4‘-phosphopantetheinyl group from the coenzyme A to a serine residue in acyl carrier protein…”
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