Search Results - "Meshul, C K"

Impaired glutamate homeostasis and programmed cell death in a chronic MPTP mouse model of Parkinson's disease by Meredith, G.E., Totterdell, S., Beales, M., Meshul, C.K.

“…The pathogenesis of Parkinson's disease is not fully understood, but there is evidence that excitotoxic mechanisms contribute to the pathology. However, data…”
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Dopaminergic and behavioral correlates of progressive lesioning of the nigrostriatal pathway with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by Goldberg, N.R.S, Haack, A.K, Lim, N.S, Janson, O.K, Meshul, C.K

“…Abstract A number of neurotoxin- and gene-based rodent models of acute neurodegeneration of nigrostriatal dopamine (DA) neurons are used to study Parkinson's…”
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Enriched environment promotes similar neuronal and behavioral recovery in a young and aged mouse model of Parkinson's disease by Goldberg, N.R.S, Haack, A.K, Meshul, C.K

“…Abstract Environmental enrichment has been shown to be neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's…”
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Effect of intermittent washout periods on progressive lesioning of the nigrostriatal pathway with 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by Goldberg, N.R.S, Meshul, C.K

“…Abstract We have previously reported that a progressively increased dose of MPTP over the course of 4 weeks induces the gradual impairment of the nigrostriatal…”
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Time-dependent changes in striatal glutamate synapses following a 6-hydroxydopamine lesion by Meshul, C.K, Emre, N, Nakamura, C.M, Allen, C, Donohue, M.K, Buckman, J.F

“…The goal of this study was to investigate changes in glutamatergic synapses in the striatum of rats at two different time-points following a unilateral…”
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Exercise in an animal model of Parkinson’s disease: Motor recovery but not restoration of the nigrostriatal pathway by Churchill, M.J., Pflibsen, L., Sconce, M.D., Moore, C., Kim, K., Meshul, C.K.

“…•Exercise causes motor recovery in a progressive MPTP animal model of PD.•Motor recovery is not facilitated by restoration of dopamine within the nigrostriatal…”
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Kappa opioid receptor immunoreactivity in the nucleus accumbens and caudate–putamen is primarily associated with synaptic vesicles in axons by Meshul, C.K., McGinty, J.F.

“…A rabbit polyclonal antiserum, raised against a C-terminal oligopeptide of the mouse kappa opioid receptor, was used to localize the cellular distribution of…”
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Time-dependent changes in extracellular glutamate in the rat dorsolateral striatum following a single cocaine injection by McKee, B.L., Meshul, C.K.

“…Acute cocaine administration has been shown to alter dorsal striatal plasticity [Proc Natl Acad Sci USA 87 (1990) 6912; Brain Res Bull 30 (1993) 173] and…”
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l-dopa-induced reversal in striatal glutamate following partial depletion of nigrostriatal dopamine with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by Holmer, H.K., Keyghobadi, M., Moore, C., Meshul, C.K.

“…We have reported that 1 month following acute (20mg/kg×4) or subchronic (30mg/kg/day×7d) administration of the neurotoxin,…”
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A Rat Model of Chronic Pressure-induced Optic Nerve Damage by MORRISON, JOHN C., MOORE, C.G., DEPPMEIER, LISA M.H., GOLD, BRUCE G., MESHUL, CHARLES K., JOHNSON, ELAINE C.

“…To develop unilateral, chronically elevated intraocular pressure in rats, episcleral veins were injected with hypertonic saline and the intraocular pressure…”
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Intervention with exercise restores motor deficits but not nigrostriatal loss in a progressive MPTP mouse model of Parkinson’s disease by Sconce, M.D, Churchill, M.J, Greene, R.E, Meshul, C.K

“…Highlights • Motor and behavioral deficits were restored in mice that volunteered to exercise despite MPTP treatment. • MPTP mice that exercised had a similar…”
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Intervention with 7,8-dihydroxyflavone blocks further striatal terminal loss and restores motor deficits in a progressive mouse model of Parkinson’s disease by Sconce, M.D, Churchill, M.J, Moore, C, Meshul, C.K

“…Highlights • 7,8-DHF intervention blocks further loss of TH within the dorsolateral striatum in a progressive MPTP mouse model of PD. • Intervention with…”
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Alterations in nerve terminal glutamate immunoreactivity in the nucleus accumbens and ventral tegmental area following single and repeated doses of cocaine by KOZELL, L. B, MESHUL, C. K

“…Previous studies have demonstrated that sensitization to repeated doses of cocaine results in prolonged changes in glutamate transmission. However, little is…”
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Differential regulation of the growth-associated proteins GAP-43 and superior cervical ganglion 10 in response to lesions of the cortex and substantia nigra in the adult rat by Hughes-Davis, E.J., Cogen, J.P., Jakowec, M.W., Cheng, H.W., Grenningloh, G., Meshul, C.K., McNeill, T.H.

“…Investigation of the elements underlying synapse replacement after brain injury is essential for predicting the neural compensation that can be achieved after…”
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Cognitive and anxiety-like impairments accompanied by serotonergic ultrastructural and immunohistochemical alterations in early stages of parkinsonism by Leal, P.C., Bispo, J.M.M., Lins, L.C.R.F., Souza, M.F., Gois, A.M., Moore, C., Marchioro, M., Ribeiro, A.M., Silva, R.H., Meshul, C.K., Santos, J.R.

“…•Repeated reserpine treatment induced behavioral and cognitive changes.•Repeated reserpine treatment decreased 5-HT level in the premotor phase of PD.•The…”
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The effects of acute or repeated cocaine administration on nerve terminal glutamate within the rat mesolimbic system by Kozell, L.B, Meshul, C.K

“…Cocaine administration alters glutamate function within several brain regions. Using quantitative electron microscopic immunocytochemistry, the present study…”
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Nuclear and cytoplasmic localization of basic fibroblast growth factor in astrocytes and CA2 hippocampal neurons by Woodward, WR, Nishi, R, Meshul, CK, Williams, TE, Coulombe, M, Eckenstein, FP

“…Fibroblast growth factors (FGFs) are known to stimulate mitogenesis in a variety of non-neuronal cell types and to support the survival in vitro of many…”
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High-dose methamphetamine treatment alters presynaptic GABA and glutamate immunoreactivity by Burrows, K.B., Meshul, C.K.

“…The goal of this study was to determine if high-dose methamphetamine treatment altered presynaptic immunoreactivity for the amino acid neurotransmitters GABA…”
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Haloperidol-induced morphological changes in striatum are associated with glutamate synapses by Meshul, C K, Stallbaumer, R K, Taylor, B, Janowsky, A

“…Sub-chronic treatment with the typical neuroleptic, haloperidol (0.5 mg/kg/d, s.c.), but not the atypical neuroleptic, clozapine (35 mg/kg/day, s.c.), causes…”
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Correlation of vacuous chewing movements with morphological changes in rats following 1-year treatment with haloperidol by MESHUL, C. K, ANDREASSEN, O. A, ALLEN, C, JØRGENSEN, H. A

“…Long-term treatment with the typical antipsychotic drug, haloperidol, can lead to a sometimes irreversible motor disorder, tardive dyskinesia (TD). It has been…”
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