Search Results - "Meshel, Tsipi"

Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer by Liubomirski, Yulia, Lerrer, Shalom, Meshel, Tsipi, Rubinstein-Achiasaf, Linor, Morein, Dina, Wiemann, Stefan, Körner, Cindy, Ben-Baruch, Adit

“…The tumor microenvironment (TME) plays key roles in promoting disease progression in the aggressive triple-negative subtype of breast cancer (TNBC;…”
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Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition by Soria, Gali, Ofri-Shahak, Maya, Haas, Ilana, Yaal-Hahoshen, Neora, Leider-Trejo, Leonor, Leibovich-Rivkin, Tal, Weitzenfeld, Polina, Meshel, Tsipi, Shabtai, Esther, Gutman, Mordechai, Ben-Baruch, Adit

“…The inflammatory chemokines CCL2 (MCP-1) & CCL5 (RANTES) and the inflammatory cytokines TNFα & IL-1β were shown to contribute to breast cancer development and…”
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Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer by Liubomirski, Yulia, Lerrer, Shalom, Meshel, Tsipi, Morein, Dina, Rubinstein-Achiasaf, Linor, Sprinzak, David, Wiemann, Stefan, Körner, Cindy, Ehrlich, Marcelo, Ben-Baruch, Adit

“…Stromal cells and pro-inflammatory cytokines play key roles in promoting the aggressiveness of triple-negative breast cancers (TNBC; Basal/Basal-like). In our…”
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Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots by Shulman, Ziv, Cohen, Shmuel J, Roediger, Ben, Kalchenko, Vyacheslav, Jain, Rohit, Grabovsky, Valentin, Klein, Eugenia, Shinder, Vera, Stoler-Barak, Liat, Feigelson, Sara W, Meshel, Tsipi, Nurmi, Susanna M, Goldstein, Itamar, Hartley, Olivier, Gahmberg, Carl G, Etzioni, Amos, Weninger, Wolfgang, Ben-Baruch, Adit, Alon, Ronen

“…Endothelium-presented chemokines are critical for the entry of lymphocytes into tissues. Alon and colleagues show that transendothelial migration, but not…”
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The Beta Subunit of Hemoglobin (HBB2/HBB) Suppresses Neuroblastoma Growth and Metastasis by Maman, Shelly, Sagi-Assif, Orit, Yuan, Weirong, Ginat, Ravit, Meshel, Tsipi, Zubrilov, Inna, Keisari, Yona, Lu, Weiyue, Lu, Wuyuan, Witz, Isaac P

“…Soluble pulmonary factors have been reported to be capable of inhibiting the viability of cancer cells that metastasize to the lung, but the molecular identity…”
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Inflammatory Factors of the Tumor Microenvironment Induce Plasticity in Nontransformed Breast Epithelial Cells: EMT, Invasion, and Collapse of Normally Organized Breast Textures by Leibovich-Rivkin, Tal, Liubomirski, Yulia, Bernstein, Biana, Meshel, Tsipi, Ben-Baruch, Adit

“…Abstract Nontransformed breast epithelial cells that are adjacent to tumor cells are constantly exposed to tumor necrosis factor-α (TNFα) and interleukin-1β…”
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Chemokine axes in breast cancer: factors of the tumor microenvironment reshape the CCR7‐driven metastatic spread of luminal‐A breast tumors by Weitzenfeld, Polina, Kossover, Olga, Körner, Cindy, Meshel, Tsipi, Wiemann, Stefan, Seliktar, Dror, Legler, Daniel F., Ben‐Baruch, Adit

“…Luminal‐A‐specific regulation of the CCR7‐CCL21 axis in cancer LN metastasis Chemokine axes have been shown to mediate site‐specific metastasis in breast…”
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CXCL10 promotes invasion-related properties in human colorectal carcinoma cells by ZIPIN-ROITMAN, Adi, MESHEL, Tsipi, SAGI-ASSIF, Orit, SHALMON, Bruria, AVIVI, Camila, PFEFFER, Raphael M, WITZ, Isaac P, BEN-BARUCH, Adit

“…CXCL10 was recently shown to exert antimalignancy functions by influencing the tumor microenvironment. Here, we have taken a different approach, investigating…”
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The Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Breast Cancer Are Regulated by N-Linked Glycosylation-Dependent Activation of STAT3 and STAT1 by Erlichman, Nofar, Meshel, Tsipi, Baram, Tamir, Abu Raiya, Alaa, Horvitz, Tamar, Ben-Yaakov, Hagar, Ben-Baruch, Adit

“…PD-L1 has been characterized as an inhibitory immune checkpoint, leading to the suppression of potential anti-tumor immune activities in many cancer types. In…”
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The melanoma brain metastatic microenvironment: aldolase C partakes in shaping the malignant phenotype of melanoma cells – a case of inter‐tumor heterogeneity by Izraely, Sivan, Ben‐Menachem, Shlomit, Sagi‐Assif, Orit, Meshel, Tsipi, Malka, Sapir, Telerman, Alona, Bustos, Matias A., Ramos, Romela Irene, Pasmanik‐Chor, Metsada, Hoon, Dave S. B., Witz, Isaac P.

“…The melanoma‐microglia cross‐talk upregulates the expression of aldolase C (ALDOC) in melanoma cells from several patients. The response of melanoma cells from…”
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The metastatic microenvironment: Brain-residing melanoma metastasis and dormant micrometastasis by Izraely, Sivan, Sagi-Assif, Orit, Klein, Anat, Meshel, Tsipi, Tsarfaty, Galia, Pasmanik-Chor, Metsada, Nahmias, Clara, Couraud, Pierre-Olivier, Ateh, Eugene, Bryant, Joseph L., Hoon, Dave S.B., Witz, Isaac P.

“…Brain metastasis occurs frequently in melanoma patients with advanced disease whereby the prognosis is dismal. The underlying mechanisms of melanoma brain…”
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The metastatic microenvironment: Claudin‐1 suppresses the malignant phenotype of melanoma brain metastasis by Izraely, Sivan, Sagi‐Assif, Orit, Klein, Anat, Meshel, Tsipi, Ben‐Menachem, Shlomit, Zaritsky, Assaf, Ehrlich, Marcelo, Prieto, Victor G., Bar‐Eli, Menashe, Pirker, Christine, Berger, Walter, Nahmias, Clara, Couraud, Pierre‐Olivier, Hoon, Dave S.B., Witz, Isaac P.

“…Brain metastases occur frequently in melanoma patients with advanced disease whereby the prognosis is dismal. The underlying mechanisms of melanoma brain…”
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Co-Inflammatory Roles of TGFβ1 in the Presence of TNFα Drive a Pro-inflammatory Fate in Mesenchymal Stem Cells by Lerrer, Shalom, Liubomirski, Yulia, Bott, Alexander, Abnaof, Khalid, Oren, Nino, Yousaf, Afsheen, Körner, Cindy, Meshel, Tsipi, Wiemann, Stefan, Ben-Baruch, Adit

“…High plasticity is a hallmark of mesenchymal stem cells (MSCs), and as such, their differentiation and activities may be shaped by factors of their…”
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Breast Cancer: Coordinated Regulation of CCL2 Secretion by Intracellular Glycosaminoglycans and Chemokine Motifs by Lebel-Haziv, Yaeli, Meshel, Tsipi, Soria, Gali, Yeheskel, Adva, Mamon, Elad, Ben-Baruch, Adit

“…Abstract The chemokine CCL2 (MCP-1) has been identified as a prominent tumor-promoting factor in breast cancer. The major source for CCL2 is in the tumor…”
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Regeneration Enhances Metastasis: A Novel Role for Neurovascular Signaling in Promoting Melanoma Brain Metastasis by Prakash, Roshini, Izraely, Sivan, Thareja, Nikita S, Lee, Rex H, Rappaport, Maya, Kawaguchi, Riki, Sagi-Assif, Orit, Ben-Menachem, Shlomit, Meshel, Tsipi, Machnicki, Michal, Ohe, Shuichi, Hoon, Dave S, Coppola, Giovanni, Witz, Isaac P, Carmichael, S Thomas

“…Neural repair after stroke involves initiation of a cellular proliferative program in the form of angiogenesis, neurogenesis, and molecular growth signals in…”
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Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells by Morein, Dina, Rubinstein-Achiasaf, Linor, Brayer, Hadar, Dorot, Orly, Pichinuk, Edward, Ben-Yaakov, Hagar, Meshel, Tsipi, Pasmanik-Chor, Metsada, Ben-Baruch, Adit

“…Chronic inflammation promotes cancer progression by affecting the tumor cells and their microenvironment. Here, we demonstrate that a continuous stimulation…”
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The Vicious Cycle of Melanoma-Microglia Crosstalk: Inter-Melanoma Variations in the Brain-Metastasis-Promoting IL-6/JAK/STAT3 Signaling Pathway by Izraely, Sivan, Ben-Menachem, Shlomit, Malka, Sapir, Sagi-Assif, Orit, Bustos, Matias A, Adir, Orit, Meshel, Tsipi, Chelladurai, Maharrish, Ryu, Suyeon, Ramos, Romela I, Pasmanik-Chor, Metsada, Hoon, Dave S B, Witz, Isaac P

“…Previous studies from our lab demonstrated that the crosstalk between brain-metastasizing melanoma cells and microglia, the macrophage-like cells of the…”
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A Possible Role for CXCR4 and Its Ligand, the CXC Chemokine Stromal Cell-Derived Factor-1, in the Development of Bone Marrow Metastases in Neuroblastoma by Geminder, Hila, Sagi-Assif, Orit, Goldberg, Lilach, Meshel, Tsipi, Rechavi, Gideon, Witz, Isaac P, Ben-Baruch, Adit

“…The homing of hemopoietic stem cells to the bone marrow is mediated by specific interactions occurring between CXCR4, which is expressed on hemopoietic stem…”
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Epidermal Growth Factor and Estrogen Act by Independent Pathways to Additively Promote the Release of the Angiogenic Chemokine CXCL8 by Breast Tumor Cells by Haim, Karin, Weitzenfeld, Polina, Meshel, Tsipi, Ben-Baruch, Adit

“…The tumor microenvironment contains multiple cancer-supporting factors, whose joint activities promote malignancy. Here, we show that epidermal growth factor…”
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Chemotherapy Shifts the Balance in Favor of CD8+ TNFR2+ TILs in Triple-Negative Breast Tumors by Baram, Tamir, Erlichman, Nofar, Dadiani, Maya, Balint-Lahat, Nora, Pavlovski, Anya, Meshel, Tsipi, Morzaev-Sulzbach, Dana, Gal-Yam, Einav Nili, Barshack, Iris, Ben-Baruch, Adit

“…Triple-negative breast cancer (TNBC) is primarily treated via chemotherapy; in parallel, efforts are made to introduce immunotherapies into TNBC treatment…”
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