Effect of chronic administration of chlorpromazine on electrical parameters of command neurons in edible snail

Electrophysiological experiments showed that chronic administration of neuroleptic chlorpromazine depolarized plasma membrane and decreased the threshold of action potential generation in command neuron of defense behavior of edible snail and motoneurons of pneumostome closure reflex. The effects of...

Full description

Saved in:

Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 139; no. 3; pp. 272 - 274
Main Authors:	Gainutdinova, T Kh, Meshchaninova, A V, Andrianov, V V, Silant'eva, D I, Gainutdinov, Kh L
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-03-2005
Subjects:	Action Potentials - drug effects Animals Antipsychotic Agents - pharmacology Chlorpromazine - pharmacology Electrophysiology Helix (Snails) - physiology Microelectrodes Neurons - drug effects Neurons - physiology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Electrophysiological experiments showed that chronic administration of neuroleptic chlorpromazine depolarized plasma membrane and decreased the threshold of action potential generation in command neuron of defense behavior of edible snail and motoneurons of pneumostome closure reflex. The effects of chlorpromazine on electrical parameters of the identified neurons can be explained by its serotonin-depleting action.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0268-4