Search Results - "Meseck, Marcia"

The Novel Role of Tyrosine Kinase Inhibitor in the Reversal of Immune Suppression and Modulation of Tumor Microenvironment for Immune-Based Cancer Therapies by OZAO-CHOY, Junko, GE MA, KAO, Johnny, WANG, George X, MESECK, Marcia, SUNG, Max, SCHWARTZ, Myron, DIVINO, Celia M, PAN, Ping-Ying, CHEN, Shu-Hsia

“…In tumor-bearing hosts, myeloid-derived suppressor cells (MDSC) and T regulatory cells (Treg) play important roles in immune suppression, the reversal of which…”
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Development and biophysical characterization of a humanized FSH-blocking monoclonal antibody therapeutic formulated at an ultra-high concentration by Rojekar, Satish, Pallapati, Anusha R, Gimenez-Roig, Judit, Korkmaz, Funda, Sultana, Farhath, Sant, Damini, Haeck, Clement M, Macdonald, Anne, Kim, Se-Min, Rosen, Clifford J, Barak, Orly, Meseck, Marcia, Caminis, John, Lizneva, Daria, Yuen, Tony, Zaidi, Mone

“…Highly concentrated antibody formulations are oftentimes required for subcutaneous, self-administered biologics. Here, we report the development of a unique…”
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Evaluation of a clinical-grade, cryopreserved, ex vivo-expanded stem cell product from cryopreserved primary umbilical cord blood demonstrates multilineage hematopoietic engraftment in mouse xenografts by Schaniel, Christoph, Papa, Luena, Meseck, Marcia L., Kintali, Manisha, Djedaini, Mansour, Zangui, Mahtab, Iancu-Rubin, Camelia, Hoffman, Ronald

“…Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapy for a wide range of malignant and genetic disorders of the…”
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Myeloid-Derived Suppressor Cells as a Vehicle for Tumor-Specific Oncolytic Viral Therapy by EISENSTEIN, Samuel, COAKLEY, Brian A, PAN, Ping-Ying, BRILEY-SAEBO, Karen, GE MA, CHEN, Hui-Ming, MESECK, Marcia, WARD, Stephen, DIVINO, Celia, WOO, Savio, CHEN, Shu-Hsia

“…One of the several impediments to effective oncolytic virus therapy of cancer remains a lack of tumor-specific targeting. Myeloid-derived suppressor cells…”
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Foxo1 mediates insulin action on apoC-III and triglyceride metabolism by Altomonte, Jennifer, Cong, Lin, Harbaran, Sonal, Richter, Anja, Xu, Jing, Meseck, Marcia, Dong, Hengjiang Henry

“…The apolipoprotein apoC-III plays an important role in plasma triglyceride metabolism. It is predominantly produced in liver, and its hepatic expression is…”
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Elevated Vascular Endothelial Growth Factor Production in Islets Improves Islet Graft Vascularization by Zhang, Nan, Richter, Anja, Suriawinata, Jenny, Harbaran, Sonal, Altomonte, Jennifer, Cong, Lin, Zhang, Haojiang, Song, Keying, Meseck, Marcia, Bromberg, Jonathan, Dong, Hengjiang

“…Elevated Vascular Endothelial Growth Factor Production in Islets Improves Islet Graft Vascularization Nan Zhang 1 , Anja Richter 1 , Jenny Suriawinata 1 ,…”
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289 PGV-001: a phase 1 trial of a personalized neoantigen peptide vaccine for the treatment of malignancies in the adjuvant setting by Marron, Thomas, Kodysh, Julia, Rubinsteyn, Alex, Finnigan, John, Blazquez, Ana, Saxena, Mansi, Meseck, Marcia, O’Donnell, Timothy, Delbeau, Daniela, Galsky, Matthew, Doroshow, Deborah, Miles, Brett, Misiukiewicz, Krysztof, Irie, Hanna, Tiersten, Amy, Parekh, Samir, Posner, Marshall, Wolf, Andrea, Mandeli, John, Hammerbacher, Jeffrey, Donovan, Michael, Brody, Rachel, Gnjatic, Sacha, Schadt, Eric, Friedlander, Philip, Bhardwaj, Nina

“…BackgroundThe efficacy of T cell directed immunotherapies relies on adequate priming of T cells to tumor-specific neoantigens, which some studies have…”
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Increased Hepatic Levels of the Insulin Receptor Inhibitor, PC-1/NPP1, Induce Insulin Resistance and Glucose Intolerance by HENGJIANG DONG, MADDUX, Betty A, ALTOMONTE, Jennifer, MESECK, Marcia, ACCILI, Domenico, TERKELTAUB, Robert, JOHNSON, Kristen, YOUNGREN, Jack F, GOLDFINE, Ira D

“…Increased Hepatic Levels of the Insulin Receptor Inhibitor, PC-1/NPP1, Induce Insulin Resistance and Glucose Intolerance Hengjiang Dong 1 , Betty A. Maddux 2 ,…”
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OX40 Ligation Enhances Primary and Memory Cytotoxic T Lymphocyte Responses in an Immunotherapy for Hepatic Colon Metastases by Pan, Ping-Ying, Zang, Yunjuan, Weber, Kaare, Meseck, Marcia L., Chen, Shu-Hsia

“…Previously, we showed that the eradication of murine hepatic metastatic colon carcinomas was achieved by using a combination therapy with adenovirus-mediated…”
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Myeloid derived suppressor cells (MDSCs) assume an M1 phenotype when exposed to vesicular stomatitis virus, synergistically treating tumors by Eisenstein, Samuel, MD, Coakley, Brian A., MD, Ma, Ge, MD, Meseck, Marcia, BA, Woo, Savio, PhD, Pan, Ping-Ying, PhD, Chen, Shu-Hsia, PhD, Divino, Celia, MD, FACS

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Auto-regulated Hepatic Insulin Gene Expression in Type 1 Diabetic Rats by Chen, Ruihuan, Meseck, Marcia L., Woo, Savio L.C.

“…Paradigms of insulin gene therapy for type 1 diabetes should incorporate vigorous control for insulin gene expression to be effective in correcting…”
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Basal Insulin Gene Expression Significantly Improves Conventional Insulin Therapy in Type 1 Diabetic Rats by HENGJIANG DONG, ALTOMONTE, Jennifer, MORRAL, Nuria, MESECK, Marcia, THUNG, Swan N, WOOL, Savio L. C

“…Basal Insulin Gene Expression Significantly Improves Conventional Insulin Therapy in Type 1 Diabetic Rats Hengjiang Dong 1 , Jennifer Altomonte 1 , Nuria…”
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Dendritic Cell Vaccines by Sabado, Rachel Lubong, Meseck, Marcia, Bhardwaj, Nina

“…Exploitation of the patient's own immune system to induce antitumor immune responses using dendritic cell (DC) immunotherapy has been established in early…”
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Atezolizumab plus personalized neoantigen vaccination (PGV001) in patients with urothelial cancer by Anker, Jonathan Forrest, Saxena, Mansi, Kodysh, Julia, O'Donnell, Timothy, Meseck, Marcia, Hapanowicz, Olivia, Niglio, Scot Anthony, Shah, Hardik R., Kinoshita, Yayoi, Brody, Rachel, Rubinsteyn, Alex, Sebra, Robert P., Bhardwaj, Nina, Galsky, Matt D.

“…597 Background: Most patients (pts) with urothelial cancer (UC) treated with immune checkpoint inhibitors (ICIs) do not respond. Given that features associated…”
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FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice by Kamagate, Adama, Qu, Shen, Perdomo, German, Su, Dongming, Kim, Dae Hyun, Slusher, Sandra, Meseck, Marcia, Dong, H Henry

“…Excessive production of triglyceride-rich VLDL is attributable to hypertriglyceridemia. VLDL production is facilitated by microsomal triglyceride transfer…”
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Abstract CT173: PGV-001: A phase I trial of a multipeptide personalized neoantigen vaccine in the adjuvant setting by Kodysh, Julia, Marron, Thomas, Rubinsteyn, Alex, O'Donnell, Tim, Finnigan, John, Blazquez, Ana, Saxena, Mansi, Meseck, Marcia, Friedlander, Philip, Bhardwaj, Nina

“…Abstract Background: Mutation-derived tumor antigens (MTAs) arise as a result of somatic mutations, such as nucleotide substitutions and small…”
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CTIM-10. PHASE 1 TRIAL OF PERSONALIZED NEOANTIGEN VACCINES IN COMBINATION WITH STANDARD CARE TO TREAT GLIOBLASTOMA by Bozkus, Cansu Cimen, Kodysh, Julia, Cheng, Szu Jung, Cheng, Samantha, Rubinsteyn, Alex, O’Donnell, Tim, Saxena, Mansi, Akturk, Guray, Meseck, Marcia, Yong, Raymund, Losic, Bojan, Mandeli, John, Kim, Ryung S, Gnjatic, Sacha, Bhardwaj, Nina, Hormigo, Adilia

“…Abstract The tumor microenvironment (TME) of glioblastoma (GBM) is populated by cells that foster immunosuppression. Reversing immunosuppression and promoting…”
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First-in-class humanized FSH blocking antibody targets bone and fat by Gera, Sakshi, Sant, Damini, Haider, Shozeb, Korkmaz, Funda, Kuo, Tan-Chun, Mathew, Mehr, Perez-Pena, Helena, Xie, Honglin, Chend, Hao, Batista, Rogerio, Ma, Kejun, Cheng, Zhen, Hadelia, Elina, Robinson, Cemre, Macdonald, Anne, Miyashita, Sari, Williams, Anthony, Jebian, Gregory, Miyashita, Hirotaka, Gumerova, Anisa, Ievleva, Kseniia, Smith, Pinar, He, Jiahuan, Ryu, Vitaly, DeMambro, Victoria, Quinn, Matthew A., Meseck, Marcia, Kim, Se-Min, Kumar, T. Rajendra, Iqbal, Jameel, New, Maria I., Lizneva, Daria, Rosen, Clifford J., Hsueh, Aaron J., Yuen, Tony, Zaidi, Mone

“…Blocking the action of FSH genetically or pharmacologically in mice reduces body fat, lowers serum cholesterol, and increases bone mass, making an anti-FSH…”
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Combined Vaccination with NY-ESO-1 Protein, Poly-ICLC, and Montanide Improves Humoral and Cellular Immune Responses in Patients with High-Risk Melanoma by Pavlick, Anna, Blazquez, Ana B, Meseck, Marcia, Lattanzi, Michael, Ott, Patrick A, Marron, Thomas U, Holman, Rose Marie, Mandeli, John, Salazar, Andres M, McClain, Christopher B, Gimenez, Gustavo, Balan, Sreekumar, Gnjatic, Sacha, Sabado, Rachel Lubong, Bhardwaj, Nina

“…Given its ability to induce both humoral and cellular immune responses, NY-ESO-1 has been considered a suitable antigen for a cancer vaccine. Despite promising…”
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Optimizing a therapeutic humanized follicle‐stimulating hormone–blocking antibody formulation by protein thermal shift assay by Sant, Damini, Rojekar, Satish, Gera, Sakshi, Pallapati, Anusha R., Gimenez‐Roig, Judit, Kuo, Tan‐Chun, Padilla, Ashley, Korkmaz, Funda, Cullen, Liam, Chatterjee, Jiya, Shelly, Eleanor, Meseck, Marcia, Miyashita, Sari, Macdonald, Anne, Sultana, Farhath, Barak, Orly, Ryu, Vitaly, Kim, Se‐Min, Robinson, Cemre, Rosen, Clifford J., Caminis, John, Lizneva, Daria, Haider, Shozeb, Yuen, Tony, Zaidi, Mone

“…Biopharmaceutical products are formulated using several Food and Drug Administration (FDA) approved excipients within the inactive ingredient limit to maintain…”
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