Search Results - "Mesaki, K."

Inequities in multi-gene hereditary cancer testing: lower diagnostic yield and higher VUS rate in individuals who identify as Hispanic, African or Asian and Pacific Islander as compared to European by Ndugga-Kabuye, Mesaki K., Issaka, Rachel B.

“…The identification of germline pathogenic/likely pathogenic (P/LP) variants in cancer predisposition genes can guide treatment and management decisions for the…”
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Complications of the Low Phenylalanine Diet for Patients with Phenylketonuria and the Benefits of Increased Natural Protein by McWhorter, Nicole, Ndugga-Kabuye, Mesaki K, Puurunen, Marja, Ernst, Sharon L

“…Phenylketonuria (PKU) is an inherited disorder in which phenylalanine (Phe) is not correctly metabolized leading to an abnormally high plasma Phe concentration…”
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CRISPR/Cas9-Based Transcriptional Activation of Endogenous IL-10 Gene in the Donor Lung for Transplantation by Mesaki, K., Silverberg, O., Juvet, S., Guan, Z., Bai, X., Martinu, T., Cypel, M., Liu, M., Keshavjee, S.

“…Gene therapy of donor lungs has shown promise in lung transplantation (LTx). The discovery of the clustered regularly interspaced palindromic repeats…”
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Clinical Characteristics & Outcomes of Restrictive CLAD After Bilateral Living-Donor Lobar Lung Transplantation by Mesaki, K, Miyoshi, K, Namura, S, Kurosaki, T, Otani, S, Sugimoto, S, Yamane, M, Miyoshi, S, Oto, T

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Warm Retrograde Perfusion Can Remove More Fat from Lung Grafts with Fat Embolism in a Porcine Donor Model by Irie, M, Otani, S, Kurosaki, T, Shikatani, Y, Mesaki, K, Hashimoto, K, Tanaka, S, Miyahara, K, Ohki, T, Miyoshi, K, Sugimoto, S, Yamane, M, Miyoshi, S, Oto, T

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(56) A Preclinical Study of CRISPR Porcine Cell Gene Editing Combined with IL-10 Gene Delivery for Donor Lung Immunomodulation by Yoshiyasu, N., Mesaki, K., Guan, Z., Juvet, S., Kleinstiver, B., Cypel, M., Liu, M., Keshavjee, S.

“…Genetically modified donor organs are capable of suppressing graft rejections by providing long-lasting immunomodulation. However, the time constraints imposed…”
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Proof-of-Concept Study of Oxalate-Consuming Synthetic Biotic Medicine SYNB8802 in Enteric Hyperoxaluria after Roux-en-Y Surgery: PO2026 by Puurunen, Marja, Denney, William, Ndugga-Kabuye, Mesaki K., Marsh, Andrew, Lubkowicz, David, Kurtz, Caroline B., Brennan, Aoife M., Riese, Richard

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Multiplex Targeted Epigenome Editing Utilizing CRSPR/Cas9 for Potent Anti-Inflammatory Gene Therapy in Lung Transplant by Mesaki, K., Juvet, S., Guan, Z., Hu, J., Davidson, A.R., Cypel, M., Liu, M., Keshavjee, S.

“…Flexible modulation of gene expressions in the donor lung holds great promise in lung transplant. We hypothesized that activation of multiple anti-inflammatory…”
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CRISPR/Cas9-Mediated Epigenome Editing of the IL-10 Gene for Targeted Whole Organ Gene Therapy for Lung Transplant by Mesaki, K., Juvet, S., Guan, Z., Hu, J., Davidson, A.R., Cypel, M., Liu, M., Keshavjee, S.

“…Anti-inflammatory and immunomodulatory gene therapy has shown promise in lung transplant. CRISPR/Cas9 technology unleashed the possibility of making gene…”
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(55) Genetic Engineering for Combined Early and Long-Term Immunomodulation in the Donor Lung after Transplantation by Mesaki, K., Juvet, S., Yeung, J., Mangat, H., Dickie, C., Guan, Z., Shathasivam, P., Hu, J., Davidson, A., Kleinstiver, B., Cypel, M., Liu, M., Keshavjee, S.

“…Early and late graft injury in the donor lung significantly limits the donor pool and outcomes in lung transplantation. Donor lungs engineered to exert both…”
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(356) - ABO Genotype and its Relation on Histo-Blood Antigen Expression and Regeneration Following Removal - Potential Significance in ABO Incompatible Transplantation by Wang, A., Mesaki, K., Yune, J., Zhang, Y., Montagne, J., Lima, T., Loesch Siebiger, G., Yamanashi, K., Garza, G., Rahfeld, P., Cserti, C., Aversa, M., Withers, S., Kizhakkedathu, J., Liu, M., Juvet, S., Keshavjee, S., Cypel, M.

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(555) - CRISPR Genome Engineering in Donor Lung During Cyclic EVLP with 10°C Preservation: Usage of TorEx Lung Perfusion System by Yoshiyasu, N., Mariscal, A., Salvador, A., Hough, O., Yamamoto, H., Gokhale, H., Shan, H., Chen, M., Guan, Z., Suzuki, Y., Yao, Y., Mesaki, K., Nagoya, A., Juvet, S., Waddell, T.K., Liu, M., Cypel, M., Keshavjee, S.

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(8) - CRISPR-Cas Genome Editing in Ex Vivo Human Lungs by Mesaki, K., Yamamoto, H., Juvet, S., Yeung, J., Guan, Z., Yao, Y., Chen, M., Gokhale, H., Shan, H., Wang, A., Wilson, G., Mariscal, A., Hu, J., Davidson, A., Kleinstiver, B., Cypel, M., Liu, M., Keshavjee, S.

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Derepression of the IL-10 Gene by CRISPR-Cas Genome Editing as a Therapeutic Strategy for Persistent Immunomodulation of Donor Lungs for Transplantation by Mesaki, K., Juvet, S., Yeung, J., Ivakine, E., Guan, Z., Shathasivam, P., Akhter, A., Wilson, G., Kleinstiver, B., Hu, J., Davidson, A., Cypel, M., Liu, M., Keshavjee, S.

“…Anti-rejection immunosuppression is a persistent challenge in lung transplantation. We envisioned creating less immunogenic donor organs to obviate or reduce…”
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(1276) Development of Mini-Circuit Ex-Vivo Lung Perfusion to Accelerate Human Lung Translational Research by Yamamoto, H., Mariscal, A., Hough, O., Mesaki, K., Taniguchi, D., Gokhale, H., Chen, M., Shan, H., Suzuki, Y., Yoshiyasu, N., Yamanashi, K., Aujla, T., Bojic, D., Sorbo, L. Del, Yeung, J., Liu, M., Cypel, M., Keshavjee, S.

“…Ex-vivo lung perfusion (EVLP) has significantly advanced translational research. Studies using human donor lungs declined for clinical transplantation or…”
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CRISPR-Mediated IL-10 Gene Activation as a Novel Gene Therapeutic Strategy in Lung Transplantation by Mesaki, K., Silverberg, O., Guan, Z., Juvet, S., Martinu, T., Cypel, M., Waddell, T., Liu, M., Keshavjee, S.

“…Lung transplantation (LTx) is life-saving treatment for end-stage respiratory failure. Our ultimate goal is to improve the outcome of LTx by upregulating the…”
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(506) - Overexpression of SOCS3 Attenuates Tracheal Allograft Rejection in the Early Phase After Murine Heterotopic Tracheal Transplantation by the Inhibition of Th1 Response by Mesaki, K., Sugimoto, S., Watanabe, H., Fujisawa, M., Yoshimura, T., Kurosaki, T., Otani, S., Yamane, M., Toyooka, S., Matsukawa, A., Oto, T.

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(1183) - Experience of Using mTOR Inhibitor in Lung Transplant at Recipients With Lymphangioleiomyomatosis by Kurosaki, T., Otani, S., Sugimoto, S., Miyoshi, K., Yamamoto, H., Tanaka, S., Shikatani, Y., Mesaki, K., Hashimoto, K., Yamane, M., Toyooka, S., Oto, T.

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CRISPR Genome Engineering in Donor Lung During Cyclic EVLP with 10°C Preservation: Usage of TorEx Lung Perfusion System by Yoshiyasu, N., Mariscal, A., Salvador, A., Hough, O., Yamamoto, H., Gokhale, H., Shan, H., Chen, M., Guan, Z., Suzuki, Y., Yao, Y., Mesaki, K., Nagoya, A., Juvet, S., Waddell, T.K., Liu, M., Cypel, M., Keshavjee, S.

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10μW/cm2-Class High Power Density Planar Si-Nanowire Thermoelectric Energy Harvester Compatible with CMOS-VLSI Technology by Tomita, M., Oba, S., Himeda, Y., Yamato, R., Shima, K., Kumada, T., Xu, M., Takezawa, H., Mesaki, K., Tsuda, K., Hashimoto, S., Zhan, T., Zhang, H., Kamakura, Y., Suzuki, Y., Inokawa, H., Ikeda, H., Matsukawa, T., Matsuki, T., Watanabe, T.

“…A best benchmark of Si-nanowire (NW) thermoelectric (TE) power generator has been achieved by our proposed planar device architecture compatible with CMOS…”
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