Search Results - "Merwin, J"

PRISM 3: expanded prediction of natural product chemical structures from microbial genomes by Skinnider, Michael A, Merwin, Nishanth J, Johnston, Chad W, Magarvey, Nathan A

“…Microbial natural products represent a rich resource of pharmaceutically and industrially important compounds. Genome sequencing has revealed that the majority…”
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Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences by Skinnider, Michael A., Johnston, Chad W., Gunabalasingam, Mathusan, Merwin, Nishanth J., Kieliszek, Agata M., MacLellan, Robyn J., Li, Haoxin, Ranieri, Michael R. M., Webster, Andrew L. H., Cao, My P. T., Pfeifle, Annabelle, Spencer, Norman, To, Q. Huy, Wallace, Dan Peter, Dejong, Chris A., Magarvey, Nathan A.

“…Novel antibiotics are urgently needed to address the looming global crisis of antibiotic resistance. Historically, the primary source of clinically used…”
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DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products by Merwin, Nishanth J., Mousa, Walaa K., Dejong, Chris A., Skinnider, Michael A., Cannon, Michael J., Li, Haoxin, Dial, Keshav, Gunabalasingam, Mathusan, Johnston, Chad, Magarvey, Nathan A.

“…Microbial natural products represent a rich resource of evolved chemistry that forms the basis for the majority of pharmacotherapeutics. Ribosomally…”
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Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining by Skinnider, Michael A., Johnston, Chad W., Edgar, Robyn E., Dejong, Chris A., Merwin, Nishanth J., Rees, Philip N., Magarvey, Nathan A.

“…Microbial natural products are an evolved resource of bioactive small molecules, which form the foundation of many modern therapeutic regimes. Ribosomally…”
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Strain partitioning in ultra-fine grained medium-manganese transformation induced plasticity steel by Gibbs, P.J., De Cooman, B.C., Brown, D.W., Clausen, B., Schroth, J.G., Merwin, M.J., Matlock, D.K.

“…A 7.1-Mn 0.1-C transformation-induced plasticity steel was intercritically annealed at 600°C and 650°C for 168h. Ultra-fine-grained microstructures with…”
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Global analysis of prokaryotic tRNA-derived cyclodipeptide biosynthesis by Skinnider, Michael A, Johnston, Chad W, Merwin, Nishanth J, Dejong, Chris A, Magarvey, Nathan A

“…Among naturally occurring small molecules, tRNA-derived cyclodipeptides are a class that have attracted attention for their diverse and desirable biological…”
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Limitations and Challenges in Modeling Diseases Involving Spinal Motor Neuron Degeneration in Vitro by Bucchia, Monica, Merwin, Samantha J, Re, Diane B, Kariya, Shingo

“…Pathogenic conditions involving degeneration of spinal motor neurons (MNs), such as amyotrophic lateral sclerosis, sarcopenia, and spinal cord injury, mostly…”
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The Currently Available Literature on Inpatient Foodservices: Systematic Review and Critical Appraisal by Dijxhoorn, Dorian N., Mortier, Merwin J.M.J., van den Berg, Manon G.A., Wanten, Geert J.A.

“…An adequate hospital foodservice is important to optimize protein and energy intake and to maintain or improve a patient’s nutritional status. Key elements…”
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Successful Treatment of Lymphocytic Colitis With a Honey Lavage by Mortier, Merwin J M J, Laheij, Robert J F

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Longitudinal transcriptomic analysis of mouse sciatic nerve reveals pathways associated with age‐related muscle pathology by Comfort, Nicole, Gade, Meethila, Strait, Madeleine, Merwin, Samantha J., Antoniou, Daphne, Parodi, Chiara, Marcinczyk, Lina, Jean‐Francois, Lea, Bloomquist, Tessa R., Memou, Anna, Rideout, Hardy J., Corti, Stefania, Kariya, Shingo, Re, Diane B.

“…Background Sarcopenia, the age‐associated decline in skeletal muscle mass and strength, has long been considered a disease of muscle only, but accumulating…”
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Austenite Stability Effects on Tensile Behavior of Manganese-Enriched-Austenite Transformation-Induced Plasticity Steel by GIBBS, P. J, DE MOOR, E, MERWIN, M. J, CLAUSEN, B, SPEER, J. G, MATLOCK, D. K

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Effect of chitosan on epithelial permeability and structure by Dodane, Valérie, Amin Khan, M., Merwin, June R.

“…Numerous studies have shown that chitosan, a mucoadhesive polymer, is a potential enhancer for transmucosal drug delivery. To further understand the mechanisms…”
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Involvement of endothelial PECAM-1/CD31 in angiogenesis by DeLisser, HM, Christofidou-Solomidou, M, Strieter, RM, Burdick, MD, Robinson, CS, Wexler, RS, Kerr, JS, Garlanda, C, Merwin, JR, Madri, JA, Albelda, SM

“…The adhesive interactions of endothelial cells with each other and the adhesion receptors that mediate these interactions are probably of fundamental…”
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Antibiotics and specialized metabolites from the human microbiota by Mousa, Walaa K, Athar, Bilal, Merwin, Nishanth J, Magarvey, Nathan A

“…Covering: 2000 to 2017Decades of research on human microbiota have revealed much of their taxonomic diversity and established their direct link to health and…”
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Organophosphate neurotoxicity to the voluntary motor system on the trail of environment-caused amyotrophic lateral sclerosis: the known, the misknown, and the unknown by Merwin, Samantha J., Obis, Teresa, Nunez, Yanelli, Re, Diane B.

“…Amyotrophic lateral sclerosis (ALS) is the most common adult-onset paralytic disorder. It is characterized by progressive degeneration of the motor neurons…”
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Austenite stabilization through manganese enrichment by De Moor, Emmanuel, Matlock, David K., Speer, John G., Merwin, Matthew J.

“…A model is proposed to predict austenite stabilization through manganese partitioning between ferrite and austenite. The model predicts retained austenite…”
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Austenite Stability Effects on Tensile Behavior of Manganese-Enriched-Austenite Transformation-Induced Plasticity Steel by Gibbs, P. J., De Moor, E., Merwin, M. J., Clausen, B., Speer, J. G., Matlock, D. K.

“…Manganese enrichment of austenite during prolonged intercritical annealing was used to produce a family of transformation-induced plasticity (TRIP) steels with…”
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Austenite Reconstruction Elucidates Prior Grain Size Dependence of Toughness in a Low Alloy Steel by Ranger, Chasen, Tari, Vahid, Farjami, Susan, Merwin, Matthew J., Germain, Lionel, Rollett, Anthony

“…Texture and grain size distribution of the austenite phase at high temperature have distinct effects on the subsequent transformed microstructure and…”
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Yttrium oxide nanoparticles prevent photoreceptor death in a light-damage model of retinal degeneration by Mitra, Rajendra N., Merwin, Miles J., Han, Zongchao, Conley, Shannon M., Al-Ubaidi, Muayyad R., Naash, Muna I.

“…Photoreceptor (PR) cells are prone to accumulation of reactive oxygen species (ROS) and oxidative stress. An imbalance between the production of ROS and…”
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Reply to the Commentary by Lotti M. and Moretto A. “Organophosphate neurotoxicity to the voluntary motor system on the trail of environment-caused amyotrophic lateral sclerosis: the known, the misknown and the unknown by Merwin, Samantha J., Obis, Teresa, Nunez, Yanelli, Re, Diane B.

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