Search Results - "Mertz, Tony"

APOBEC3A is a prominent cytidine deaminase in breast cancer by Cortez, Luis M, Brown, Amber L, Dennis, Madeline A, Collins, Christopher D, Brown, Alexander J, Mitchell, Debra, Mertz, Tony M, Roberts, Steven A

“…APOBEC cytidine deaminases are the second-most prominent source of mutagenesis in sequenced tumors. Previous studies have proposed that APOBEC3B (A3B) is the…”
Get full text

APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication by Hoopes, James I., Cortez, Luis M., Mertz, Tony M., Malc, Ewa P., Mieczkowski, Piotr A., Roberts, Steven A.

“…APOBEC family cytidine deaminases have recently been implicated as powerful mutators of cancer genomes. How APOBECs, which are ssDNA-specific enzymes, gain…”
Get full text

Her2 amplification, Rel-A, and Bach1 can influence APOBEC3A expression in breast cancer cells by Dennis, Madeline, Hurley, Alyssa, Bray, Nicholas, Cordero, Cameron, Ilagan, Jose, Mertz, Tony M, Roberts, Steven A

“…APOBEC-induced mutations occur in 50% of sequenced human tumors, with APOBEC3A (A3A) being a major contributor to mutagenesis in breast cancer cells. The…”
Get full text

APOBEC-Induced Mutagenesis in Cancer by Mertz, Tony M, Collins, Christopher D, Dennis, Madeline, Coxon, Margo, Roberts, Steven A

“…The initiation, progression, and relapse of cancers often result from mutations occurring within somatic cells. Consequently, processes that elevate mutation…”
Get full text

Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity by Mertz, Tony M., Sharma, Sushma, Chabes, Andrei, Shcherbakova, Polina V.

“…Significance Mutations affecting replicative DNA polymerases δ (Polδ) and ε (Polε) are linked to sporadic and hereditary colorectal cancer and sporadic…”
Get full text

Single-stranded DNA binding proteins influence APOBEC3A substrate preference by Brown, Amber L., Collins, Christopher D., Thompson, Secily, Coxon, Margo, Mertz, Tony M., Roberts, Steven A.

“…The cytidine deaminase, APOBEC3A (A3A), is a prominent source of mutations in multiple cancer types. These APOBEC-signature mutations are non-uniformly…”
Get full text

Genetic inhibitors of APOBEC3B-induced mutagenesis by Mertz, Tony M, Rice-Reynolds, Elizabeth, Nguyen, Ly, Wood, Anna, Cordero, Cameron, Bray, Nicholas, Harcy, Victoria, Vyas, Rudri K, Mitchell, Debra, Lobachev, Kirill, Roberts, Steven A

“…The cytidine deaminases APOBEC3A (A3A) and APOBEC3B (A3B) are prominent mutators of human cancer genomes. However, tumor-specific genetic modulators of…”
Get full text

A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stability by Kadyrova, Lyudmila Y, Mertz, Tony M, Zhang, Yu, Northam, Matthew R, Sheng, Ziwei, Lobachev, Kirill S, Shcherbakova, Polina V, Kadyrov, Farid A

“…Mutations are a major driving force of evolution and genetic disease. In eukaryotes, mutations are produced in the chromatin environment, but the impact of…”
Get full text

Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity by Mertz, Tony M, Harcy, Victoria, Roberts, Steven A

“…The ability of all organisms to copy their genetic information via DNA replication is a prerequisite for cell division and a biological imperative of life. In…”
Get full text

DNA polymerase ζ-dependent lesion bypass in Saccharomyces cerevisiae is accompanied by error-prone copying of long stretches of adjacent DNA by Kochenova, Olga V, Daee, Danielle L, Mertz, Tony M, Shcherbakova, Polina V

“…Translesion synthesis (TLS) helps cells to accomplish chromosomal replication in the presence of unrepaired DNA lesions. In eukaryotes, the bypass of most…”
Get full text

The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway by Rosenbaum, Joel C., Bonilla, Braulio, Hengel, Sarah R., Mertz, Tony M., Herken, Benjamin W., Kazemier, Hinke G., Pressimone, Catherine A., Ratterman, Timothy C., MacNary, Ellen, De Magis, Alessio, Kwon, Youngho, Godin, Stephen K., Van Houten, Bennett, Normolle, Daniel P., Sung, Patrick, Das, Subha R., Paeschke, Katrin, Roberts, Steven A., VanDemark, Andrew P., Bernstein, Kara A.

“…Accurate DNA replication is essential for genomic stability and cancer prevention. Homologous recombination is important for high-fidelity DNA damage tolerance…”
Get full text

DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures by Northam, Matthew R, Moore, Elizabeth A, Mertz, Tony M, Binz, Sara K, Stith, Carrie M, Stepchenkova, Elena I, Wendt, Kathern L, Burgers, Peter M J, Shcherbakova, Polina V

“…DNA polymerase ζ (Pol ζ) and Rev1 are key players in translesion DNA synthesis. The error-prone Pol ζ can also participate in replication of undamaged DNA when…”
Get full text

cancer-associated DNA polymerase δ variant modeled in yeast causes a catastrophic increase in genomic instability by Daee, Danielle L, Mertz, Tony M, Shcherbakova, Polina V

“…Accurate DNA synthesis by the replicative DNA polymerases α, δ, and ε is critical for genome stability in eukaryotes. In humans, over 20 SNPs were reported…”
Get full text

Histone deacetylase complexes promote trinucleotide repeat expansions by Debacker, Kim, Frizzell, Aisling, Gleeson, Olive, Kirkham-McCarthy, Lucy, Mertz, Tony, Lahue, Robert S

“…Expansions of DNA trinucleotide repeats cause at least 17 inherited neurodegenerative diseases, such as Huntington's disease. Expansions can occur at…”
Get full text

An impaired ubiquitin-proteasome system increases APOBEC3A abundance by Coxon, Margo, Dennis, Madeline A, Dananberg, Alexandra, Collins, Christopher D, Wilson, Hannah E, Meekma, Jordyn, Savenkova, Marina I, Ng, Daniel, Osbron, Chelsea A, Mertz, Tony M, Goodman, Alan G, Duttke, Sascha H, Maciejowski, John, Roberts, Steven A

“…Apolipoprotein B messenger RNA (mRNA) editing enzyme, catalytic polypeptide-like (APOBEC) cytidine deaminases cause genetic instability during cancer…”
Get full text

The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions by Bonilla, Braulio, Brown, Alexander J, Hengel, Sarah R, Rapchak, Kyle S, Mitchell, Debra, Pressimone, Catherine A, Fagunloye, Adeola A, Luong, Thong T, Russell, Reagan A, Vyas, Rudri K, Mertz, Tony M, Zaher, Hani S, Mosammaparast, Nima, Malc, Ewa P, Mieczkowski, Piotr A, Roberts, Steven A, Bernstein, Kara A

“…Three-methyl cytosine (3meC) are toxic DNA lesions, blocking base pairing. Bacteria and humans express members of the AlkB enzymes family, which directly…”
Get full text

DNA polymerase [zeta]-dependent lesion bypass in Saccharomyces cerevisiae is accompanied by error-prone copying of long stretches of adjacent DNA by Kochenova, Olga V, Daee, Danielle L, Mertz, Tony M, Shcherbakova, Polina V

“…Translesion synthesis (TLS) helps cells to accomplish chromosomal replication in the presence of unrepaired DNA lesions. In eukaryotes, the bypass of most…”
Get full text

Postreplication Repair Inhibits CAG · CTG Repeat Expansions in Saccharomyces cerevisiae by Daee, Danielle L., Mertz, Tony, Lahue, Robert S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Colon cancer-associated mutator DNA polymerase d variant causes expansion of dNTP pools increasing its own infidelity by Mertz, Tony M, Sharma, Sushma, Chabes, Andrei, Shcherbakova, Polina V

“…Defects in DNA polymerases ... (Pol...) and ... (Pol...) cause hereditary colorectal cancer and have been implicated in the etiology of some sporadic…”
Get full text

Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase δ mutation in human cells by Mertz, T M, Baranovskiy, A G, Wang, J, Tahirov, T H, Shcherbakova, P V

“…Mutations in the POLD1 and POLE genes encoding DNA polymerases δ (Polδ) and ɛ (Polɛ) cause hereditary colorectal cancer (CRC) and have been found in many…”
Get full text