Search Results - "Mertz, David"

Engineering cell heterogeneity into organs-on-a-chip by Mertz, David R, Ahmed, Tasdiq, Takayama, Shuichi

“…Organ-on-a-chip development is an application that will benefit from advances in cell heterogeneity characterization because these culture models are intended…”
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Collagen Type II enhances chondrogenic differentiation in agarose-based modular microtissues by Annamalai, Ramkumar Tiruvannamalai, Mertz, David R, Daley, Ethan L.H, Stegemann, Jan P

“…Graphical Abstract Collagen Type II enhances chondrogenic differentiation in agarose-based modular microtissues Ramkumar Tiruvannamalai Annamalai, David Mertz,…”
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Triple-negative breast cancer cells invade adipocyte/preadipocyte-encapsulating geometrically inverted mammary organoids by Mertz, David R, Parigoris, Eric, Sentosa, Jason, Lee, Ji-Hoon, Lee, Soojung, Kleer, Celina G, Luker, Gary, Takayama, Shuichi

“…Abstract This paper describes the manufacture of geometrically inverted mammary organoids encapsulating primary mammary preadipocytes and adipocytes. Material…”
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Determining the mechanisms behind distribution variability in small molecule pharmaceuticals using 3D spheroid tissues by Mertz, David, Li, Siwei, Luker, Kathy, Luker, Gary, Sun, Duxin, Takayama, Shuichi

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Correlative analysis to define patient profiles associated with manufacturing and clinical endpoints in relapsed/refractory multiple myeloma (RRMM) patients treated with idecabtagene vicleucel (ide-cel; bb2121), an anti-BCMA CAR T cell therapy by Rytlewski, Julie, Fuller, Jaymes, Mertz, David R., Freeman, Ciara, Manier, Salomon, Shah, Nina, Campbell, Timothy Brandon

“…8021 Background: The anti-BCMA autologous CAR T cell therapy ide-cel has achieved deep and durable responses in RRMM patients (Munshi, N Engl J Med 2021)…”
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P-019: Correlative analysis to define patient profiles associated with manufacturing and clinical endpoints in relapsed/refractory multiple myeloma patients treated with idecabtagene vicleucel (ide-cel) by Rytlewski, Julie, Fuller, Jaymes, Mertz, David, Freeman, Ciara, Manier, Salomon, Shah, Nina, Campbell, Timothy

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Multi-cellular engineered living systems: building a community around responsible research on emergence by Sample, Matthew, Boulicault, Marion, Allen, Caley, Bashir, Rashid, Hyun, Insoo, Levis, Megan, Lowenthal, Caroline, Mertz, David, Montserrat, Nuria, Palmer, Megan J, Saha, Krishanu, Zartman, Jeremiah

“…Ranging from miniaturized biological robots to organoids, multi-cellular engineered living systems (M-CELS) pose complex ethical and societal challenges. Some…”
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Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity by Hu, Xiao, Liu, Xikui, Moisan, Jacques, Wang, Yahong, Lesch, Charles A., Spooner, Chauncey, Morgan, Rodney W., Zawidzka, Elizabeth M., Mertz, David, Bousley, Dick, Majchrzak, Kinga, Kryczek, Ilona, Taylor, Clarke, Van Huis, Chad, Skalitzky, Don, Hurd, Alexander, Aicher, Thomas D., Toogood, Peter L., Glick, Gary D., Paulos, Chrystal M., Zou, Weiping, Carter, Laura L.

“…RORγt is the key transcription factor controlling the development and function of CD4 + Th17 and CD8 + Tc17 cells. Across a range of human tumors, about 15% of…”
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Quantifying Nanoscale Properties of Engineered Virus Capsids for Malaria Vaccines by Jin, Albert J., Mertz, David, Liao, Hsien-Shun, Johri, Aanchal, Torres, Luis, Wu, Yimin, Narum, David

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Cancer Cell Invasion of Mammary Organoids with Basal‐In Phenotype by Parigoris, Eric, Lee, Soojung, Mertz, David, Turner, Madeleine, Liu, Amy Y., Sentosa, Jason, Djomehri, Sabra, Chang, Hao Chen, Luker, Kathryn, Luker, Gary, Kleer, Celina G., Takayama, Shuichi

“…This paper describes mammary organoids with a basal‐in phenotype where the basement membrane is located on the interior surface of the organoid. A key…”
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Basal‐In Phenotypes: Cancer Cell Invasion of Mammary Organoids with Basal‐In Phenotype (Adv. Healthcare Mater. 4/2021) by Parigoris, Eric, Lee, Soojung, Mertz, David, Turner, Madeleine, Liu, Amy Y., Sentosa, Jason, Djomehri, Sabra, Chang, Hao Chen, Luker, Kathryn, Luker, Gary, Kleer, Celina G., Takayama, Shuichi

“…Article number 2000810 by Shuichi Takayama and co‐workers describes the basal‐in phenotype of organotypic structures formed from MCF10A cells, in which a…”
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Regulation of CD4+ T cell activation and effector function by the histone acetyltransferase Myst1 (IRM6P.662) by Carson, William, Mertz, David, Cavassani, Karen, Mukherjee, Sumanta, Harissa, Batoul, Kroetz, Danielle, Schaller, Matthew, Dou, Yali, Kunkel, Steven

“…Abstract Chromatin remodeling events are central molecular mechanisms that serve to govern CD4+ T cell function through regulation of gene accessibility. Myst1…”
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Abstract 565: RORγ agonists regulate immune checkpoint receptors to enhance anti-tumor immunity by Hu, Xiao, Liu, Xikui, Moisan, Jacques, Paulos, Chrystal, Wang, Yahong, Spooner, Chauncey, Lesch, Charles, Morgan, Rodney, Mertz, David, Bousley, Dick, Taylor, Clarke, Van Huis, Chad, Skalitzky, Don, Aicher, Thomas, Toogood, Peter, Carter, Laura

“…Abstract As the master transcription factor for Type 17 T cells, RORγt activates a program of gene expression associated with enhancing effector function and…”
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Abstract 565: ROR agonists regulate immune checkpoint receptors to enhance anti-tumor immunity by Hu, Xiao, Liu, Xikui, Moisan, Jacques, Paulos, Chrystal, Wang, Yahong, Spooner, Chauncey, Lesch, Charles, Morgan, Rodney, Mertz, David, Bousley, Dick, Taylor, Clarke, Van Huis, Chad, Skalitzky, Don, Aicher, Thomas, Toogood, Peter, Carter, Laura

“…As the master transcription factor for Type 17 T cells, RORt activates a program of gene expression associated with enhancing effector function and overcoming…”
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Abstract 4273: RORγ agonists as a novel immunotherapy approach for cancer by Hu, Xiao, Moisan, Jacques, Lesch, Charles, Wang, Yahong, Liu, Xikui, Morgan, Rodney, Mertz, David, Sanchez, Brian, Bousley, Dick, Taylor, Clark, Van Huis, Chad, Aicher, Thomas, Toogood, Peter, Zou, Weiping, Glick, Gary, Carter, Laura L.

“…Abstract Agents that enhance activation or release suppression of the immune system could form the basis of new treatments for cancer. RORγt is the key…”
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Phylogeny, Diversity, and Ecology of the Ammonoid Superfamily Acanthoceratoidea Through the Cenomanian and Turonian by Mertz, David A.A

“…Both increased extinction and decreased origination, caused by rising oceanic anoxia and decreased provincialism, respectively, have been proposed as the cause…”
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Women and AIDS: the ethics of exaggerated harm by Mertz, David, Sushinsky, Mary Ann, Schüklenk, Udo

“…This article examines the way in which some biomedical ethicists have constructed sexually transmitted AIDS as a significant threat to women's health. We…”
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The Mathematical Demography of the California Condor Population by Mertz, David B.

“…This paper applies demographic methods devised by Leslie (1966) to the population biology of the California condor. The methods permit evaluation of the…”
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Text processing with Python by Mertz, David

“…Text processing is a fascinating field in computer science with numerous algorithms. This area is very attractive to researchers. Its applications vary widely,…”
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RORgamma agonists enhance survival and memory of type 17 T cells and improve anti-tumor activity by Hu, Xiao, Moisan, Jacques, Majchrzak, Kinga, Lesch, Chuck, Wang, Yahong, Sanchez, Brian, Liu, Xikui, Morgan, Rodney, Mertz, David, Bousley, Dick, van Huis, Chad, Skalitzky, Don, Taylor, Clarke, Aicher, Thomas, Toogood, Peter, Zou, Weiping, Glick, Gary, Paulos, Chrystal, Carter, Laura

“…BackgroundEnhancing tumor-directed immune responses has emerged as an important therapeutic approach to many cancers. Th17/Tc17 cells can mediate robust…”
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