Search Results - "Mertens, Fredrik"

The impact of translocations and gene fusions on cancer causation by Mitelman, Felix, Johansson, Bertil, Mertens, Fredrik

“…Chromosome aberrations, in particular translocations and their corresponding gene fusions, have an important role in the initial steps of tumorigenesis; at…”
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Gene fusions in soft tissue tumors: Recurrent and overlapping pathogenetic themes by Mertens, Fredrik, Antonescu, Cristina R., Mitelman, Felix

“…Gene fusions have been described in approximately one‐third of soft tissue tumors (STT); of the 142 different fusions that have been reported, more than half…”
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Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics by Doyle, Leona A, Vivero, Marina, Fletcher, Christopher DM, Mertens, Fredrik, Hornick, Jason L

“…Solitary fibrous tumor (SFT) is composed of spindled to ovoid cells in a patternless architecture with prominent stromal collagen and hemangiopericytoma-like…”
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Deep sequencing of myxoinflammatory fibroblastic sarcoma by Arbajian, Elsa, Hofvander, Jakob, Magnusson, Linda, Mertens, Fredrik

“…Myxoinflammatory fibroblastic sarcoma (MIFS) has recurrent genetic features in the form of a translocation t(1;10)(p22‐31;q24‐25), BRAF gene fusions, and/or an…”
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Signatures of copy number alterations in human cancer by Steele, Christopher D., Abbasi, Ammal, Islam, S. M. Ashiqul, Bowes, Amy L., Khandekar, Azhar, Haase, Kerstin, Hames-Fathi, Shadi, Ajayi, Dolapo, Verfaillie, Annelien, Dhami, Pawan, McLatchie, Alex, Lechner, Matt, Light, Nicholas, Shlien, Adam, Malkin, David, Feber, Andrew, Proszek, Paula, Lesluyes, Tom, Mertens, Fredrik, Flanagan, Adrienne M., Tarabichi, Maxime, Van Loo, Peter, Alexandrov, Ludmil B., Pillay, Nischalan

“…Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-related processes of replication stress, mitotic errors, spindle…”
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In-depth Genetic Analysis of Sclerosing Epithelioid Fibrosarcoma Reveals Recurrent Genomic Alterations and Potential Treatment Targets by Arbajian, Elsa, Puls, Florian, Antonescu, Cristina R, Amary, Fernanda, Sciot, Raf, Debiec-Rychter, Maria, Sumathi, Vaiyapuri P, Järås, Marcus, Magnusson, Linda, Nilsson, Jenny, Hofvander, Jakob, Mertens, Fredrik

“…Sclerosing epithelioid fibrosarcoma (SEF) is a highly aggressive soft tissue sarcoma closely related to low-grade fibromyxoid sarcoma (LGFMS). Some tumors…”
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Comprehensive genetic analysis identifies a pathognomonic NAB2/STAT6 fusion gene, nonrandom secondary genomic imbalances, and a characteristic gene expression profile in solitary fibrous tumor by Mohajeri, Arezoo, Tayebwa, Johnbosco, Collin, Anna, Nilsson, Jenny, Magnusson, Linda, von Steyern, Fredrik Vult, Brosjö, Otte, Domanski, Henryk A., Larsson, Olle, Sciot, Raf, Debiec-Rychter, Maria, Hornick, Jason L., Mandahl, Nils, Nord, Karolin H., Mertens, Fredrik

“…Solitary fibrous tumor (SFT) is a mesenchymal neoplasm displaying variable morphologic and clinical features. To identify pathogenetically important genetic…”
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Most gene fusions in cancer are stochastic events by Johansson, Bertil, Mertens, Fredrik, Schyman, Tommy, Björk, Jonas, Mandahl, Nils, Mitelman, Felix

“…Cancer‐associated gene fusions resulting in chimeric proteins or aberrant expression of one or both partner genes are pathogenetically and clinically important…”
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“Inflammatory Leiomyosarcoma” and “Histiocyte-rich Rhabdomyoblastic Tumor”: a clinicopathological, immunohistochemical and genetic study of 13 cases, with a proposal for reclassification as “Inflammatory Rhabdomyoblastic Tumor” by Cloutier, Jeffrey M., Charville, Gregory W., Mertens, Fredrik, Sukov, William, Fritchie, Karen, Perry, Kyle D., Edgar, Mark, Rowsey, Ross A., Folpe, Andrew L.

“…Inflammatory leiomyosarcoma (ILMS), defined as “a malignant neoplasm showing smooth muscle differentiation, a prominent inflammatory infiltrate, and…”
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PHF1 fusions cause distinct gene expression and chromatin accessibility profiles in ossifying fibromyxoid tumors and mesenchymal cells by Hofvander, Jakob, Jo, Vickie Y., Fletcher, Christopher D. M., Puls, Florian, Flucke, Uta, Nilsson, Jenny, Magnusson, Linda, Mertens, Fredrik

“…Ossifying fibromyxoid tumor (OFMT) is a soft tissue tumor frequently displaying gene fusions, most of which affect the PHF1 gene. PHF1 encodes plant…”
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HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions by Bruford, Elspeth A., Antonescu, Cristina R., Carroll, Andrew J., Chinnaiyan, Arul, Cree, Ian A., Cross, Nicholas C. P., Dalgleish, Raymond, Gale, Robert Peter, Harrison, Christine J., Hastings, Rosalind J., Huret, Jean-Loup, Johansson, Bertil, Le Beau, Michelle, Mecucci, Cristina, Mertens, Fredrik, Verhaak, Roel, Mitelman, Felix

“…Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no…”
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A novel SERPINE1-FOSB fusion gene results in transcriptional up-regulation of FOSB in pseudomyogenic haemangioendothelioma by Walther, Charles, Tayebwa, Johnbosco, Lilljebjörn, Henrik, Magnusson, Linda, Nilsson, Jenny, von Steyern, Fredrik Vult, Øra, Ingrid, Domanski, Henryk A, Fioretos, Thoas, Nord, Karolin H, Fletcher, Christopher DM, Mertens, Fredrik

“…Pseudomyogenic haemangioendothelioma (PHE) is an intermediate malignant vascular soft tissue tumour primarily affecting children and young adults. The…”
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Tetraploidization Increases the Motility and Invasiveness of Cancer Cells by Jemaà, Mohamed, Daams, Renee, Charfi, Slim, Mertens, Fredrik, Huber, Stephan M, Massoumi, Ramin

“…Polyploidy and metastasis are associated with a low probability of disease-free survival in cancer patients. Polyploid cells are known to facilitate…”
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Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data by Wang, Lu, Motoi, Toru, Khanin, Raya, Olshen, Adam, Mertens, Fredrik, Bridge, Julia, Cin, Paola Dal, Antonescu, Cristina R., Singer, Samuel, Hameed, Meera, Bovee, Judith V.M.G., Hogendoorn, Pancras C. W., Socci, Nicholas, Ladanyi, Marc

“…Cancer gene fusions that encode a chimeric protein are often characterized by an intragenic discontinuity in the RNA\expression levels of the exons that are 5′…”
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FN1-EGF gene fusions are recurrent in calcifying aponeurotic fibroma by Puls, Florian, Hofvander, Jakob, Magnusson, Linda, Nilsson, Jenny, Haywood, Elaine, Sumathi, Vaiyapuri P, Mangham, D Chas, Kindblom, Lars-Gunnar, Mertens, Fredrik

“…Calcifying aponeurotic fibroma (CAF) is a soft tissue neoplasm with a predilection for the hands and feet in children and adolescents. Its molecular basis is…”
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Frequent miRNA-convergent fusion gene events in breast cancer by Persson, Helena, Søkilde, Rolf, Häkkinen, Jari, Pirona, Anna Chiara, Vallon-Christersson, Johan, Kvist, Anders, Mertens, Fredrik, Borg, Åke, Mitelman, Felix, Höglund, Mattias, Rovira, Carlos

“…Studies of fusion genes have mainly focused on the formation of fusions that result in the production of hybrid proteins or, alternatively, on…”
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Primary Pseudomyogenic Hemangioendothelioma of Bone by Inyang, Alero, Mertens, Fredrik, Puls, Florian, Sumathi, Vaiyapuri, Inwards, Carrie, Folpe, Andrew, Lee, Cheng-Han, Zhang, Yaxia, Symmans, Pennie, Rubin, Brian, Nielsen, Gunnlaugur P, Nguyen, Van-Hung, Rosenberg, Andrew E

“…Pseudomyogenic hemangioendothelioma (PMH) is a well-recognized neoplasm that usually arises in the soft tissue; concurrent bone involvement occurs in 24% of…”
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Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years by Hofvander, Jakob, Viklund, Björn, Isaksson, Anders, Brosjö, Otte, Vult von Steyern, Fredrik, Rissler, Pehr, Mandahl, Nils, Mertens, Fredrik

“…To compare clonal evolution in tumors arising through different mechanisms, we selected three types of sarcoma—amplicon-driven well-differentiated liposarcoma…”
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Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas by Joseph, Christine G., Hwang, Heejung, Jiao, Yuchen, Wood, Laura D., Kinde, Isaac, Wu, Jian, Mandahl, Nils, Luo, Jinyong, Hruban, Ralph H., Diaz Jr, Luis A., He, Tong-Chuan, Vogelstein, Bert, Kinzler, Kenneth W., Mertens, Fredrik, Papadopoulos, Nickolas

“…Bone and soft tissue sarcomas are a group of histologically heterogeneous and relatively uncommon tumors. To explore their genetic origins, we sequenced the…”
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Genetic heterogeneity in rhabdomyosarcoma revealed by SNP array analysis by Walther, Charles, Mayrhofer, Markus, Nilsson, Jenny, Hofvander, Jakob, Jonson, Tord, Mandahl, Nils, Øra, Ingrid, Gisselsson, David, Mertens, Fredrik

“…Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and adolescents. Alveolar (ARMS) and embryonal (ERMS) histologies predominate, but…”
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