Search Results - "Merten, Christoph"

Dynein-Based Accumulation of Membranes Regulates Nuclear Expansion in Xenopus laevis Egg Extracts by Hara, Yuki, Merten, Christoph A.

“…Nuclear size changes dynamically during development and has long been observed to correlate with the space surrounding the nucleus, as well as with the volume…”
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Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics by Shembekar, Nachiket, Chaipan, Chawaree, Utharala, Ramesh, Merten, Christoph A

“…Droplet-based microfluidics enables assays to be carried out at very high throughput (up to thousands of samples per second) and enables researchers to work…”
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Design and construction of a microfluidics workstation for high-throughput multi-wavelength fluorescence and transmittance activated droplet analysis and sorting by Panwar, Jatin, Autour, Alexis, Merten, Christoph A.

“…Droplet microfluidics has revolutionized quantitative high-throughput bioassays and screening, especially in the field of single-cell analysis where…”
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Fluorescence-activated droplet sequencing (FAD-seq) directly provides sequences of screening hits in antibody discovery by Autour, Alexis, Merten, Christoph A

“…Droplet microfluidics has become a very powerful tool in high-throughput screening, including antibody discovery. Screens are usually carried out by physically…”
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A microfluidics platform for combinatorial drug screening on cancer biopsies by Eduati, Federica, Utharala, Ramesh, Madhavan, Dharanija, Neumann, Ulf Peter, Longerich, Thomas, Cramer, Thorsten, Saez-Rodriguez, Julio, Merten, Christoph A.

“…Screening drugs on patient biopsies from solid tumours has immense potential, but is challenging due to the small amount of available material. To address…”
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Microfluidics as an Emerging Precision Tool in Developmental Biology by Sonnen, Katharina F., Merten, Christoph A.

“…Microfluidics has become a precision tool in modern biology. It enables omics data to be obtained from individual cells, as compared to averaged signals from…”
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Microfluidics as an Enabling Technology for Personalized Cancer Therapy by Mathur, Lukas, Ballinger, Martine, Utharala, Ramesh, Merten, Christoph A.

“…Tailoring patient‐specific treatments for cancer is necessary in order to achieve optimal results but requires new diagnostic approaches at affordable prices…”
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Single-Cell Droplet Microfluidic Screening for Antibodies Specifically Binding to Target Cells by Shembekar, Nachiket, Hu, Hongxing, Eustace, David, Merten, Christoph A.

“…Monoclonal antibodies are a main player in modern drug discovery. Many antibody screening formats exist, each with specific advantages and limitations…”
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Functional single-cell hybridoma screening using droplet-based microfluidics by Debs, Bachir El, Utharala, Ramesh, Balyasnikova, Irina V, Griffiths, Andrew D, Merten, Christoph A

“…Monoclonal antibodies can specifically bind or even inhibit drug targets and have hence become the fastest growing class of human therapeutics. Although they…”
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Microfluidic single-cell technology in immunology and antibody screening by Seah, Yu Fen Samantha, Hu, Hongxing, Merten, Christoph A.

“…Single-cell technology has a major impact on the field of immunology. It enables the kinetics and logic of immune signaling and immune cell migration to be…”
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Technological and computational advances driving high-throughput oncology by Kolmar, Leonie, Autour, Alexis, Ma, Xiaoli, Vergier, Blandine, Eduati, Federica, Merten, Christoph A

“…Engineering and computational advances have opened many new avenues in cancer research, particularly when being exploited in interdisciplinary approaches. For…”
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Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation by Sonnen, Katharina F., Lauschke, Volker M., Uraji, Julia, Falk, Henning J., Petersen, Yvonne, Funk, Maja C., Beaupeux, Mathias, François, Paul, Merten, Christoph A., Aulehla, Alexander

“…How signaling dynamics encode information is a central question in biology. During vertebrate development, dynamic Notch signaling oscillations control…”
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Patient‐specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies by Eduati, Federica, Jaaks, Patricia, Wappler, Jessica, Cramer, Thorsten, Merten, Christoph A, Garnett, Mathew J, Saez‐Rodriguez, Julio

“…Mechanistic modeling of signaling pathways mediating patient‐specific response to therapy can help to unveil resistance mechanisms and improve therapeutic…”
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Efficient cell pairing in droplets using dual-color sorting by Hu, Hongxing, Eustace, David, Merten, Christoph A

“…The use of microfluidic droplets has become a powerful tool for the screening and manipulation of cells. However, currently this is restricted to assays…”
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Differential contribution of nuclear size scaling mechanisms between Xenopus species by Heijo, Hiroko, Merten, Christoph A., Hara, Yuki

“…Size of the nucleus, a membrane‐bound organelle for DNA replication and transcription in eukaryotic cells, varies to adapt nuclear functions to the surrounding…”
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A Versatile, Low-Cost, Multiway Microfluidic Sorter for Droplets, Cells, and Embryos by Utharala, Ramesh, Tseng, Qingzong, Furlong, Eileen E. M, Merten, Christoph A

“…Partitioning and sorting particles, including molecules, cells and organisms, is an essential prerequisite for a diverse range of applications. Here, we…”
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Imaging of mRNA in Live Cells Using Nucleic Acid-Templated Reduction of Azidorhodamine Probes by Pianowski, Zbigniew, Gorska, Katarzyna, Oswald, Laurence, Merten, Christoph A, Winssinger, Nicolas

“…Nucleic acid-templated reactions leading to a fluorescent product represent an attractive strategy for the detection and imaging of cellular nucleic acids…”
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Screening for drivers of SARS-CoV-2 uptake by Autour, Alexis, Merten, Christoph A.

“…Genetic and cellular drivers of the cellular uptake of SARS-CoV-2 can be screened at high throughput via droplet microfluidics and size-exclusion methods for…”
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Single-Virus Droplet Microfluidics for High-Throughput Screening of Neutralizing Epitopes on HIV Particles by Chaipan, Chawaree, Pryszlak, Anna, Dean, Hansi, Poignard, Pascal, Benes, Vladimir, Griffiths, Andrew D, Merten, Christoph A

“…Analyzing surface epitopes of single HIV particles holds great potential for the development of vaccine candidates. However, existing technologies do not allow…”
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A microfluidic Braille valve platform for on-demand production, combinatorial screening and sorting of chemically distinct droplets by Utharala, Ramesh, Grab, Anna, Vafaizadeh, Vida, Peschke, Nicolas, Ballinger, Martine, Turei, Denes, Tuechler, Nadine, Ma, Wenwei, Ivanova, Olga, Ortiz, Alejandro Gil, Saez-Rodriguez, Julio, Merten, Christoph A.

“…Droplet microfluidics is a powerful tool for a variety of biological applications including single-cell genetics, antibody discovery and directed evolution…”
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