Is abnormal glucose metabolism during pregnancy related to endothelial dysfunction?

Abstract Objective: Endothelial dysfunction is an independent risk factor for cardiovascular events. We aimed to investigate the relationship between endothelial dysfunction and gestational diabetes mellitus and impaired glucose tolerance. Methods: Pregnant women who had impaired glucose metabolism...

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Published in:	The journal of maternal-fetal & neonatal medicine Vol. 28; no. 2; pp. 182 - 185
Main Authors:	Gungor, Omer, Gazi, Emine, Ozkececi, Gulay, Cakir Gungor, Ayse Nur, Cevizci, Sibel, Hacivelioglu, Servet, Temiz, Ahmet, Mert, Nadire, Koken, Gulengul
Format:	Journal Article
Language:	English
Published:	England Informa UK Ltd 01-01-2015 Informa Healthcare
Subjects:	Adult Blood Glucose - metabolism Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - metabolism Cardiovascular Diseases - physiopathology Case-Control Studies Diabetes, Gestational - epidemiology Diabetes, Gestational - metabolism Diabetes, Gestational - physiopathology Endothelial dysfunction Endothelium, Vascular - physiopathology Female gestational diabetes Glucose Intolerance - complications Glucose Intolerance - epidemiology Glucose Intolerance - metabolism Glucose Intolerance - physiopathology Glucose Tolerance Test Humans Pregnancy Pregnancy Complications, Cardiovascular - epidemiology Pregnancy Complications, Cardiovascular - etiology Risk Factors Young Adult Endothelial dysfunction gestational diabetes pregnancy
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Summary:	Abstract Objective: Endothelial dysfunction is an independent risk factor for cardiovascular events. We aimed to investigate the relationship between endothelial dysfunction and gestational diabetes mellitus and impaired glucose tolerance. Methods: Pregnant women who had impaired glucose metabolism in the 75-g oral glucose tolerance test (OGTT) and their age- and body mass index-matched controls were included in the study and assessed for flow-mediated vasodilatation to evaluate endothelial dysfunction. Results: A total of 51 patients participated in the study. There were 20 patients in the control group, 13 in the impaired glucose tolerance group and 18 in the gestational diabetes mellitus group. Flow-mediated vasodilatation measured at the 60th and 120th seconds were significantly lower in the impaired glucose tolerance and gestational diabetes mellitus groups than in the control group (8.5 ± 5.7 and 8.9 ± 6.5 versus 14.9 ± 9.0, p = 0.022 and 6.2 ± 6.7 and 5.2 ± 5.0 versus 12.0 ± 8.3, p = 0.011, respectively). Conclusions: Patients with gestational diabetes mellitus and impaired glucose tolerance have impaired endothelial dysfunction. Delivery might have protective effects on endothelial functions. The significance of impaired endothelial dysfunction for pregnant women must be investigated, and if needed, lifestyle changes might be suggested, according to the determined importance of the endothelial dysfunction.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1476-7058 1476-4954
DOI:	10.3109/14767058.2014.906574