UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area

The Small Molecule Discovery Center (SMDC) at the University of California, San Francisco, works collaboratively with the scientific community to solve challenging problems in chemical biology and drug discovery. The SMDC includes a high throughput screening facility, medicinal chemistry, and resear...

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Bibliographic Details
Published in:	Combinatorial chemistry & high throughput screening Vol. 17; no. 4; p. 333
Main Authors:	Arkin, Michelle R, Ang, Kenny K H, Chen, Steven, Davies, Julia, Merron, Connie, Tang, Yinyan, Wilson, Christopher G M, Renslo, Adam R
Format:	Journal Article
Language:	English
Published:	United Arab Emirates 01-05-2014
Subjects:	Academies and Institutes - organization & administration Antiparasitic Agents - pharmacology California Chemistry, Pharmaceutical - methods Cooperative Behavior Drug Delivery Systems Drug Discovery - organization & administration Drug Evaluation, Preclinical - methods High-Throughput Screening Assays - methods Humans Internet Molecular Targeted Therapy Neglected Diseases - drug therapy Potassium Channels, Tandem Pore Domain Private Sector Small Molecule Libraries Translational Medical Research - organization & administration Universities - organization & administration California
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Summary:	The Small Molecule Discovery Center (SMDC) at the University of California, San Francisco, works collaboratively with the scientific community to solve challenging problems in chemical biology and drug discovery. The SMDC includes a high throughput screening facility, medicinal chemistry, and research labs focused on fundamental problems in biochemistry and targeted drug delivery. Here, we outline our HTS program and provide examples of chemical tools developed through SMDC collaborations. We have an active research program in developing quantitative cell-based screens for primary cells and whole organisms; here, we describe whole-organism screens to find drugs against parasites that cause neglected tropical diseases. We are also very interested in target-based approaches for so-called "undruggable", protein classes and fragment-based lead discovery. This expertise has led to several pharmaceutical collaborations; additionally, the SMDC works with start-up companies to enable their early-stage research. The SMDC, located in the biotech-focused Mission Bay neighborhood in San Francisco, is a hub for innovative small-molecule discovery research at UCSF.
ISSN:	1875-5402
DOI:	10.2174/1386207317666140323133841