Search Results - "Merriman, K"

High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble by Ganser, Laura R., Lee, Janghyun, Rangadurai, Atul, Merriman, Dawn K., Kelly, Megan L., Kansal, Aman D., Sathyamoorthy, Bharathwaj, Al-Hashimi, Hashim M.

“…Dynamic ensembles hold great promise in advancing RNA-targeted drug discovery. Here we subjected the transactivation response element (TAR) RNA from human…”
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iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications by Ou, Jingxing, Ball, John M., Luan, Yizhao, Zhao, Tantai, Miyagishima, Kiyoharu J., Xu, Yufeng, Zhou, Huizhi, Chen, Jinguo, Merriman, Dana K., Xie, Zhi, Mallon, Barbara S., Li, Wei

“…Hibernating mammals survive hypothermia (<10°C) without injury, a remarkable feat of cellular preservation that bears significance for potential medical…”
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Inhibition of Borna disease virus replication by an endogenous bornavirus-like element in the ground squirrel genome by Fujino, Kan, Horie, Masayuki, Honda, Tomoyuki, Merriman, Dana K., Tomonaga, Keizo

“…Significance Sequences derived from ancient viruses have been shown to make up a substantial part of animal genomes. Bornaviruses, a genus of nonsegmented,…”
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Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels by Laursen, Willem J., Schneider, Eve R., Merriman, Dana K., Bagriantsev, Sviatoslav N., Gracheva, Elena O.

“…The ability to sense heat is crucial for survival. Increased heat tolerance may prove beneficial by conferring the ability to inhabit otherwise prohibitive…”
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Diurnal rodents as pertinent animal models of human retinal physiology and pathology by Verra, Daniela M., Sajdak, Benjamin S., Merriman, Dana K., Hicks, David

“…This presentation will survey the retinal architecture, advantages, and limitations of several lesser-known rodent species that provide a useful diurnal…”
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The Effects of CEO Pay Structure on Corporate Social Performance by Deckop, John R., Merriman, Kimberly K., Gupta, Shruti

“…Corporate social performance (CSP) is increasingly viewed as an important business outcome by researchers, investors, and society as a whole. Furthermore,…”
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Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters by Matos-Cruz, Vanessa, Schneider, Eve R., Mastrotto, Marco, Merriman, Dana K., Bagriantsev, Sviatoslav N., Gracheva, Elena O.

“…Thirteen-lined ground squirrels and Syrian hamsters are known for their ability to withstand cold during hibernation. We found that hibernators exhibit cold…”
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Differential composition of DHA and very-long-chain PUFAs in rod and cone photoreceptors by Agbaga, Martin-Paul, Merriman, Dana K., Brush, Richard S., Lydic, Todd A., Conley, Shannon M., Naash, Muna I., Jackson, Shelley, Woods, Amina S., Reid, Gavin E., Busik, Julia V., Anderson, Robert E.

“…Long-chain PUFAs (LC-PUFAs; C20–C22; e.g., DHA and arachidonic acid) are highly enriched in vertebrate retina, where they are elongated to very-long-chain…”
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Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation by Mohr, Sarah M., Dai Pra, Rafael, Platt, Maryann P., Feketa, Viktor V., Shanabrough, Marya, Varela, Luis, Kristant, Ashley, Cao, Haoran, Merriman, Dana K., Horvath, Tamas L., Bagriantsev, Sviatoslav N., Gracheva, Elena O.

“…Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal physiological functions, but the mechanisms…”
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Osmolyte Depletion and Thirst Suppression Allow Hibernators to Survive for Months without Water by Feng, Ni Y., Junkins, Madeleine S., Merriman, Dana K., Bagriantsev, Sviatoslav N., Gracheva, Elena O.

“…Thirteen-lined ground squirrels (Ictidomys tridecemlineatus) are obligatory hibernators who can survive over 6 months of the year in underground burrows or…”
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A rare case of erythema annulare centrifugum resolving with narrowband ultraviolet B phototherapy by Caesar, J. G., James, S., Merriman, K., Peat, L., Hayes, M., Powell, J. B.

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The association of diabetes and anti-diabetic medications with clinical outcomes in multiple myeloma by Wu, W, Merriman, K, Nabaah, A, Seval, N, Seval, D, Lin, H, Wang, M, Qazilbash, M H, Baladandayuthapani, V, Berry, D, Orlowski, R Z, Lee, M-H, Yeung, S-C J

“…Background: Insulin/insulin-like growth factor-1 signalling may underlie the promoting effect of type 2 diabetes on cancer. This study examined the association…”
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CNGA3 acts as a cold sensor in hypothalamic neurons by Feketa, Viktor V, Nikolaev, Yury A, Merriman, Dana K, Bagriantsev, Sviatoslav N, Gracheva, Elena O

“…Most mammals maintain their body temperature around 37°C, whereas in hibernators it can approach 0°C without triggering a thermogenic response. The remarkable…”
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Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation by Laursen, Willem J., Mastrotto, Marco, Pesta, Dominik, Funk, Owen H., Goodman, Jena B., Merriman, Dana K., Ingolia, Nicholas, Shulman, Gerald I., Bagriantsev, Sviatoslav N., Gracheva, Elena O.

“…Significance Mammalian hibernators can reduce their metabolic rate by 95% and body temperature to 2 °C. However, their central and peripheral nervous systems…”
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Comparison of Seasonal foEs and fbEs Occurrence Rates Derived from Global Digisonde Measurements by Merriman, Dawn K., Nava, Omar A., Dao, Eugene V., Emmons, Daniel J.

“…A global climatology of sporadic-E occurrence rates (ORs) based on ionosonde measurements is presented for the peak blanketing frequency, fbEs, and the…”
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Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization by Xu, Ran, Andres-Mateos, Eva, Mejias, Rebeca, MacDonald, Elizabeth M., Leinwand, Leslie A., Merriman, Dana K., Fink, Rainer H.A., Cohn, Ronald D.

“…Skeletal muscle atrophy is a very common clinical challenge in many disuse conditions. Maintenance of muscle mass is crucial to combat debilitating functional…”
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Microvesicle release from inner segments of healthy photoreceptors is a conserved phenomenon in mammalian species by Lewis, Tylor R, Phan, Sebastien, Kim, Keun-Young, Jha, Isha, Castillo, Carson M, Ding, Jin-Dong, Sajdak, Benjamin S, Merriman, Dana K, Ellisman, Mark H, Arshavsky, Vadim Y

“…Many inherited visual diseases arise from mutations that affect the structure and function of photoreceptor cells. In some cases, the pathology is accompanied…”
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Pseudouridine and N6-methyladenosine modifications weaken PUF protein/RNA interactions by Vaidyanathan, Pavanapuresan P, AlSadhan, Ishraq, Merriman, Dawn K, Al-Hashimi, Hashim M, Herschlag, Daniel

“…RNA modifications are ubiquitous in biology, with over 100 distinct modifications. While the vast majority were identified and characterized on abundant…”
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Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels by Andres-Mateos, Eva, Mejias, Rebeca, Soleimani, Arshia, Lin, Brian M, Burks, Tyesha N, Marx, Ruth, Lin, Benjamin, Zellars, Richard C, Zhang, Yonggang, Huso, David L, Marr, Tom G, Leinwand, Leslie A, Merriman, Dana K, Cohn, Ronald D

“…Skeletal muscle atrophy can occur as a consequence of immobilization and/or starvation in the majority of vertebrates studied. In contrast, hibernating mammals…”
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A potentially abundant junctional RNA motif stabilized by m6A and Mg2 by Liu, Bei, Merriman, Dawn K., Choi, Seung H., Schumacher, Maria A., Plangger, Raphael, Kreutz, Christoph, Horner, Stacy M., Meyer, Kate D., Al-Hashimi, Hashim M.

“…N 6 -Methyladenosine (m 6 A) is an abundant post-transcriptional RNA modification that influences multiple aspects of gene expression. In addition to…”
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