Search Results - "Merriel, Samuel W D"

Systematic review and meta-analysis of the diagnostic accuracy of prostate-specific antigen (PSA) for the detection of prostate cancer in symptomatic patients by Merriel, Samuel W D, Pocock, Lucy, Gilbert, Emma, Creavin, Sam, Walter, Fiona M, Spencer, Anne, Hamilton, Willie

“…Prostate-specific antigen (PSA) is a commonly used test to detect prostate cancer. Attention has mostly focused on the use of PSA in screening asymptomatic…”
Get full text

Association between patient ethnicity and prostate cancer diagnosis following a prostate-specific antigen test: a cohort study of 730,000 men in primary care in the UK by Down, Liz, Barlow, Melissa, Bailey, Sarah E R, Mounce, Luke T A, Merriel, Samuel W D, Watson, Jessica, Martins, Tanimola

“…Black men have higher prostate-specific antigen (PSA) levels and higher prostate cancer incidence and mortality than White men, while Asian men tend to have…”
Get full text

Clinical trials in cancer screening, prevention and early diagnosis (SPED): a systematic mapping review by O'Dowd, Emma L, Merriel, Samuel W. D, Cheng, Vinton W. T, Khan, Sam, Howells, Lynne M, Gopal, Dipesh P, Roundhill, Elizabeth A, Brennan, Paul M, Crosbie, Philip A. J, Neal, Richard D, Brown, Karen, Crosbie, Emma J, Baldwin, David R

“…Abstract Background Global annual cancer incidence is forecast to rise to 27.5 M by 2040, a 62% increase from 2018. For most cancers, prevention and early…”
Get full text

The diagnostic performance of CA-125 for the detection of ovarian cancer in women from different ethnic groups: a cohort study of English primary care data by Barlow, Melissa, Down, Liz, Mounce, Luke T A, Funston, Garth, Merriel, Samuel W D, Watson, Jessica, Abel, Gary, Kirkland, Lucy, Martins, Tanimola, Bailey, Sarah E R

“…CA-125 testing is a recommended first line investigation for women presenting with possible symptoms of ovarian cancer in English primary care, to help…”
Get full text

A modified Delphi study to develop a practical guide for selecting patients with prostate cancer for active surveillance by Merriel, Samuel W D, Moon, Daniel, Dundee, Phil, Corcoran, Niall, Carroll, Peter, Partin, Alan, Smith, Joseph A, Hamdy, Freddie, Moore, Caroline, Ost, Piet, Costello, Tony

“…Active surveillance (AS) is a management option for men diagnosed with lower risk prostate cancer. There is wide variation in all aspects of AS…”
Get full text

Applying a genetic risk score for prostate cancer to men with lower urinary tract symptoms in primary care to predict prostate cancer diagnosis: a cohort study in the UK Biobank by Green, Harry D., Merriel, Samuel W. D., Oram, Richard A., Ruth, Katherine S., Tyrrell, Jessica, Jones, Samuel E., Thirlwell, Chrissie, Weedon, Michael N., Bailey, Sarah E. R.

“…Background Prostate cancer is highly heritable, with >250 common variants associated in genome-wide association studies. It commonly presents with non-specific…”
Get full text

Why test study protocol: a UK-wide audit using the primary care academic collaborative to explore the reasons for primary care testing by Burrell, Alexander, Duncan, Polly, Bennett-Britton, Ian, Hodgson, Sam, Merriel, Samuel W D, Waqar, Salman, Whiting, Penny, Watson, Jessica

“…The number of blood tests done in primary care has been increasing over the last 20 years. Some estimates suggest that up to a quarter of these tests may not…”
Get full text

Colorectal cancer risk stratification using a polygenic risk score in symptomatic primary care patients-a UK Biobank retrospective cohort study by Mallabar-Rimmer, Bethan, Merriel, Samuel W D, Webster, Amy P, Jackson, Leigh, Wood, Andrew R, Barclay, Matthew, Tyrrell, Jessica, Ruth, Katherine S, Thirlwell, Christina, Oram, Richard, Weedon, Michael N, Bailey, Sarah E R, Green, Harry D

“…Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide. Accurate cancer risk assessment approaches could increase rates of early CRC…”
Get full text

Response to: Genetic risk scores may compound rather than solve the issue of prostate cancer overdiagnosis (BJC-LT3342090) by Green, Harry D., Merriel, Samuel W. D., Oram, Richard A., Ruth, Katherine S., Tyrrell, Jessica, Jones, Samuel E., Thirlwell, Chrissie, Weedon, Michael N., Bailey, Sarah E. R.

Get full text

Comparison of Multiparametric Magnetic Resonance Imaging and Targeted Biopsy With Systematic Biopsy Alone for the Diagnosis of Prostate Cancer: A Systematic Review and Meta-analysis by Elwenspoek, Martha M C, Sheppard, Athena L, McInnes, Matthew D F, Merriel, Samuel W D, Rowe, Edward W J, Bryant, Richard J, Donovan, Jenny L, Whiting, Penny

“…The current diagnostic pathway for patients with suspected prostate cancer (PCa) includes prostate biopsy. A large proportion of individuals who undergo biopsy…”
Get full text

Best practice in active surveillance for men with prostate cancer: a Prostate Cancer UK consensus statement by Merriel, Samuel W.D., Hetherington, Liz, Seggie, Andrew, Castle, Joanna T., Cross, William, Roobol, Monique J., Gnanapragasam, Vincent, Moore, Caroline M., Ashworth, Mark, Bradley, E, Cass, Keith, Cornford, Philip, Keanie, Julian, Little, Scott, Mastris, Ken, Nairn, Adam, Oxley, Jon, Parker, Chris, Patel, Amit, Porter, Robin, Powell, Lucy, Richenberg, Jonathan, Roland, Martin, Varma, Murali, Victor, Deborah, Waymont, Clare

“…Objectives To develop a consensus statement on current best practice of active surveillance (AS) in the UK, informed by patients and clinical experts. Subjects…”
Get full text

Exploring the Causes of Death Among Patients With Metastatic Prostate Cancer-A Changing Landscape by Merriel, Samuel W D, Martins, Tanimola, Bailey, Sarah E R

Get full text

Prostate Cancer in Primary Care by Merriel, Samuel W. D., Funston, Garth, Hamilton, Willie

“…Prostate cancer is a common malignancy seen worldwide. The incidence has risen in recent decades, mainly fuelled by more widespread use of prostate-specific…”
Get full text

Direct access to imaging for cancer from primary care by Merriel, Samuel W D, Francetic, Igor, Buttle, Peter

Get more information

Community diagnostic centres: bringing diagnostics closer to home by Merriel, Samuel Wd, Lee, Lennard, Neal, Richard

“…Merriel et al discuss community diagnostic centres in the UK which is bringing diagnostics closer to home. In October 2021, NHS England announced the creation…”
Get full text

Association between unexplained hypoalbuminaemia and new cancer diagnoses in UK primary care patients by Merriel, Samuel W D, Carroll, Robert, Hamilton, Fergus, Hamilton, William

“…The association between hypoalbuminaemia and a new diagnosis of cancer is as yet unknown. This study aimed to assess whether unexplained hypoalbuminaemia was…”
Get full text

Determining the role of genetic risk scores in symptomatic cancer detection by Bailey, Sarah Er, Butler, Celia Am, Katsampouris, Evangelos, Kessler, Larry, Quaife, Samantha L, Saya, Sibel, Merriel, Samuel Wd

“…Improving cancer diagnosis is a national priority in the UK. with the NHS Long Term Plan pledging to increase the percentage of cancers found at an early stage…”
Get full text

Patient-Centered Outcomes From Multiparametric MRI and MRI-Guided Biopsy for Prostate Cancer: A Systematic Review by Merriel, Samuel W.D., Hardy, Victoria, Thompson, Matthew J., Walter, Fiona M., Hamilton, Willie

“…To identify and characterize patient-centered outcomes (PCOs) relating to multiparametric MRI (mpMRI) and MRI-guided biopsy as diagnostic tests for possible…”
Get full text

Implementation of a modified obstetric early warning system to improve the quality of obstetric care in Zimbabwe by Merriel, Abi, Murove, Bobb T., Merriel, Samuel W.D., Sibanda, Thabani, Moyo, Sikangezile, Crofts, Joanna

“…Objective To implement a modified obstetric early warning system (MOEWS) to promote identification and stabilization of unwell women. Methods A…”
Get full text

Systematic Review and Narrative Synthesis of Economic Evaluations of Prostate Cancer Diagnostic Pathways Incorporating Prebiopsy Magnetic Resonance Imaging by Merriel, Samuel W.D., Hall, Rebekah, Walter, Fiona M., Hamilton, Willie, Spencer, Anne E.

“…Integration of prebiopsy magnetic resonance imaging (MRI) into prostate cancer diagnostic pathways is likely to be more cost effective than traditional…”
Get full text