Search Results - "Merricks, E"

Procoagulant Microparticles in Dogs with Immune‐Mediated Hemolytic Anemia by Kidd, L., Geddings, J., Hisada, Y., Sueda, M., Concannon, T., Nichols, T., Merricks, E., Mackman, N.

“…Background Studies of some human prothrombotic diseases suggest that phosphatidylserine‐positive (PS+) and tissue factor‐positive (TF+) microparticles (MPs)…”
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Improved kinetics of rIX‐FP, a recombinant fusion protein linking factor IX with albumin, in cynomolgus monkeys and hemophilia B dogs by NOLTE, M. W., NICHOLS, T. C., MUELLER‐COHRS, J., MERRICKS, E. P., PRAGST, I., ZOLLNER, S., DICKNEITE, G.

“…Background:  Prophylaxis of hemophilia B, at present, requires multiple infusions of human factor (F)IX concentrates per week. A FIX molecule with a prolonged…”
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An anti-αVβ3 antibody inhibits coronary artery atherosclerosis in diabetic pigs by Maile, L.A, Busby, W.H, Xi, G, Gollahan, K.P, Flowers, W, Gafbacik, N, Gafbacik, S, Stewart, K, Merricks, E.P, Nichols, T.C, Bellinger, D.A, Clemmons, D.R

“…Abstract Background and aims Diabetes is a major risk factor for the development of atherosclerosis. Hyperglycemia stimulates vascular smooth muscle cells (…”
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Pharmacokinetics and pharmacodynamics of turoctocog alfa and N8-GP in haemophilia A dogs by Agersø, H., Stennicke, H. R., Pelzer, H., Olsen, E. N., Merricks, E. P., deFriess, N. A., Nichols, T. C., Ezban, M.

“…Summary The objective of the present study was to evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of the new recombinant FVIII compound…”
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Protease-Resistant Insulin-Like Growth Factor (IGF)-Binding Protein-4 Inhibits IGF-I Actions and Neointimal Expansion in a Porcine Model of Neointimal Hyperplasia by Nichols, T. C, Busby, W. H, Merricks, E, Sipos, J, Rowland, M, Sitko, K, Clemmons, D. R

“…IGF-I has been shown to play a role in the progression of atherosclerosis in experimental animal models. IGF-binding protein-4 (IGFBP-4) binds to IGF-I and…”
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Sensitivity of whole blood clotting time and activated partial thromboplastin time for factor IX: relevance to gene therapy and determination of post‐transfusion elimination time of canine factor IX in hemophilia B dogs by NICHOLS, T. C., FRANCK, H. W. G., FRANCK, C. T., de FRIESS, N., RAYMER, R. A., MERRICKS, E. P.

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Pharmacokinetics and ex vivo whole blood clot formation of a new recombinant FVIII (N8) in haemophilia A dogs by KARPF, D. M., KJALKE, M., THIM, L., AGERSØ, H., MERRICKS, E. P., DEFRIESS, N., NICHOLS, T. C., EZBAN, M.

“…N8, a new recombinant factor VIII (rFVIII) compound developed for the treatment of haemophilia A, is produced in Chinese hamster ovary (CHO) cells and…”
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Porphyromonas gingivalis Bacteremia Induces Coronary and Aortic Atherosclerosis in Normocholesterolemic and Hypercholesterolemic Pigs by Brodala, Nadine, Merricks, Elizabeth P, Bellinger, Dwight A, Damrongsri, Damrong, Offenbacher, Steven, Beck, James, Madianos, Phoebus, Sotres, Daniela, Chang, Yu-Ling, Koch, Gary, Nichols, Timothy C

“…OBJECTIVES—The aim of this study was to determine whether recurrent intravenous injections with Porphyromonas gingivalis (P gingivalis), mimicking…”
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A phase II prospective open-label escalating dose trial of recombinant interleukin-11 in mild von Willebrand disease by RAGNI, M. V., JANKOWITZ, R. C., CHAPMAN, H. L., MERRICKS, E. P., KLOOS, M. T., DILLOW, A. M., NICHOLS, T. C.

“…von Willebrand factor (VWF) is a multimeric glycoprotein that mediates platelet adhesion and is decreased in von Willebrand disease (VWD). 1‐8…”
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Prevention of spontaneous bleeding in dogs with haemophilia A and haemophilia B by NICHOLS, T. C., RAYMER, R. A., FRANCK, H. W. G., MERRICKS, E. P., BELLINGER, D. A., DeFRIESS, N., MARGARITIS, P., ARRUDA, V. R., KAY, M. A., HIGH, K. A.

“…Dogs with haemophilia A or haemophilia B exhibit spontaneous bleeding comparable with the spontaneous bleeding phenotype that occurs in humans with severe…”
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Protein Replacement Therapy and Gene Transfer in Canine Models of Hemophilia A, Hemophilia B, von Willebrand Disease, and Factor VII Deficiency by Nichols, Timothy C, Dillow, Aaron M, Franck, Helen W.G, Merricks, Elizabeth P, Raymer, Robin A, Bellinger, Dwight A, Arruda, Valder R, High, Katherine A

“…Dogs with hemophilia A, hemophilia B, von Willebrand disease (VWD), and factor VII deficiency faithfully recapitulate the severe bleeding phenotype that occurs…”
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Swine models of type 2 diabetes mellitus: Insulin resistance, glucose tolerance, and cardiovascular complications by Bellinger, D.A, Merricks, E.P, Nichols, T.C

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Liver-directed lentiviral gene therapy in a dog model of hemophilia B by Cantore, Alessio, Ranzani, Marco, Bartholomae, Cynthia C, Volpin, Monica, Valle, Patrizia Della, Sanvito, Francesca, Sergi, Lucia Sergi, Gallina, Pierangela, Benedicenti, Fabrizio, Bellinger, Dwight, Raymer, Robin, Merricks, Elizabeth, Bellintani, Francesca, Martin, Samia, Doglioni, Claudio, D'Angelo, Armando, VandenDriessche, Thierry, Chuah, Marinee K, Schmidt, Manfred, Nichols, Timothy, Montini, Eugenio, Naldini, Luigi

“…We investigated the efficacy of liver-directed gene therapy using lentiviral vectors in a large animal model of hemophilia B and evaluated the risk of…”
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Nuclear Factor–κB Activation in Endothelium by Chlamydia pneumoniae without Active Infection by Baer, Jefferson T., du Laney, Tracey V., Wyrick, Priscilla B., McCain, Arlene S., Fischer, Thomas A., Merricks, Elizabeth P., Baldwin, Albert S., Nichols, Timothy C.

“…Causative molecular mechanisms accounting for the potential link between Chlamydia pneumoniae and atherosclerosis are unknown. Formalin and heat-inactivated C…”
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Chemotactic peptide-induced changes of intermediate filament organization in neutrophils during granule secretion: role of cyclic guanosine monophosphate by Pryzwansky, K B, Merricks, E P

“…In neutrophils activated to secrete with formyl-methionyl-leucyl-phenylalanine, intermediate filaments are phosphorylated transiently by cyclic guanosine…”
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Intracellular function in rehydrated lyophilized platelets by FISCHER, Thomas H, MERRICKS, Elizabeth P, RUSSELL, Karen E, RAYMER, Robin A, WHITE, Gilbert C, BODE, Arthur P, NICHOLS, Timothy C, READ, Marjorie S

“…This study aimed to evaluate the effect of cross-linking and lyophilization on intracellular signalling processes in rehydrated, lyophilized (RL) platelets,…”
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Proteasome inhibition ablates activation of NF-kappa B in myocardial reperfusion and reduces reperfusion injury by Pye, Joseph, Ardeshirpour, Farhad, McCain, Arlene, Bellinger, Dwight A, Merricks, Elizabeth, Adams, Julian, Elliott, Peter J, Pien, Christine, Fischer, Thomas H, Baldwin, Jr, Albert S, Nichols, Timothy C

“…Both acute coronary occlusion and reperfusion of an infarct-related artery lead to significant myocardial cell death. Recent evidence has been presented that…”
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Sustained phenotypic correction of canine hemophilia B after systemic administration of helper-dependent adenoviral vector by Brunetti-Pierri, Nicola, Nichols, Timothy C, McCorquodale, Stephanie, Merricks, Elizabeth, Palmer, Donna J, Beaudet, Arthur L, Ng, Philip

“…We have evaluated the potential of liver-directed, helper-dependent adenoviral (HDAd) vector-mediated gene therapy in the hemophilia B dog. Two dogs were…”
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RECOMBINANT IL-11 INCREASES VWF AND VWFMRNA IN TYPE 1 VWD by Jankowitz, R.C., Chapman, H., Merricks, E., Kloos, M., Dillow, A., Nichols, T.C., Ragni, M.V.

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Phase II prospective open-label trial of recombinant interleukin-11 in desmopressin-unresponsive von Willebrand disease and mild or moderate haemophilia A by Ragni, Margaret V, Novelli, Enrico M, Murshed, Anila, Merricks, Elizabeth P, Kloos, Mark T, Nichols, Timothy C

“…Desmopressin (DDAVP) is the treatment of choice in those with mild von Willebrand disease (VWD), yet 20% are unresponsive to DDAVP, and among the 80% who…”
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