Search Results - "Merrick, D T"

Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer by Linger, R M A, Cohen, R A, Cummings, C T, Sather, S, Migdall-Wilson, J, Middleton, D H G, Lu, X, Barón, A E, Franklin, W A, Merrick, D T, Jedlicka, P, DeRyckere, D, Heasley, L E, Graham, D K

“…Non-small cell lung cancer (NSCLC) is a prevalent and devastating disease that claims more lives than breast, prostate, colon and pancreatic cancers combined…”
Get full text

Lung cancer: Premalignant biology and medical prevention by Keith, R.L., Miller, Y.E., Ghosh, M., Franklin, Wilbur A., Nakachi, I., Merrick, D.T.

“…Lung cancer (both adenocarcinoma and squamous cell) progress through a series of pre-malignant histologic changes before the development of invasive disease…”
Get full text

Role of biomarkers for early detection of lung cancer and chemoprevention by Hirsch, F.R, Merrick, D.T, Franklin, W.A

“…Lung cancer is the leading cause of cancer deaths in developed countries. The poor prognosis associated with this disease is closely related to the fact that…”
Get full text

Prostacyclin reverses the cigarette smoke-induced decrease in pulmonary Frizzled 9 expression through miR-31 by Tennis, M. A., New, M. L., McArthur, D. G., Merrick, D. T., Dwyer-Nield, L. D., Keith, R. L.

“…Half of lung cancers are diagnosed in former smokers, leading to a significant treatment burden in this population. Chemoprevention in former smokers using the…”
Get full text

Altered expression of proliferation and differentiation markers in human papillomavirus 16 and 18 immortalized epithelial cells grown in organotypic culture [published erratum appears in Am J Pathol 1992 Mar;140(3):following Table of Contents] by Merrick, DT, Blanton, RA, Gown, AM, McDougall, JK

“…The patterns of expression of keratins K1 and K8, filaggrin, and the proliferation-associated protein, proliferating cell nuclear antigen (PCNA), were studied…”
Get full text

Epithelial cells immortalized by human papillomaviruses have premalignant characteristics in organotypic culture by Blanton, RA, Perez-Reyes, N, Merrick, DT, McDougall, JK

“…Three HPV-16--and four HPV-18--immortalized human foreskin keratinocyte cell lines were analyzed on organotypic epidermal raft cultures at various passage…”
Get full text

Congenital duplication of the tricuspid valve presenting as a circumscribed obstructive mass in the right ventricular outflow tract by Bisognano, J D, Merrick, D T, Popylisen, S L, Hoffman, M S, Weinberger, H D

“…Congenital duplication of the tricuspid valve is a rare condition. We present a case of a 32-year-old man with an increase in intensity of a long-standing…”
Get more information

D18 WHO DOES WHAT IN COPD: THE CELLULAR ORIGINS: Airway Progenitor Exhaustion In Smokers With And Without Chronic Obstructive Pulmonary Disease by Ghosh, M, Miller, Y E, Nakachi, I, Kwon, J B, Brantley, A E, Merrick, D T, Franklin, W A, Keith, R L, Vandivier, R W

“…Airway progenitors were evaluated for numbers, self-renewal, multipotentiality (i.e. the ability to differentiate into a normal respiratory epithelium), and…”
Get full text

Human papillomavirus-immortalized keratinocytes are resistant to the effects of retinoic acid on terminal differentiation by MERRICK, D. T, GOWN, A. M, HALBERT, C. L, BLANTON, R. A, MCDOUGALL, J. K

“…In order to study how human papillomaviruses (HPVs) can alter normal epithelial cell differentiation, we looked at the response to retinoic acid (RA) of…”
Get full text

Re-expression of interleukin 1 in human papillomavirus 18 immortalized keratinocytes inhibits their tumorigenicity in nude mice by MERRICK, D. T, WINBERG, G, MCDOUGALL, J. K

“…The ability to form tumors in nude mice developed spontaneously in the human papillomavirus (HPV)-18 immortalized keratinocyte cell line, 18-11, and is shown…”
Get full text

Quantitative assessment of PD-L1 as an analyte in immunohistochemistry diagnostic assays using a standardized cell line tissue microarray by Martinez-Morilla, Sandra, McGuire, John, Gaule, Patricia, Moore, Lauren, Acs, Balazs, Cougot, Delphine, Gown, Allen M., Yaziji, Hadi, Wang, Wei-Lien, Cartun, Richard W., Hornick, Jason L., Sholl, Lynette M., Qiu, Jingxin, Mino-Kenudson, Mari, Yi, Eunhee S., Beasley, Mary Beth, Merrick, Daniel T., Ambaye, Abiy B., Zhang, Zhong J., Walker, Jill, Rimm, David L.

“…Programmed death 1 ligand 1 (PD-L1) Immunohistochemistry (IHC) is the key FDA-approved predictive marker to identify responders to anti-PD1 axis drugs…”
Get full text

Insulin-like growth factor receptor 1 (IGF1R) protein expression, mRNA expression and gene copy number in operable non-small cell lung cancer (NSCLC) by Dziadziuszko, R., Merrick, D. T., Witta, S. E., Mendoza, A. D., Szostakiewicz, B., Rzyman, W., Jassem, J., Bunn, P. A., Varella-Garcia, M., Hirsch, F. R.

“…Abstract only 7524 Background: IGF1R is a promising target for NSCLC therapy. We have evaluated IGF1R protein expression, mRNA expression and gene copy number…”
Get full text

Analysis of Orthologous Gene Expression between Human Pulmonary Adenocarcinoma and a Carcinogen-Induced Murine Model by Stearman, Robert S., Dwyer-Nield, Lori, Zerbe, Laura, Blaine, Stacy A., Chan, Zeng, Bunn, Paul A., Johnson, Gary L., Hirsch, Fred R., Merrick, Daniel T., Franklin, Wilbur A., Baron, Anna E., Keith, Robert L., Nemenoff, Raphael A., Malkinson, Alvin M., Geraci, Mark W.

“…Human adenocarcinoma (AC) is the most frequently diagnosed human lung cancer, and its absolute incidence is increasing dramatically. Compared to human lung AC,…”
Get full text

Lethal effects and cardiovascular effects of purified α- and θ-toxins from Clostridium perfringens by STEVENS, D. L, TROYER, B. E, MERRICK, D. T, MITTEN, J. E, OLSON, R. D

“…Shock, a common and frequently fatal manifestation of gas gangrene caused by Clostridium perfringens, is probably mediated by extracellular toxins. Previous…”
Get full text

Lethal Effects and Cardiovascular Effects of Purified  - and  -Toxins from Clostridium perjringens by Stevens, D. L., Troyer, B. E., Merrick, D. T., Mitten, J. E., Olson, R. D.

Get full text

High insulin-like growth factor 1 receptor (IGF1R) expression is associated with poor survival in surgically treated non-small cell lung cancer (NSCLC) patients (pts) by Merrick, D. T., Dziadziuszko, R., Szostakiewicz, B., Szymanowska, A., Rzyman, W., Jassem, E., Jassem, J., Franklin, W. A., Bunn, P. A., Hirsch, F. R.

“…Abstract only 7550 Background: IGF1R represents a novel molecular target in NSCLC. We aimed to evaluate the association between IGF1R expression, clinical…”
Get full text

Analysis of c-erb-1 (EGFR) and c-erb-2 (HER2) expression in bronchial dysplasia: Evaluation of potential targets for chemoprevention of lung cancer by Merrick, D. T., Kittelson, J., Winterhalder, R., Kotantoulas, G., Ingeberg, S., Keith, R. L., Kennedy, T. C., Miller, Y. E., Franklin, W. A., Hirsch, F. R.

“…Abstract only 7070 Background: Lung cancer is preceded by a premalignant phase during which intervention could decrease associated morbidity and mortality…”
Get full text

Analysis of c-ErbB1/Epidermal Growth Factor Receptor and c-ErbB2/HER-2 Expression in Bronchial Dysplasia: Evaluation of Potential Targets for Chemoprevention of Lung Cancer by MERRICK, Daniel T, KITTELSON, John, WINTERHALDER, Ralph, KOTANTOULAS, Georgia, INGEBERG, Steen, KEITH, Robert L, KENNEDY, Timothy C, MILLER, York E, FRANKLIN, Wilbur A, HIRSCH, Fred R

“…Purpose: Lung cancer is preceded by a premalignant phase during which intervention could decrease associated morbidity and mortality. Molecular…”
Get full text

Overexpression of vascular endothelial growth factor and its receptors in bronchial dypslasia demonstrated by quantitative RT-PCR analysis by Merrick, Daniel T., Haney, Jerry, Petrunich, Sheila, Sugita, Michio, Miller, York E., Keith, Robert L., Kennedy, Tim C., Franklin, Wilbur A.

“…Neoangiogenesis is required for the growth of invasive lung carcinoma, however, the role of angiogenesis in the progression of premalignant changes to…”
Get full text

Recent developments in biomarkers for the early detection of lung cancer: perspectives based on publications 2003 to present by Chanin, Thomas D, Merrick, Daniel T, Franklin, Wilbur A, Hirsch, Fred R

“…PURPOSE OF REVIEWGiven the poor prognosis associated with lung cancer, the ability to diagnose lung cancer in its early stages is considered crucial to…”
Get full text