Search Results - "Merolle, Maria"

The B cell receptor signaling pathway in mantle cell lymphoma by Merolle, Maria I, Ahmed, Makhdum, Nomie, Krystle, Wang, Michael L

“…Signal transduction through the constitutively activated B cell receptor (BCR) plays a key role in the pathogenesis of B-cell tumors by promoting survival and…”
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Intestinal cDC1s provide cues required for CD4+ T cell-mediated resistance to Cryptosporidium by Cohn, Ian S, Wallbank, Bethan A, Haskins, Breanne E, O'Dea, Keenan M, Pardy, Ryan D, Shaw, Sebastian, Merolle, Maria I, Gullicksrud, Jodi A, Christian, David A, Striepen, Boris, Hunter, Christopher A

“…Cryptosporidium is an enteric pathogen and a prominent cause of diarrheal disease worldwide. Control of Cryptosporidium requires CD4+ T cells, but how…”
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Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma by Kim, Il-Kyu, Diamond, Mark S., Yuan, Salina, Kemp, Samantha B., Kahn, Benjamin M., Li, Qinglan, Lin, Jeffrey H., Li, Jinyang, Norgard, Robert J., Thomas, Stacy K., Merolle, Maria, Katsuda, Takeshi, Tobias, John W., Baslan, Timour, Politi, Katerina, Vonderheide, Robert H., Stanger, Ben Z.

“…Acquired resistance to immunotherapy remains a critical yet incompletely understood biological mechanism. Here, using a mouse model of pancreatic ductal…”
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Dendritic cell-mediated responses to secreted Cryptosporidium effectors promote parasite-specific CD8+ T cell responses by Haskins, Breanne E., Gullicksrud, Jodi A., Wallbank, Bethan A., Dumaine, Jennifer E., Guérin, Amandine, Cohn, Ian S., O'Dea, Keenan M., Pardy, Ryan D., Merolle, Maria I., Shallberg, Lindsey A., Hunter, Emma N., Byerly, Jessica H., Smith, Eleanor J., Buenconsejo, Gracyn Y., McLeod, Briana I., Christian, David A., Striepen, Boris, Hunter, Christopher A.

“…Cryptosporidium causes debilitating diarrheal disease in patients with primary and acquired defects in T cell function. However, it has been a challenge to…”
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Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy by Metzloff, Ann E., Padilla, Marshall S., Gong, Ningqiang, Billingsley, Margaret M., Han, Xuexiang, Merolle, Maria, Mai, David, Figueroa‐Espada, Christian G., Thatte, Ajay S., Haley, Rebecca M., Mukalel, Alvin J., Hamilton, Alex G., Alameh, Mohamad‐Gabriel, Weissman, Drew, Sheppard, Neil C., June, Carl H., Mitchell, Michael J.

“…Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable clinical success in the treatment of hematological malignancies. However, producing…”
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Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery by Patel, Savan K, Billingsley, Margaret M, Mukalel, Alvin J, Thatte, Ajay S, Hamilton, Alex G, Gong, Ningqiang, El-Mayta, Rakan, Safford, Hannah C, Merolle, Maria, Mitchell, Michael J

“…Lipid nanoparticles (LNPs) have emerged as a viable, clinically-validated platform for the delivery of mRNA therapeutics. LNPs have been utilized as mRNA…”
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Quantifying in situ adaptive immune cell cognate interactions in humans by Liarski, Vladimir M., Sibley, Adam, van Panhuys, Nicholas, Ai, Junting, Chang, Anthony, Kennedy, Domenick, Merolle, Maria, Germain, Ronald N., Giger, Maryellen L., Clark, Marcus R.

“…Two-photon excitation microscopy (TPEM) has revolutionized the understanding of adaptive immunity. However, TPEM usually requires animal models and is not…”
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Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy (Adv. Mater. 26/2024) by Metzloff, Ann E., Padilla, Marshall S., Gong, Ningqiang, Billingsley, Margaret M., Han, Xuexiang, Merolle, Maria, Mai, David, Figueroa‐Espada, Christian G., Thatte, Ajay S., Haley, Rebecca M., Mukalel, Alvin J., Hamilton, Alex G., Alameh, Mohamad‐Gabriel, Weissman, Drew, Sheppard, Neil C., June, Carl H., Mitchell, Michael J.

“…Cancer Immunotherapy In article number 2313226, Ann E. Metzloff, Michael J. Mitchell, and co‐workers develop activating lipid nanoparticles (aLNPs) for cancer…”
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Resistance Mechanisms Underlying Venetoclax Resistance in Mantle Cell Lymphoma by Huang, Shengjian, Jiang, Changying, Guo, Hui, Wang, Jeffrey, Liu, Yang, Li, Carrie, Lopez, Elyse, Zhang, Hui, Lorence, Elizabeth A, Merolle, Maria, Balaji, Swathi, Ahmed, Makhdum, Nomie, Krystle, Zhang, Liang, Wang, Michael

“…Background: BCL-2 is highly expressed in mantle cell lymphoma (MCL), and targeting BCL-2 with venetoclax (ABT-199) has resulted in positive clinical outcomes…”
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Molecular Pathways Associated with Ibrutinib Resistance in Mantle Cell Lymphoma by Zhang, Liang, Nomie, Krystle, Zhang, Shaojun, Liu, Yang, Guo, Hui, Huang, Shengjian, Wang, Jeffrey, Lopez, Elyse, Zhang, Hui, Lorence, Elizabeth A, Merolle, Maria, Balaji, Swathi, Ahmed, Makhdum, Jiang, Changying, Wang, Linghua, Wang, Michael

“…Mantle cell lymphoma (MCL) is an aggressive and incurable subtype of B-cell lymphoma and constitutive activation of the B-cell receptor pathway is a hallmark…”
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FoxM1: A New Therapeutic Target for Mantle Cell Lymphoma by Guo, Hui, Zhang, Hui, Ahmed, Makhdum, Liu, Yang, Huang, Shengjian, Zhang, Victoria, Wang, Jeffrey, Lopez, Elyse, Lorence, Elizabeth A, Wang, Jacqueline, Balaji, Swathi, Maria, Merolle, Jiang, Changying, Nomie, Krystle, Wang, Michael, Zhang, Liang

“…Introduction Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma subtype with elevated B-cell receptor activity. Ibrutinib (IBN), the Bruton's tyrosine…”
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Targeting the Paracaspase MALT1: A Potential Therapy to Overcome Ibrutinib Resistance in Relapsed/Refractory Mantle Cell Lymphoma Patients by Jiang, Changying, Huang, Shengjian, Liu, Yang, Li, Carrie, Guo, Hui, Wang, Jeffrey, Lopez, Elyse, Zhang, Hui, Lorence, Elizabeth A, Merolle, Maria, Balaji, Swathi, Ahmed, Makhdum, Nomie, Krystle, Lin, Xin, Zhang, Liang, Wang, Michael

“…Mantle cell lymphoma (MCL) is an aggressive B cell malignancy that is not yet curable. Ibrutinib was approved in 2013 for the treatment of relapsed/refractory…”
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The Fluorescence detector Array of Single-pixel Telescopes: Contributions to the 35th International Cosmic Ray Conference (ICRC 2017) by Fujii, Toshihiro, Malacari, Max, Albury, Justin, Bellido, Jose A, Farmer, John, Galimova, Aygul, Horvath, Pavel, Hrabovsky, Miroslav, Mandat, Dusan, Matalon, Ariel, Matthews, John N, Merolle, Maria, Ni, Xiaochen, Nozka, Libor, Palatka, Miroslav, Pech, Miroslav, Privitera, Paolo, Schovanek, Petr, Thomas, Stan B, Travnicek, Petr

“…Contributions of the Fluorescence detector Array of Single-pixel Telescopes (FAST) to the 35th International Cosmic Ray Conference, 12-20 July 2017, Busan,…”
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