Quantitative risk assessment of skin sensitising pesticides: Clinical and toxicological considerations
Like many other consumer and occupational products, pesticide formulations may contain active ingredients or co-formulants which have the potential to cause skin sensitisation. Currently, there is little evidence they do, but that could just reflect lack of clinical investigation. Consequently, it i...
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| Published in: | Regulatory toxicology and pharmacology Vol. 144; p. 105493 |
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| Main Authors: | , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier Inc
01-10-2023
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Like many other consumer and occupational products, pesticide formulations may contain active ingredients or co-formulants which have the potential to cause skin sensitisation. Currently, there is little evidence they do, but that could just reflect lack of clinical investigation. Consequently, it is necessary to carry out a safety evaluation process, quantifying risks so that they can be properly managed. A workshop on this topic in 2022 discussed how best to undertake quantitative risk assessment (QRA) for pesticide products, including learning from the experience of industries, notably cosmetics, that already undertake such a process routinely. It also addressed ways to remedy the matter of clinical investigation, even if only to demonstrate the absence of a problem. Workshop participants concluded that QRA for skin sensitisers in pesticide formulations was possible, but required careful justification of any safety factors applied, as well as improvements to the estimation of skin exposure. The need for regulations to stay abreast of the science was also noted. Ultimately, the success of any risk assessment/management for skin sensitisers must be judged by the clinical picture. Accordingly, the workshop participants encouraged the development of more active skin health monitoring amongst groups most exposed to the products.
•Quantitative risk assessment is pre-eminent for skin sensitiser safety evaluation.•Plant protection products may contain sensitising actives and/or co-formulants.•An expert workshop reviewed clinical and toxicological aspects of the issue.•The workshop recommended PPP safety assessment evolve to use QRA.•The workshop noted the paucity of skin allergy to PPPs required an evidence base. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0273-2300 1096-0295 |
| DOI: | 10.1016/j.yrtph.2023.105493 |