Search Results - "Merly, C."

The complex non-genetic inheritance of complex traits by Vogt, Merly C.

“…Merly C. Vogt recalls a seminal paper by Greer et al., who demonstrated the transgenerational inheritance of longevity, a complex trait, in Caenorhabditis…”
Get full text

Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding by Vogt, Merly C., Paeger, Lars, Hess, Simon, Steculorum, Sophie M., Awazawa, Motoharu, Hampel, Brigitte, Neupert, Susanne, Nicholls, Hayley T., Mauer, Jan, Hausen, A. Christine, Predel, Reinhard, Kloppenburg, Peter, Horvath, Tamas L., Brüning, Jens C.

“…Maternal metabolic homeostasis exerts long-term effects on the offspring’s health outcomes. Here, we demonstrate that maternal high-fat diet (HFD) feeding…”
Get full text

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin by Mauer, Jan, Chaurasia, Bhagirath, Goldau, Julia, Vogt, Merly C, Ruud, Johan, Nguyen, Khoa D, Theurich, Sebastian, Hausen, A Christine, Schmitz, Joel, Brönneke, Hella S, Estevez, Emma, Allen, Tamara L, Mesaros, Andrea, Partridge, Linda, Febbraio, Mark A, Chawla, Ajay, Wunderlich, F Thomas, Brüning, Jens C

“…The role of IL-6 in obesity-associated inflammation remains controversial. Bruening and colleagues identify signaling by IL-6 as an important determinant for…”
Get full text

Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment by Wunderlich, Claudia M., Ackermann, P. Justus, Ostermann, Anna Lena, Adams-Quack, Petra, Vogt, Merly C., Tran, My-Ly, Nikolajev, Alexei, Waisman, Ari, Garbers, Christoph, Theurich, Sebastian, Mauer, Jan, Hövelmeyer, Nadine, Wunderlich, F. Thomas

“…Colorectal cancer (CRC) is one of the most lethal cancers worldwide in which the vast majority of cases exhibit little genetic risk but are associated with a…”
Get full text

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue by Steculorum, Sophie M., Ruud, Johan, Karakasilioti, Ismene, Backes, Heiko, Engström Ruud, Linda, Timper, Katharina, Hess, Martin E., Tsaousidou, Eva, Mauer, Jan, Vogt, Merly C., Paeger, Lars, Bremser, Stephan, Klein, Andreas C., Morgan, Donald A., Frommolt, Peter, Brinkkötter, Paul T., Hammerschmidt, Philipp, Benzing, Thomas, Rahmouni, Kamal, Wunderlich, F. Thomas, Kloppenburg, Peter, Brüning, Jens C.

“…Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and chronically altering their activity also affects peripheral…”
Get full text

CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age by Vogt, Merly C, Brüning, Jens C

“…Central nervous system (CNS) insulin signaling regulates energy and glucose homeostasis by acting on hypothalamic neurocircuits and higher brain circuits such…”
Get full text

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b by Kornfeld, Jan-Wilhelm, Baitzel, Catherina, Könner, A. Christine, Nicholls, Hayley T., Vogt, Merly C., Herrmanns, Karolin, Scheja, Ludger, Haumaitre, Cécile, Wolf, Anna M., Knippschild, Uwe, Seibler, Jost, Cereghini, Silvia, Heeren, Joerg, Stoffel, Markus, Brüning, Jens C.

“…The livers of obese mice and humans show increased levels of miR-802 resulting in impaired glucose tolerance and decreased insulin sensitivity through…”
Get full text

Starvation-induced changes in somatic insulin/IGF-1R signaling drive metabolic programming across generations by Vogt, Merly C, Hobert, Oliver

“…Exposure to adverse nutritional and metabolic environments during critical periods of development can exert long-lasting effects on health outcomes of an…”
Get full text

Olfactory Imprinting: A Worm’s Memory of Things Past by Vogt, Merly C., Hobert, Oliver

“…Exposure to distinct stimuli during critical periods of development can affect behavior long-term. A new study in Caenorhabditis elegans demonstrates that…”
Get full text

SLC17A6/7/8 Vesicular Glutamate Transporter Homologs in Nematodes by Serrano-Saiz, Esther, Vogt, Merly C, Levy, Sagi, Wang, Yu, Kaczmarczyk, Karolina K, Mei, Xue, Bai, Ge, Singson, Andrew, Grant, Barth D, Hobert, Oliver

“…Abstract Members of the superfamily of solute carrier (SLC) transmembrane proteins transport diverse substrates across distinct cellular membranes. Three SLC…”
Get full text

Parallel pathways for serotonin biosynthesis and metabolism in C. elegans by Yu, Jingfang, Vogt, Merly C., Fox, Bennett W., Wrobel, Chester J. J., Fajardo Palomino, Diana, Curtis, Brian J., Zhang, Bingsen, Le, Henry H., Tauffenberger, Arnaud, Hobert, Oliver, Schroeder, Frank C.

“…The neurotransmitter serotonin plays a central role in animal behavior and physiology, and many of its functions are regulated via evolutionarily conserved…”
Get full text

WHotLAMP: A simple, inexpensive, and sensitive molecular test for the detection of SARS-CoV-2 in saliva by Ng, David, Pinharanda, Ana, Vogt, Merly C, Litwin-Kumar, Ashok, Stearns, Kyle, Thopte, Urvashi, Cannavo, Enrico, Enikolopov, Armen, Fiederling, Felix, Kosmidis, Stylianos, Noro, Barbara, Rodrigues-Vaz, Ines, Shayya, Hani, Andolfatto, Peter, Peterka, Darcy S, Tabachnik, Tanya, D'Armiento, Jeanine, Goldklang, Monica, Bendesky, Andres

“…Despite the development of effective vaccines against SARS-CoV-2, epidemiological control of the virus is still challenging due to slow vaccine rollouts,…”
Get full text

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity by Timper, Katharina, Paeger, Lars, Sánchez-Lasheras, Carmen, Varela, Luis, Jais, Alexander, Nolte, Hendrik, Vogt, Merly C., Hausen, A. Christine, Heilinger, Christian, Evers, Nadine, Pospisilik, J. Andrew, Penninger, Josef M., Taylor, Eric B., Horvath, Tamas L., Kloppenburg, Peter, Brüning, Jens Claus

“…Mitochondrial oxidative phosphorylation (OXPHOS) and substrate utilization critically regulate the function of hypothalamic proopiomelanocortin…”
Get full text

Publisher Correction: Parallel pathways for serotonin biosynthesis and metabolism in C. elegans by Yu, Jingfang, Vogt, Merly C., Fox, Bennett W., Wrobel, Chester J. J., Fajardo Palomino, Diana, Curtis, Brian J., Zhang, Bingsen, Le, Henry H., Tauffenberger, Arnaud, Hobert, Oliver, Schroeder, Frank C.

Get full text

A neurotransmitter atlas of C. elegans males and hermaphrodites by Wang, Chen, Vidal, Berta, Sural, Surojit, Loer, Curtis, Aguilar, G Robert, Merritt, Daniel M, Toker, Itai Antoine, Vogt, Merly C, Cros, Cyril C, Hobert, Oliver

“…Mapping neurotransmitter identities to neurons is key to understanding information flow in a nervous system. It also provides valuable entry points for…”
Get full text

AgRP Innervation onto POMC Neurons Increases with Age and Is Accelerated with Chronic High-Fat Feeding in Male Mice by Newton, A. Jamila, Hess, Simon, Paeger, Lars, Vogt, Merly C, Fleming Lascano, Jenifer, Nillni, Eduardo A, Brüning, Jens C, Kloppenburg, Peter, Xu, Allison W

“…In many mammals, body weight increases continuously throughout adulthood until late middle age. The hormone leptin is necessary for maintaining body weight, in…”
Get full text

Perinatal programming of metabolic diseases: role of insulin in the development of hypothalamic neurocircuits by Steculorum, Sophie M, Vogt, Merly C, Brüning, Jens C

“…It is increasingly accepted that the metabolic future of an individual can be programmed as early as at developmental stages. For instance, offspring of…”
Get full text

Central insulin signaling modulates hypothalamus–pituitary–adrenal axis responsiveness by Chong, Angie C.N, Vogt, Merly C, Hill, Alexis S, Brüning, Jens C, Zeltser, Lori M

“…Abstract Objective Obesity is often accompanied by hyperactivity of the neuroendocrine stress axis and has been linked to an increased risk of psychiatric…”
Get full text

Single and Transient Ca2+ Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion by Koehler, Sybille, Brähler, Sebastian, Kuczkowski, Alexander, Binz, Julia, Hackl, Matthias J., Hagmann, Henning, Höhne, Martin, Vogt, Merly C., Wunderlich, Claudia M., Wunderlich, F. Thomas, Schweda, Frank, Schermer, Bernhard, Benzing, Thomas, Brinkkoetter, Paul T.

“…Chronic alterations in calcium (Ca 2+ ) signalling in podocytes have been shown to cause proteinuria and progressive glomerular diseases. However, it is…”
Get full text

Effect of finite doses of propylene glycol on enhancement of in vitro percutaneous permeation of loperamide hydrochloride by Trottet, L, Merly, C, Mirza, M, Hadgraft, J, Davis, A.F

“…We hypothesised that the depletion of propylene glycol from topical formulations applied at clinically relevant doses (∼mg/cm 2) would limit its penetration…”
Get full text