Search Results - "Merlo, GR"

Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: Mirror of the past? by Beverdam, Annemiek, Merlo, Giorgio R., Paleari, Laura, Mantero, Stefano, Genova, Francesca, Barbieri, Ottavia, Janvier, Philippe, Levi, Giovanni

“…In modern vertebrates upper and lower jaws are morphologically different. Both develop from the mandibular arch, which is colonized mostly by Hox‐free neural…”
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Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5 by Acampora, D, Merlo, G R, Paleari, L, Zerega, B, Postiglione, M P, Mantero, S, Bober, E, Barbieri, O, Simeone, A, Levi, G

“…The Dlx5 gene encodes a Distal-less-related DNA-binding homeobox protein first expressed during early embryonic development in anterior regions of the mouse…”
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Novel TBX3 mutation data in families with Ulnar–Mammary syndrome indicate a genotype–phenotype relationship: mutations that do not disrupt the T-domain are associated with less severe limb defects by Meneghini, Vasco, Odent, Sylvie, Platonova, Natalia, Egeo, Aliana, Merlo, Giorgio R.

“…We describe a family affected by Ulnar–Mammary syndrome (UMS) in which typical UMS traits (hypoplasia of the breast and axillary hair, upper limbs and genital…”
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The Dlx5 Homeobox Gene Is Essential for Vestibular Morphogenesis in the Mouse Embryo through a BMP4-Mediated Pathway by Merlo, Giorgio R., Paleari, Laura, Mantero, Stefano, Zerega, Barbara, Adamska, Maja, Rinkwitz, Silke, Bober, Eva, Levi, Giovanni

“…In the mouse embryo, Dlx5 is expressed in the otic placode and vesicle, and later in the semicircular canals of the inner ear. In mice homozygous for a null…”
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Multiple functions of Dlx genes by Merlo, G R, Zerega, B, Paleari, L, Trombino, S, Mantero, S, Levi, G

“…Dlx genes comprise a highly conserved family of homeobox genes homologous to the distal-less (Dll) gene of Drosophila. They are thought to act as transcription…”
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Defective neuronogenesis in the absence of Dlx5 by Perera, Marzia, Merlo, Giorgio R, Verardo, Sara, Paleari, Laura, Corte, Giorgio, Levi, Giovanni

“…Dlx genes play an important role in the control of the development of the central nervous system (CNS). Single or compound inactivation of Dlx1, Dlx2, or Dlx5…”
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The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouse by Levi, Giovanni, Puche, Adam C, Mantero, Stefano, Barbieri, Ottavia, Trombino, Sonya, Paleari, Laura, Egeo, Aliana, Merlo, Giorgio R

“…The distalless-related homeogene Dlx5 is expressed in the olfactory placodes and derived tissues and in the anterior-basal forebrain. We investigated the role…”
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Mouse model of split hand/foot malformation type I by Merlo, Giorgio R., Paleari, Laura, Mantero, Stefano, Genova, Francesca, Beverdam, Annemiek, Palmisano, Giulio L., Barbieri, Ottavia, Levi, Giovanni

“…Split hand/foot malformation type I (SHFM1) disease locus maps to chromosome 7q21.3‐q22, a region that includes the distal‐less‐related (dll) genes DLX5 and…”
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PI3K class II α: a novel regulator of vesicular trafficking at the base of the primary cilium by Franco, I, Gulluni, F, Costa, C, Margaria, JP, Campa, CC, De Luca, E, Monteyne, D, Pérez-Morga, D, Boletta, A, Ranghino, A, Merlo, GR, Hirsch, E

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p53-Dependent and p53-Independent Activation of Apoptosis in Mammary Epithelial Cells Reveals a Survival Function of EGF and Insulin by Merlo, Giorgio R., Basolo, Fulvio, Fiore, Lisa, Duboc, Laetitia, Hynes, Nancy E.

“…The p53 tumor suppressor protein has been implicated as a mediator of programmed cell death (PCD). A series of nontransformed mammary epithelial cell (MEC)…”
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Mutations in the p53 gene in primary human breast cancers by OSBORNE, R. J, MERLO, G. R, MINNA, J. D, MITSUDOMI, T, VENESIO, T, LISCIA, D. S, CAPPA, A. P. M, CHIBA, I, TAKAHASHI, T, NAU, M. M, CALLAHAN, R

“…Twenty-six primary breast tumors were examined for mutations in the p53 tumor suppressor gene by an RNase protection assay and nucleotide sequence analysis of…”
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Somatic mutations and human breast cancer. A status report by Callahan, R, Cropp, C S, Merlo, G R, Liscia, D S, Cappa, A P, Lidereau, R

“…A systematic study of primary human breast tumor DNA demonstrated that three proto-oncogenes or regions of the genome (c-myc, int-2, and c-erbB2) are…”
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Growth, differentiation and survival of HC11 mammary epithelial cells: diverse effects of receptor tyrosine kinase-activating peptide growth factors by Merlo, G R, Graus-Porta, D, Cella, N, Marte, B M, Taverna, D, Hynes, N E

“…The HC11 mouse mammary epithelial cells are a useful in vitro model of mammary cell differentiation. When treated with the lactogenic hormones mix…”
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Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation by Levi, Giovanni, Mantero, Stefano, Barbieri, Ottavia, Cantatore, Daniela, Paleari, Laura, Beverdam, Annemiek, Genova, Francesca, Robert, Benoit, Merlo, Giorgio R.

“…Msx and Dlx homeoproteins control the morphogenesis and organization of craniofacial skeletal structures, specifically those derived from the pharyngeal…”
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Growth suppression of normal mammary epithelial cells by wild-type p53 by Merlo, G R, Venesio, T, Taverna, D, Marte, B M, Callahan, R, Hynes, N E

“…p53 mutations are frequent in human breast cancer. In order to understand the role of p53 in the context of the accumulation of mutations in breast cancer, a…”
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Frequent alteration of the DF3 tumor-associated antigen gene in primary human breast carcinomas by MERLO, G. R, JAVED SIDDIQUI, CROPP, C. S, LISCIA, D. S, LIDEREAU, R, CALLAHAN, R, KUFE, D. W

“…The gene for the human DF3 breast carcinoma-associated antigen contains a conserved (G + C)-rich 60-base pair tandem repeat and maps to chromosome 1q21-24. In…”
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In primary human breast carcinomas mutations in exons 5 and 6 of the p53 gene are associated with a high S-phase index by Merlo, G R, Bernardi, A, Diella, F, Venesio, T, Cappa, A P, Callahan, R, Liscia, D S

“…A series of 121 human breast tumors was screened for point mutations in exons 5 through 8 of the p53 gene, by SSCP analysis. On the same tumor samples, the…”
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Loss of heterozygosity on chromosome 17p13 in breast carcinomas identifies tumors with high proliferation index by Merlo, GR, Venesio, T, Bernardi, A, Canale, L, Gaglia, P, Lauro, D, Cappa, AP, Callahan, R, Liscia, DS

“…The capacity of breast tumor cells to proliferate is considered a potential prognostic factor together with other histopathologic parameters. The authors…”
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Genetic and molecular heterogeneity of breast cancer cells by Callahan, R, Cropp, C, Merlo, G R, Diella, F, Venesio, T, Lidereau, R, Cappa, A P, Lisicia, D S

“…We have undertaken a systematic study of primary human breast tumor DNAs to identify and characterize frequently occurring somatic mutations. Loss of…”
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Detection of loss of heterozygosity in tumor DNA samples by PCR by Merlo, G R, Cropp, C S, Callahan, R, Takahashi, T

“…We demonstrate that PCR amplification of human genomic DNA can be used for the detection of loss of heterozygosity (LOH) in tumor samples. A 250-bp fragment…”
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