Search Results - "Merlin Crossley"

Controlling the size of lipid droplets: lipid and protein factors by Yang, Hongyuan, Galea, Anne, Sytnyk, Vladimir, Crossley, Merlin

“…Highlights ► Lipid droplets usually grow by acquiring lipids through targeted delivery and local synthesis. ► Lipid droplets can also grow through fusion, but…”
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Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding by Martyn, Gabriella E., Wienert, Beeke, Yang, Lu, Shah, Manan, Norton, Laura J., Burdach, Jon, Kurita, Ryo, Nakamura, Yukio, Pearson, Richard C. M., Funnell, Alister P. W., Quinlan, Kate G. R., Crossley, Merlin

“…β-hemoglobinopathies such as sickle cell disease (SCD) and β-thalassemia result from mutations in the adult HBB (β-globin) gene. Reactivating the…”
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Methylation of a CGATA element inhibits binding and regulation by GATA-1 by Yang, Lu, Chen, Zhiliang, Stout, Elizabeth S., Delerue, Fabien, Ittner, Lars M., Wilkins, Marc R., Quinlan, Kate G. R., Crossley, Merlin

“…Alterations in DNA methylation occur during development, but the mechanisms by which they influence gene expression remain uncertain. There are few examples…”
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Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin by Masuda, Takeshi, Wang, Xin, Maeda, Manami, Canver, Matthew C., Sher, Falak, Funnell, Alister P. W., Fisher, Chris, Suciu, Maria, Martyn, Gabriella E., Norton, Laura J., Zhu, Catherine, Kurita, Ryo, Nakamura, Yukio, Xu, Jian, Higgs, Douglas R., Crossley, Merlin, Bauer, Daniel E., Orkin, Stuart H., Kharchenko, Peter V., Maeda, Takahiro

“…Genes encoding human β-type globin undergo a developmental switch from embryonic to fetal to adult-type expression. Mutations in the adult form cause inherited…”
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Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3) by Knights, Alexander J., Vohralik, Emily J., Houweling, Peter J., Stout, Elizabeth S., Norton, Laura J., Alexopoulos, Stephanie J., Yik, Jinfen. J., Mat Jusoh, Hanapi, Olzomer, Ellen M., Bell-Anderson, Kim S., North, Kathryn N., Hoehn, Kyle L., Crossley, Merlin, Quinlan, Kate G. R.

“…The conversion of white adipocytes to thermogenic beige adipocytes represents a potential mechanism to treat obesity and related metabolic disorders. However,…”
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Global citizen deliberation on genome editing by Dryzek, John S, Nicol, Dianne, Niemeyer, Simon, Pemberton, Sonya, Curato, Nicole, Bächtiger, André, Batterham, Philip, Bedsted, Bjørn, Burall, Simon, Burgess, Michael, Burgio, Gaetan, Castelfranchi, Yurij, Chneiweiss, Hervé, Church, George, Crossley, Merlin, de Vries, Jantina, Farooque, Mahmud, Hammond, Marit, He, Baogang, Mendonça, Ricardo, Merchant, Jennifer, Middleton, Anna, Rasko, John E J, Van Hoyweghen, Ine, Vergne, Antoine

“…Global governance can be informed by a deliberative assembly composed of lay citizens Genome editing technologies provide vast possibilities for societal…”
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Structural basis for human ZBTB7A action at the fetal globin promoter by Yang, Yang, Ren, Ren, Ly, Lana C., Horton, John R., Li, Fudong, Quinlan, Kate G.R., Crossley, Merlin, Shi, Yunyu, Cheng, Xiaodong

“…Elevated levels of fetal globin protect against β-hemoglobinopathies, such as sickle cell disease and β-thalassemia. Two zinc-finger (ZF) repressors, BCL11A…”
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Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin by Ravi, Nithin Sam, Wienert, Beeke, Wyman, Stacia K, Bell, Henry William, George, Anila, Mahalingam, Gokulnath, Vu, Jonathan T, Prasad, Kirti, Bandlamudi, Bhanu Prasad, Devaraju, Nivedhitha, Rajendiran, Vignesh, Syedbasha, Nazar, Pai, Aswin Anand, Nakamura, Yukio, Kurita, Ryo, Narayanasamy, Muthuraman, Balasubramanian, Poonkuzhali, Thangavel, Saravanabhavan, Marepally, Srujan, Velayudhan, Shaji R, Srivastava, Alok, DeWitt, Mark A, Crossley, Merlin, Corn, Jacob E, Mohankumar, Kumarasamypet M

“…Naturally occurring point mutations in the promoter switch hemoglobin synthesis from defective adult beta-globin to fetal gamma-globin in sickle cell patients…”
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Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways by Ballester, Benoit, Medina-Rivera, Alejandra, Schmidt, Dominic, Gonzàlez-Porta, Mar, Carlucci, Matthew, Chen, Xiaoting, Chessman, Kyle, Faure, Andre J, Funnell, Alister P W, Goncalves, Angela, Kutter, Claudia, Lukk, Margus, Menon, Suraj, McLaren, William M, Stefflova, Klara, Watt, Stephen, Weirauch, Matthew T, Crossley, Merlin, Marioni, John C, Odom, Duncan T, Flicek, Paul, Wilson, Michael D

“…As exome sequencing gives way to genome sequencing, the need to interpret the function of regulatory DNA becomes increasingly important. To test whether…”
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miR-365-3p mediates BCL11A and SOX6 erythroid-specific coregulation: A new player in HbF activation by Simbula, Michela, Manchinu, Maria Francesca, Mingoia, Maura, Pala, Mauro, Asunis, Isadora, Caria, Cristian Antonio, Perseu, Lucia, Shah, Manan, Crossley, Merlin, Moi, Paolo, Ristaldi, Maria Serafina

“…Hemoglobin switching is a complex biological process not yet fully elucidated. The mechanism regulating the suppression of fetal hemoglobin (HbF) expression is…”
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Targeted Disruption of the Basic Krüppel-Like Factor Gene (Klf3) Reveals a Role in Adipogenesis by Sue, Nancy, Jack, Briony H. A., Eaton, Sally A., Pearson, Richard C. M., Funnell, Alister P. W., Turner, Jeremy, Czolij, Robert, Denyer, Gareth, Bao, Shisan, Molero-Navajas, Juan Carlos, Perkins, Andrew, Fujiwara, Yuko, Orkin, Stuart H., Bell-Anderson, Kim, Crossley, Merlin

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The CtBP family: enigmatic and enzymatic transcriptional co-repressors by Turner, Jeremy, Crossley, Merlin

“…Transcription factors that associate with DNA sequences in promoters and enhancers often recruit co‐regulators that modulate their activity. Many of these…”
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Protocols for protein-DNA binding analysis of a zinc finger transcription factor bound to its cognate promoter by Ly, Lana C., Yang, Yang, Li, Fudong, Crossley, Merlin, Shi, Yunyu, Quinlan, Kate G.R.

“…Here, we describe protocols to interrogate the binding of the zinc fingers of the transcription factor ZBTB7A to the fetal γ-globin (HBG) promoter. We detail…”
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Loss of Krüppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/Clqdc2) by BELL-ANDERSON, Kim S, FUNNELL, Alister P, NICHOLAS, Hannah R, SAINSBURY, Amanda, TURNER, Nigel, PEARSON, Richard C, CROSSLEY, Merlin, WILLIAMS, Helen, HANAPI MAT JUSOH, SCULLY, Tiffany, LIM, Wooi F, BURDACH, Jon G, KA SIN MAK, KNIGHTS, Alexander J, HOY, Andrew J

“…Krüppel-like factor 3 (KLF3) is a transcriptional regulator that we have shown to be involved in the regulation of adipogenesis in vitro. Here, we report that…”
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KLF3 Regulates Muscle-Specific Gene Expression and Synergizes with Serum Response Factor on KLF Binding Sites by Himeda, Charis L., Ranish, Jeffrey A., Pearson, Richard C. M., Crossley, Merlin, Hauschka, Stephen D.

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Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1 by Wilkinson-White, Lorna, Gamsjaeger, Roland, Dastmalchi, Siavoush, Wienert, Beeke, Stokes, Philippa H, Crossley, Merlin, Mackay, Joel P, Matthews, Jacqueline M

“…The control of red blood cell and megakaryocyte development by the regulatory protein GATA1 is a paradigm for transcriptional regulation of gene expression in…”
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Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing by Funnell, Alister P W, Mak, Ka Sin, Twine, Natalie A, Pelka, Gregory J, Norton, Laura J, Radziewic, Tania, Power, Melinda, Wilkins, Marc R, Bell-Anderson, Kim S, Fraser, Stuart T, Perkins, Andrew C, Tam, Patrick P, Pearson, Richard C M, Crossley, Merlin

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Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch by Norton, Laura J., Hallal, Samantha, Stout, Elizabeth S., Funnell, Alister P. W., Pearson, Richard C. M., Crossley, Merlin, Quinlan, Kate G. R.

“…The Krüppel-like factor (KLF) family of transcription factors play critical roles in haematopoiesis. KLF1, the founding member of the family, has been…”
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KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells by Norton, Laura J., Funnell, Alister P.W., Burdach, Jon, Wienert, Beeke, Kurita, Ryo, Nakamura, Yukio, Philipsen, Sjaak, Pearson, Richard C.M., Quinlan, Kate G.R., Crossley, Merlin

“…Genes encoding the human β-like hemoglobin proteins undergo a developmental switch from fetal γ-globin to adult β-globin expression around the time of birth…”
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The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo by Funnell, Alister P. W., Norton, Laura J., Mak, Ka Sin, Burdach, Jon, Artuz, Crisbel M., Twine, Natalie A., Wilkins, Marc R., Power, Carl A., Hung, Tzong-Tyng, Perdomo, José, Koh, Philip, Bell-Anderson, Kim S., Orkin, Stuart H., Fraser, Stuart T., Perkins, Andrew C., Pearson, Richard C. M., Crossley, Merlin

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