Search Results - "Merle, Philippe"

Systemic Treatment Options in Hepatocellular Carcinoma by Rimassa, Lorenza, Pressiani, Tiziana, Merle, Philippe

“…Background: Patients with advanced hepatocellular carcinoma (HCC) typically have poor survival outcomes. Until recently, sorafenib was the only systemic…”
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Wnt signaling and hepatocarcinogenesis: Molecular targets for the development of innovative anticancer drugs by Pez, Floriane, Lopez, Anaïs, Kim, Miran, Wands, Jack R, Caron de Fromentel, Claude, Merle, Philippe

“…Summary Hepatocellular carcinoma (HCC) is one of the most common causes of cancer death worldwide. HCC can be cured by radical therapies if early diagnosis is…”
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PLK1 and HOTAIR Accelerate Proteasomal Degradation of SUZ12 and ZNF198 during Hepatitis B Virus-Induced Liver Carcinogenesis by Zhang, Hao, Diab, Ahmed, Fan, Huitao, Mani, Saravana Kumar Kailasam, Hullinger, Ronald, Merle, Philippe, Andrisani, Ourania

“…Elucidating mechanisms of hepatitis B virus (HBV)-mediated hepatocarcinogenesis is needed to gain insights into the etiology and treatment of liver cancer…”
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RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis by Zhang, Hao, Xing, Zheng, Mani, Saravana Kumar Kailasam, Bancel, Brigitte, Durantel, David, Zoulim, Fabien, Tran, Elizabeth J., Merle, Philippe, Andrisani, Ourania

“…Chronic hepatitis B virus (HBV) infection is a major factor in hepatocellular carcinoma (HCC) pathogenesis by a mechanism not yet understood. Elucidating…”
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Deep phenotyping of an international series of patients with late‐onset dysferlinopathy by Fernández‐Eulate, Gorka, Querin, Giorgia, Moore, Ursula, Behin, Anthony, Masingue, Marion, Bassez, Guillaume, Leonard‐Louis, Sarah, Laforêt, Pascal, Maisonobe, Thierry, Merle, Philippe‐Edouard, Spinazzi, Marco, Solé, Guilhem, Kuntzer, Thierry, Bedat‐Millet, Anne‐Laure, Salort‐Campana, Emmanuelle, Attarian, Shahram, Péréon, Yann, Feasson, Leonard, Graveleau, Julie, Nadaj‐Pakleza, Aleksandra, Leturcq, France, Gorokhova, Svetlana, Krahn, Martin, Eymard, Bruno, Straub, Volker, Evangelista, Teresinha, Stojkovic, Tanya

“…Background To describe the clinical, pathological, and molecular characteristics of late‐onset (LO) dysferlinopathy patients. Methods Retrospective series of…”
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Great auricular nerve lesion after interscalenic block: Electrodiagnosis and prognosis by Diab, Eva, Antoun, Ghada, Bonhomme, Samuel, Szurhaj, William, Merle, Philippe

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soCloud: a service-oriented component-based PaaS for managing portability, provisioning, elasticity, and high availability across multiple clouds by Paraiso, Fawaz, Merle, Philippe, Seinturier, Lionel

“…Multi-cloud computing is a promising paradigm to support very large scale world wide distributed applications. Multi-cloud computing is the usage of multiple,…”
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EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes by Mani, Saravana Kumar Kailasam, Zhang, Hao, Diab, Ahmed, Pascuzzi, Pete E, Lefrançois, Lydie, Fares, Nadim, Bancel, Brigitte, Merle, Philippe, Andrisani, Ourania

“…Graphical abstract…”
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Targeted deep sequencing of plasma circulating cell-free DNA reveals Vimentin and Fibulin 1 as potential epigenetic biomarkers for hepatocellular carcinoma by Holmila, Reetta, Sklias, Athena, Muller, David C, Degli Esposti, Davide, Guilloreau, Paule, Mckay, James, Sangrajrang, Suleeporn, Srivatanakul, Petcharin, Hainaut, Pierre, Merle, Philippe, Herceg, Zdenko, Nogueira da Costa, Andre

“…Hepatocellular carcinoma (HCC) is the second most common cause of cancer death worldwide, but is still lacking sensitive and specific biomarkers for early…”
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Case Report: Successful liver transplantation after achieving complete clinical remission of advanced HCC with Atezolizumab plus Bevacizumab combination therapy by Chouik, Yasmina, Erard, Domitille, Demian, Hassan, Schulz, Thomas, Mazard, Tessa, Hartig-Lavie, Kerstin, Antonini, Teresa, Mabrut, Jean-Yves, Mohkam, Kayvan, Rode, Agnès, Merle, Philippe

“…Atezolizumab plus Bevacizumab combination therapy has recently emerged as the new standard of care for unresectable HCC. Significant tumor burden reduction can…”
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Hypersensitivity infusion-associated reactions induced by enzyme replacement therapy in a cohort of patients with late-onset Pompe disease: An experience from the French Pompe Registry by Lessard, Lola E.R., Tard, Céline, Salort-Campana, Emmanuelle, Sacconi, Sabrina, Béhin, Anthony, Bassez, Guillaume, Orlikowski, David, Merle, Philippe, Nollet, Sylvain, Gallay, Laure, Bérard, Frédéric, Robinson, Philip, Bouhour, Françoise, Laforêt, Pascal

“…Pompe disease is a rare hereditary glycogen storage disorder due to lysosomal acid alpha-glucosidase deficiency. Enzyme replacement therapy (ERT) is the only…”
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Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication by Abeywickrama-Samarakoon, Natali, Cortay, Jean-Claude, Sureau, Camille, Müller, Susanne, Alfaiate, Dulce, Guerrieri, Francesca, Chaikuad, Apirat, Schröder, Martin, Merle, Philippe, Levrero, Massimo, Dény, Paul

“…Hepatitis Delta virus (HDV) is a satellite of Hepatitis B virus with a single-stranded circular RNA genome. HDV RNA genome synthesis is carried out in infected…”
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Regorafenib vs. cabozantinib as second-line treatment for advanced hepatocellular carcinoma: an anchored matching-adjusted indirect comparison of efficacy and safety by Philippe Merle, Masatoshi Kudo, Stanimira Krotneva, Kirhan Ozgurdal, Yun Su, Irina Proskorovsky

“…Introduction: The tyrosine kinase inhibitors regorafenib and cabozantinib remain the mainstay in second-line treatment of advanced hepatocellular carcinoma…”
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Comparative Efficacy of Atezolizumab plus Bevacizumab and Other Treatment Options for Patients with Unresectable Hepatocellular Carcinoma: A Network Meta-Analysis by Vogel, Arndt, Rimassa, Lorenza, Sun, Hui-Chan, Abou-Alfa, Ghassan K., El-Khoueiry, Anthony, Pinato, David J., Sanchez Alvarez, Javier, Daigl, Monica, Orfanos, Panos, Leibfried, Michael, Blanchet Zumofen, Marie-Hélène, Gaillard, Vincent E., Merle, Philippe

“…Background: Most phase 3 clinical trials of systemic therapy for first-line unresectable hepatocellular carcinoma (HCC) have failed, with the exception of…”
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Tislelizumab in Patients with Previously Treated Advanced Hepatocellular Carcinoma (RATIONALE-208): A Multicenter, Non-Randomized, Open-Label, Phase 2 Trial by Ren, Zhenggang, Ducreux, Michel, Abou-Alfa, Ghassan K., Merle, Philippe, Fang, Weijia, Edeline, Julien, Li, Zhiwei, Wu, Lihua, Assenat, Eric, Hu, Sheng, Rimassa, Lorenza, Zhang, Tao, Blanc, Jean-Frédéric, Pan, Hongming, Ross, Paul, Yen, Chia-Jui, Tran, Albert, Shao, Guoliang, Bouattour, Mohamed, Chen, Yajin, Meyer, Tim, Hou, Jinlin, Tougeron, David, Bai, Yuxian, Hou, Ming-Mo, Meng, Zhiqiang, Wu, John, Li, Vincent, Chica-Duque, Sandra, Cheng, Ann-Lii

“…Introduction: Tislelizumab (anti-programmed cell death protein 1 antibody) showed preliminary antitumor activity and tolerability in patients with advanced…”
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Second-line cabozantinib after sorafenib treatment for advanced hepatocellular carcinoma: a subgroup analysis of the phase 3 CELESTIAL trial by Kelley, RobinKate, Ryoo, Baek-Yeol, Merle, Philippe, Park, Joong-Won, Bolondi, Luigi, Chan, Stephen L., Lim, HoYeong, Baron, Ari D., Parnis, Francis, Knox, Jennifer, Cattan, Stéphane, Yau, Thomas, Lougheed, Julie C., Milwee, Steven, El-Khoueiry, Anthony B., Cheng, Ann-Lii, Meyer, Tim, Abou-Alfa, Ghassan K.

“…In the phase 3 CELESTIAL trial, cabozantinib improved overall survival (OS) and progression-free survival (PFS) compared with placebo in patients with…”
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Predictive and Prognostic Potential of Liver Function Assessment in Patients with Advanced Hepatocellular Carcinoma: A Systematic Literature Review by Vogel, Arndt, Kelley, Robin K., Johnson, Philip, Merle, Philippe, Yau, Thomas, Kudo, Masatoshi, Meyer, Tim, Rimassa, Lorenza

“…Abstract Introduction: We conducted a systematic literature review to assess the utility of liver function assessments for predicting disease prognosis and…”
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Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma by Nambotin, Sarah Beseme, Lefrancois, Lydie, Sainsily, Xavier, Berthillon, Pascale, Kim, Miran, Wands, Jack R, Chevallier, Michele, Jalinot, Pierre, Scoazec, Jean-Yves, Trepo, Christian, Zoulim, Fabien, Merle, Philippe

“…Background & Aims We previously reported the frequent overexpression of the FZD7 membrane receptor in hepatocellular carcinoma (HCC) and its role for…”
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Statin-associated myasthenia: A case report and literature review by Gras-Champel, Valérie, Masmoudi, Inès, Batteux, Benjamin, Merle, Philippe-Edouard, Liabeuf, Sophie, Masmoudi, Kamel

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Effect of ramucirumab on ALBI grade in patients with advanced HCC: Results from REACH and REACH-2 by Kudo, Masatoshi, Galle, Peter R., Brandi, Giovanni, Kang, Yoon-Koo, Yen, Chia-Jui, Finn, Richard S., Llovet, Josep M., Assenat, Eric, Merle, Philippe, Chan, Stephen L., Palmer, Daniel H., Ikeda, Masafumi, Yamashita, Tatsuya, Vogel, Arndt, Huang, Yi-Hsiang, Abada, Paolo B., Yoshikawa, Reigetsu, Shinozaki, Kenta, Wang, Chunxiao, Widau, Ryan C., Zhu, Andrew X.

“…The albumin–bilirubin (ALBI) grade/score is derived from a validated nomogram to objectively assess prognosis and liver function in patients with…”
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