Search Results - "Merkus, F W H M"

Nasal absorption of hydroxocobalamin in healthy elderly adults by Van Asselt, D. Z. B., Merkus, F. W. H. M., Russel, F. G. M., Hoefnagels, W. H. L.

“…Aims  To investigate the nasal absorption of hydroxocobalamin in 10 healthy elderly adults. Methods  In a cross‐over study, blood samples were collected before…”
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Bioavailability of intranasal formulations of dihydroergotamine by VAN DER KUY, P.-H. M, LOHMAN, J. J. H. M, HOOYMANS, P. M, TER BERG, J. W. M, MERKUS, F. W. H. M

“…A comparison of the pharmacokinetic properties of two novel intranasal preparations of dihydroergotamine mesilate (DHEM) with a commercially available…”
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Population pharmacokinetics of intranasally administered low dose melatonin by Helfrich, E., Neef, C., Merkus, F. W. H. M.

“…Melatonin is an endogenous hormone secreted by the pineal gland and plays a role in the regulation of the circadian rhythms, sleep and mood. Several studies…”
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Nasal drug delivery to the cerebrospinal fluid: transport of a lipophilic compound by MERKUS, P., GUCHELAAR, H. J., RIJN-BIKKER, P. C. VAN, TORANO, J. SASTRE, BOSCH, D. A., MERKUS, F. W. H. M.

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Validation of Animal Experiments on Ciliary Function In Vitro. II. The Influence of Absorption Enhancers, Preservatives and Physiologic Saline by BOEK, W. M, ROMEIJN, S. G, GRAAMANS, K, VERHOEF, J. C, MERKUS, F. W. H. M, HUIZING, E. H

“…Ciliary beat frequency (CBF) is one of the most important parameters of mucociliary clearance. Previously, we demonstrated that mucosa from chicken embryo…”
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The pharmacokinetics of artemisinin after oral, intramuscular and rectal administration to volunteers by Titulaer, H A, Zuidema, J, Kager, P A, Wetsteyn, J C, Lugt, C B, Merkus, F W

“…The pharmacokinetics after oral, intramuscular and rectal administration of artemisinin, a new potent antimalarial drug, to healthy volunteers has been…”
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Methylated ?-cyclodextrins are able to improve the nasal absorption of salmon calcitonin by Schipper, N. G. M., Verhoef, J. C., Romeijn, S. G., Merkus, F. W. H. M.

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Hypocalcemic effect of salmon calcitonin following single and repeated nasal and intravenous administration in young rabbits by SCHIPPER, N. G. M, ROMEIJN, S. G, VERHOEF, J, MERKUS, F. W. H. M

“…The effect of the polypeptide salmon calcitonin (sCT) on serum calcium concentrations following intranasal and intravenous administration was studied in young…”
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Nasal mucociliary clearance as a factor in nasal drug delivery by Marttin, Emmeline, Schipper, Nicolaas G.M, Verhoef, J.Coos, Merkus, Frans W.H.M

“…The nasal mucociliary clearance system transports the mucus layer that covers the nasal epithelium towards the nasopharynx by ciliary beating. Its function is…”
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Transport of peptide and protein drugs across biological membranes by VERHOEF, J. C, BODDE, H. E, DE BOER, A. G, BOUWSTRA, J. A, JUNGINGER, H. E, MERKUS, F. W. H. M, BREIMER, D. D

“…The transport characteristics of peptide and proteins drugs across various epithelial membrane barriers are outlines. These include transport through the…”
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The in vitro and in vivo effect of a new non-halogenated corticosteroid - budesonide - aerosol on human ciliary epithelial function by Duchateau, G S, Zuidema, J, Merkus, F W

“…The in vitro and in vivo effect on the ciliary epithelial function of a new corticosteroid (budesonide), with a high topical and negligible systemic activity,…”
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Effects of N-trimethyl chitosan chloride, a novel absorption enhancer, on Caco-2 intestinal epithelia and the ciliary beat frequency of chicken embryo trachea by Thanou, Maya M, Verhoef, J.Coos, Romeijn, Stefan G, Nagelkerke, J.Fred, Merkus, Frans W.H.M, Junginger, Hans E

“…N-trimethyl chitosan (TMC) polymers are quaternized chitosans in different degrees of trimethylation. These polymers enhance the absorption of macromolecules…”
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Efficacy, Safety and Mechanism of Cyclodextrins as Absorption Enhancers in Nasal Delivery of Peptide and Protein Drugs by Marttin, E., Verhoef, J. C., Merkus, F. W.H.M.

“…Abstract Cyclodextrins are used in nasal drug delivery as absorption enhancing compounds to increase the intranasal bioavailability of peptide and protein…”
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Hydroxocobalamin, a nitric oxide scavenger, in the prophylaxis of migraine: an open, pilot study by van der Kuy, P-H M, Merkus, F W H M, Lohman, J J H M, ter Berg, J W M, Hooymans, P M

“…Drugs which directly counteract nitric oxide (NO), such as endothelial receptor blockers, NO-synthase inhibitors, and NO-scavengers, may be effective in the…”
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Normalization of plasma vitamin B12 concentration by intranasal hydroxocobalamin in vitamin B12-deficient patients by Slot, WB, Merkus, FW, Van Deventer, SJ, Tytgat, GN

“…BACKGROUND & AIMS: Patients with previous stomach and terminal ileum resections are often treated with intramuscular vitamin B12 injections. Disadvantages are,…”
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Effects of absorption enhancers on rat nasal epithelium in vivo : release of marker compounds in the nasal cavity by MARTTIN, E, VERHOEF, J. C, ROMEIJN, S. G, MERKUS, F. W. H. M

“…The assessment of the effects of nasal absorption enhancers on the rat nasal epithelium and membrane permeability in vivo after a single nasal dose of the…”
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The nasal mucociliary clearance : relevance to nasal drug delivery by SHIPPER, N. G. M, COOS VERHOEF, J, MERKUS, F. W. H. M

“…Mucociliary clearance is an important physiological defense mechanism of the respiratory tract to protect the body against noxious inhaled materials. This…”
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The effect of methylated β-cyclodextrins on the tight junctions of the rat nasal respiratory epithelium:: Electron microscopic and confocal laser scanning microscopic visualization studies by Marttin, E, Verhoef, J.C, Spies, F, van der Meulen, J, Nagelkerke, J.F, Koerten, H.K, Merkus, F.W.H.M

“…The nasal absorption enhancer randomly methylated β-cyclodextrin (RAMEB) is thought to increase the paracellular permeability of the nasal epithelium by…”
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Confocal laser scanning microscopic visualization of the transport of dextrans after nasal administration to rats : Effects of absorption enhancers by MARTTIN, E, COOS VERHOEF, J, CULLANDER, C, ROMEIJN, S. G, NAGELKERKE, J. F, MERKUS, F. W. H. M

“…To visualize the transport pathway(s) of high molecular weight model compounds across rat nasal epithelium in vivo using confocal laser scanning microscopy…”
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The influence of absorption enhancers on intranasal insulin absorption in normal and diabetic subjects by MERKUS, F. W. H. M, SCHIPPER, N. G. M, VERHOEF, J. C

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