Search Results - "Merkl, Claudia"

Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs by Leuchs, Simon, Saalfrank, Anja, Merkl, Claudia, Flisikowska, Tatiana, Edlinger, Marlene, Durkovic, Marina, Rezaei, Nousin, Kurome, Mayuko, Zakhartchenko, Valeri, Kessler, Barbara, Flisikowski, Krzysztof, Kind, Alexander, Wolf, Eckhard, Schnieke, Angelika

“…Mutation of the tumor suppressor p53 plays a major role in human carcinogenesis. Here we describe gene-targeted porcine mesenchymal stem cells (MSCs) and live…”
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Generation of functional cardiomyocytes from rat embryonic and induced pluripotent stem cells using feeder-free expansion and differentiation in suspension culture by Dahlmann, Julia, Awad, George, Dolny, Carsten, Weinert, Sönke, Richter, Karin, Fischer, Klaus-Dieter, Munsch, Thomas, Leßmann, Volkmar, Volleth, Marianne, Zenker, Martin, Chen, Yaoyao, Merkl, Claudia, Schnieke, Angelika, Baraki, Hassina, Kutschka, Ingo, Kensah, George

“…The possibility to generate cardiomyocytes from pluripotent stem cells in vitro has enormous significance for basic research, disease modeling, drug…”
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Chemical Conversion of Human Fibroblasts into Functional Schwann Cells by Thoma, Eva C., Merkl, Claudia, Heckel, Tobias, Haab, Rachel, Knoflach, Frederic, Nowaczyk, Corinne, Flint, Nicholas, Jagasia, Ravi, Jensen Zoffmann, Sannah, Truong, Hoa Hue, Petitjean, Pascal, Jessberger, Sebastian, Graf, Martin, Iacone, Roberto

“…Direct transdifferentiation of somatic cells is a promising approach to obtain patient-specific cells for numerous applications. However, conversion across…”
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Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set by Kurome, Mayuko, Geistlinger, Ludwig, Kessler, Barbara, Zakhartchenko, Valeri, Klymiuk, Nikolai, Wuensch, Annegret, Richter, Anne, Baehr, Andrea, Kraehe, Katrin, Burkhardt, Katinka, Flisikowski, Krzysztof, Flisikowska, Tatiana, Merkl, Claudia, Landmann, Martina, Durkovic, Marina, Tschukes, Alexander, Kraner, Simone, Schindelhauer, Dirk, Petri, Tobias, Kind, Alexander, Nagashima, Hiroshi, Schnieke, Angelika, Zimmer, Ralf, Wolf, Eckhard

“…Somatic cell nuclear transfer (SCNT) using genetically engineered donor cells is currently the most widely used strategy to generate tailored pig models for…”
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Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector by Merkl, Claudia, Saalfrank, Anja, Riesen, Nathalie, Kühn, Ralf, Pertek, Anna, Eser, Stefan, Hardt, Markus Sebastian, Kind, Alexander, Saur, Dieter, Wurst, Wolfgang, Iglesias, Antonio, Schnieke, Angelika

“…Current methods of generating rat induced pluripotent stem cells are based on viral transduction of pluripotency inducing genes (Oct4, Sox2, c-myc and Klf4)…”
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A Porcine Model of Familial Adenomatous Polyposis by Flisikowska, Tatiana, Merkl, Claudia, Landmann, Martina, Eser, Stefan, Rezaei, Nousin, Cui, Xinxin, Kurome, Mayuko, Zakhartchenko, Valeri, Kessler, Barbara, Wieland, Hagen, Rottmann, Oswald, Schmid, Roland M, Schneider, Günter, Kind, Alexander, Wolf, Eckhard, Saur, Dieter, Schnieke, Angelika

“…We created gene-targeted pigs with mutations in the adenomatous polyposis coli ( APC ) gene ( APC ) that are orthologous to those responsible for human…”
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Integrative Proteogenomics for Differential Expression and Splicing Variation in a DM1 Mouse Model by Solovyeva, Elizaveta M., Utzinger, Stephan, Vissières, Alexandra, Mitchelmore, Joanna, Ahrné, Erik, Hermes, Erwin, Poetsch, Tania, Ronco, Marie, Bidinosti, Michael, Merkl, Claudia, Serluca, Fabrizio C., Fessenden, James, Naumann, Ulrike, Voshol, Hans, Meyer, Angelika S., Hoersch, Sebastian

“…Dysregulated mRNA splicing is involved in the pathogenesis of many diseases including cancer, neurodegenerative diseases, and muscular dystrophies such as…”
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RNA Interference in Pigs: Comparison of RNAi Test Systems and Expression Vectors by Merkl, Claudia, Leuchs, Simon, Saalfrank, Anja, Kind, Alexander, Schnieke, Angelika

“…We have examined the use of RNA interference as a means of downregulating gene expression and provide the first comparison of shRNA and artificial miRNA…”
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