Search Results - "Merkel, Steven F."

Trafficking of adeno‐associated virus vectors across a model of the blood–brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells by Merkel, Steven F., Andrews, Allison M., Lutton, Evan M., Mu, Dakai, Hudry, Eloise, Hyman, Bradley T., Maguire, Casey A., Ramirez, Servio H.

“…Developing therapies for central nervous system (CNS) diseases is exceedingly difficult because of the blood–brain barrier (BBB). Notably, emerging…”
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Mechanical Injury Induces Brain Endothelial-Derived Microvesicle Release: Implications for Cerebral Vascular Injury during Traumatic Brain Injury by Andrews, Allison M, Lutton, Evan M, Merkel, Steven F, Razmpour, Roshanak, Ramirez, Servio H

“…It is well established that the endothelium responds to mechanical forces induced by changes in shear stress and strain. However, our understanding of vascular…”
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Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists by Ramirez, Servio H., Reichenbach, Nancy L., Fan, Shongshan, Rom, Slava, Merkel, Steven F., Wang, Xu, Ho, Wen‐zhe, Persidsky, Yuri

“…CB2 expression is upregulated in HIV‐1 infected macrophages; CB2 agonists limits infection by inhibition of the HIV‐1‐LTR. Infiltrating monocytes and…”
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Dexamethasone Attenuates the Enhanced Rewarding Effects of Cocaine Following Experimental Traumatic Brain Injury by Merkel, Steven F., Andrews, Allison M., Lutton, Evan M., Razmpour, Roshanak, Cannella, Lee Anne, Ramirez, Servio H.

“…Clinical studies have identified traumatic brain injury (TBI) as a risk factor for the development of cocaine dependence. This claim is supported by our recent…”
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Identification and dynamic regulation of tight junction protein expression in human neural stem cells by Watters, Andrea K, Rom, Slava, Hill, Jeremy D, Dematatis, Marie K, Zhou, Yu, Merkel, Steven F, Andrews, Allison M, Cena, Jonathan, Potula, Raghava, Skuba, Andrew, Son, Young-Jin, Persidsky, Yuri, Ramirez, Servio H

“…Recent reports indicate that neural stem cells (NSCs) exist in a cluster-like formation in close proximity to cerebral microvessels. Similar appearing clusters…”
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Blood biomarkers for brain injury: What are we measuring? by Kawata, Keisuke, Liu, Charles Y., Merkel, Steven F., Ramirez, Servio H., Tierney, Ryan T., Langford, Dianne

“…•Diagnosis for mild TBI remains challenging, as prognosis and return-to-activity decisions are based largely on self-report.•Identifying a blood biomarker to…”
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Gene Therapy for the Nervous System: Challenges and New Strategies by Maguire, Casey A., Ramirez, Servio H., Merkel, Steven F., Sena-Esteves, Miguel, Breakefield, Xandra O.

“…Current clinical treatments for central nervous system (CNS) diseases, such as Parkinson’s disease and glioblastoma do not halt disease progression and have…”
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Factors affecting increased risk for substance use disorders following traumatic brain injury: What we can learn from animal models by Merkel, Steven F., Cannella, Lee Anne, Razmpour, Roshanak, Lutton, Evan, Raghupathi, Ramesh, Rawls, Scott M., Ramirez, Servio H.

“…Effects of traumatic brain injury (TBI) on mechanisms implicated in substance use disorders (SUDs). Recent studies find that TBI may affect many key brain…”
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Characterization of human fetal brain endothelial cells reveals barrier properties suitable for in vitro modeling of the BBB with syngenic co-cultures by Andrews, Allison M, Lutton, Evan M, Cannella, Lee A, Reichenbach, Nancy, Razmpour, Roshanak, Seasock, Matthew J, Kaspin, Steven J, Merkel, Steven F, Langford, Dianne, Persidsky, Yuri, Ramirez, Servio H

“…Endothelial cells (ECs) form the basis of the blood–brain barrier (BBB), a physical barrier that selectively restricts transport into the brain. In vitro…”
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Adolescent Traumatic Brain Injury Induces Chronic Mesolimbic Neuroinflammation with Concurrent Enhancement in the Rewarding Effects of Cocaine in Mice during Adulthood by Merkel, Steven F, Razmpour, Roshanak, Lutton, Evan M, Tallarida, Christopher S, Heldt, Nathan A, Cannella, Lee Anne, Persidsky, Yuri, Rawls, Scott M, Ramirez, Servio H

“…Clinical psychiatric disorders of depression, anxiety, and substance abuse are most prevalent after traumatic brain injury (TBI). Pre-clinical research has…”
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Exosome-associated AAV vector as a robust and convenient neuroscience tool by Hudry, E, Martin, C, Gandhi, S, György, B, Scheffer, D I, Mu, D, Merkel, S F, Mingozzi, F, Fitzpatrick, Z, Dimant, H, Masek, M, Ragan, T, Tan, S, Brisson, A R, Ramirez, S H, Hyman, B T, Maguire, C A

“…Adeno-associated virus (AAV) vectors are showing promise in gene therapy trials and have proven to be extremely efficient biological tools in basic…”
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Trafficking of AAV vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells by Merkel, Steven F., Andrews, Allison M., Lutton, Evan M., Mu, Dakai, Hudry, Eloise, Hyman, Bradley T., Maguire, Casey A., Ramirez, Servio H.

“…Developing therapies for central nervous system (CNS) diseases is exceedingly difficult due to the blood-brain barrier (BBB). Notably, emerging technologies…”
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Effects of Traumatic Brain Injury on Addiction-Like Behavior and Their Neuropathological Correlates by Merkel, Steven F

“…Recent clinical and preclinical reports have identified traumatic brain injury (TBI) as an important risk factor affecting the development of substance use…”
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