Search Results - "Merk, J"

Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex by Ahlfeld, Julia, Filser, Severin, Schmidt, Felix, Wefers, Annika K., Merk, Daniel J., Glaß, Rainer, Herms, Jochen, Schüller, Ulrich

“…We identified a rare undifferentiated cell population that is intermingled with the Bergmann glia of the adult murine cerebellar cortex, expresses the stem…”
Get full text

CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines by Merk, Daniel J, Paul, Linda, Tsiami, Foteini, Hohenthanner, Helen, Kouchesfahani, Ghazal Mohseni, Haeusser, Lara A, Walter, Bianca, Brown, Adam, Persky, Nicole S, Root, David E, Tabatabai, Ghazaleh

“…Genome-wide functional screening using the CRISPR-Cas9 system is a powerful tool to uncover tumor-specific and common genetic dependencies across cancer cell…”
Get full text

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma by Merk, Daniel J., Ohli, Jasmin, Merk, Natalie D., Thatikonda, Venu, Morrissy, Sorana, Schoof, Melanie, Schmid, Susanne N., Harrison, Luke, Filser, Severin, Ahlfeld, Julia, Erkek, Serap, Raithatha, Kaamini, Andreska, Thomas, Weißhaar, Marc, Launspach, Michael, Neumann, Julia E., Shakarami, Mehdi, Plenker, Dennis, Marra, Marco A., Li, Yisu, Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Jones, Steven J.M., Lutz, Beat, Ertl-Wagner, Birgit, Rossi, Andrea, Wagener, Rabea, Siebert, Reiner, Jung, Andreas, Eberhart, Charles G., Lach, Boleslaw, Sendtner, Michael, Pfister, Stefan M., Taylor, Michael D., Chavez, Lukas, Kool, Marcel, Schüller, Ulrich

“…Recurrent mutations in chromatin modifiers are specifically prevalent in adolescent or adult patients with Sonic hedgehog-associated medulloblastoma (SHH MB)…”
Get full text

Functionally-instructed modifiers of response to ATR inhibition in experimental glioma by Walter, Bianca, Hirsch, Sophie, Kuhlburger, Laurence, Stahl, Aaron, Schnabel, Leonard, Wisser, Silas, Haeusser, Lara A, Tsiami, Foteini, Plöger, Sarah, Aghaallaei, Narges, Dick, Advaita M, Skokowa, Julia, Schmees, Christian, Templin, Markus, Schenke-Layland, Katja, Tatagiba, Marcos, Nahnsen, Sven, Merk, Daniel J, Tabatabai, Ghazaleh

“…The DNA damage response (DDR) is a physiological network preventing malignant transformation, e.g. by halting cell cycle progression upon DNA damage detection…”
Get full text

Deficits 10-years after Achilles tendon repair by Horstmann, T, Lukas, C, Merk, J, Brauner, T, Mündermann, A

“…The purpose of this study was to determine the long-term impact of surgical repair and subsequent 6-week immobilization of an Achilles tendon rupture on muscle…”
Get more information

Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma by Tsiami, Foteini, Lago, Chiara, Pozza, Noemi, Piccioni, Federica, Zhao, Xuesong, Lülsberg, Fabienne, Root, David E, Tiberi, Luca, Kool, Marcel, Schittenhelm, Jens, Bandopadhayay, Pratiti, Segal, Rosalind A, Tabatabai, Ghazaleh, Merk, Daniel J

“…Sonic hedgehog subgroup of medulloblastoma (SHH-MB) is characterized by aberrant activation of the SHH signaling pathway. An inhibition of the positive SHH…”
Get full text

Smoking and cancer-related gene expression in bronchial epithelium and non-small-cell lung cancers by Woenckhaus, M, Klein-Hitpass, L, Grepmeier, U, Merk, J, Pfeifer, M, Wild, PJ, Bettstetter, M, Wuensch, P, Blaszyk, H, Hartmann, A, Hofstaedter, F, Dietmaier, W

“…Tobacco smoking is the leading cause of lung cancer worldwide. Gene expression in surgically resected and microdissected samples of non‐small‐cell lung cancers…”
Get full text

Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium by Engel, Nils W, Neumann, Julia E, Ahlfeld, Julia, Wefers, Annika K, Merk, Daniel J, Ohli, Jasmin, Schüller, Ulrich

“…Canonical Wnt signaling is known to promote proliferation of olfactory stem cells. In order to investigate the effects of a constitutive activation of Wnt…”
Get full text

The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors by Merk, Daniel J, Zhou, Pengcheng, Cohen, Samuel M, Pazyra-Murphy, Maria F, Hwang, Grace H, Rehm, Kristina J, Alfaro, Jose, Reid, Christopher M, Zhao, Xuesong, Park, Eunyoung, Xu, Pin-Xian, Chan, Jennifer A, Eck, Michael J, Nazemi, Kellie J, Harwell, Corey C, Segal, Rosalind A

“…During neural development, stem and precursor cells can divide either symmetrically or asymmetrically. The transition between symmetric and asymmetric cell…”
Get more information

Evaluation of potential predictive biomarker for cetuximab in a panel of colorectal cancer patient-derived xenografts (PDX) by Rivera, M, Hoffmann, J, Wulf-Goldenberg, A, Schlag, P.M, Merk, J, Walther, W, Fichtner, I

“…An abstract of a study by Rivera et al evaluating of potential predictive biomarker for cetuximab in a panel of colorectal cancer patient-derived xenografts…”
Get full text

Preclinical Study of a Combination of Erlotinib and Bevacizumab in Early Stages of Unselected Non-Small Cell Lung Cancer Patient-Derived Xenografts by Rolff, J., Becker, M., Merk, J., Hoffmann, J., Fichtner, I.

“…Background The differential outcomes of clinical studies of the targeted therapies for non-small cell lung cancer (NSCLC) indicate that better stratification…”
Get full text

The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration by Schoof, Melanie, Launspach, Michael, Holdhof, Dörthe, Nguyen, Lynhda, Engel, Verena, Filser, Severin, Peters, Finn, Immenschuh, Jana, Hellwig, Malte, Niesen, Judith, Mall, Volker, Ertl-Wagner, Birgit, Hagel, Christian, Spohn, Michael, Lutz, Beat, Sedlacik, Jan, Indenbirken, Daniela, Merk, Daniel J, Schüller, Ulrich

“…CREB (cyclic AMP response element binding protein) binding protein (CBP, CREBBP) is a ubiquitously expressed transcription coactivator with intrinsic histone…”
Get full text

449 Molecular and Therapeutic Characterization of 25 Patient Derived Lung Cancer Tumorgrafts and Analysis for Response Markers to Targeted Therapies as Part of a Systems Biological Approach (PREDICT) by Rolff, J, Becker, M, Yildirimman, R, Isau, M, Hülsmann, H, Kuner, R, Politz, O, Merk, J, Herwig, R, Fichtner, I

Get full text

1149 POSTER Patient-derived Tumourgrafts – Models for a Systemic Cancer Biology Research by Fichtner, I, Becker, M, Rolff, J, Rivera, M, Merk, J, Hoffmann, J

Get full text

Preferential sensitivity to HDAC inhibitors in tumors with CREBBP mutation by Hellwig, Malte, Merk, Daniel J., Lutz, Beat, Schüller, Ulrich

“…Mutations in the gene encoding for the histone acetyltransferase (HAT) CREBBP are common driver events in multiple types of human cancer, such as small cell…”
Get full text

Sonic Hedgehog Signaling is Blue: Insights from the Patched Mutant Mice by Merk, Daniel J., Segal, Rosalind A.

“…The Hedgehog (Hh) pathway is a highly conserved signaling system regulating a range of developmental processes. A 1997 paper by Goodrich and colleagues…”
Get full text

Sustaining Ambulatory Comprehensive Medication Management Practices: Perspectives from a Minnesota Pharmacist Collaborative by Kastner, Mckaya R, Merk, Zachariah J

“…In a time of evolving health care landscapes, pharmacists who provide comprehensive medication management (CMM) need to demonstrate financial and quality value…”
Get full text

TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma by Hellwig, Malte, Lauffer, Marlen C., Bockmayr, Michael, Spohn, Michael, Merk, Daniel J., Harrison, Luke, Ahlfeld, Julia, Kitowski, Annabel, Neumann, Julia E., Ohli, Jasmin, Holdhof, Dörthe, Niesen, Judith, Schoof, Melanie, Kool, Marcel, Kraus, Cornelia, Zweier, Christiane, Holmberg, Dan, Schüller, Ulrich

“…The TCF4 gene encodes for the basic helix–loop–helix transcription factor 4 (TCF4), which plays an important role in the development of the central nervous…”
Get full text

Quantitative assessment of experimental fracture repair by peripheral computed tomography by Augat, P, Merk, J, Genant, H K, Claes, L

“…An experimental fracture model was used to assess bone mineral density at the fracture site by peripheral computed tomography and to compare the model with…”
Get full text

A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors by Neumann, Julia E, Wefers, Annika K, Lambo, Sander, Bianchi, Edoardo, Bockstaller, Marie, Dorostkar, Mario M, Meister, Valerie, Schindler, Pia, Korshunov, Andrey, von Hoff, Katja, Nowak, Johannes, Warmuth-Metz, Monika, Schneider, Marlon R, Renner-Müller, Ingrid, Merk, Daniel J, Shakarami, Mehdi, Sharma, Tanvi, Chavez, Lukas, Glass, Rainer, Chan, Jennifer A, Taketo, M Mark, Neumann, Philipp, Kool, Marcel, Schüller, Ulrich

“…Simultaneous activation of Wnt and Shh pathways in murine neural precursor cells results in the formation of embryonal tumors with multilayered rosettes (ETMR)…”
Get full text