Search Results - "Merjane, Jessica"
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Interferon inhibits the release of herpes simplex virus-1 from the axons of sensory neurons
Published in mBio (31-10-2023)“…Herpes simplex virus-1 (HSV-1) is a human pathogen known to cause cold sores and genital herpes. HSV-1 establishes lifelong infections in our sensory neurons,…”
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2
Harnessing whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation
Published in Nature communications (14-03-2024)“…Developing clinically predictive model systems for evaluating gene transfer and gene editing technologies has become increasingly important in the era of…”
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Novel AAV variants with improved tropism for human Schwann cells
Published in Molecular therapy. Methods & clinical development (13-06-2024)“…Gene therapies and associated technologies are transforming biomedical research and enabling novel therapeutic options for patients living with debilitating…”
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Molecular mechanisms of amyotrophic lateral sclerosis as broad therapeutic targets for gene therapy applications utilizing adeno‐associated viral vectors
Published in Medicinal research reviews (01-07-2023)“…Despite the devastating clinical outcome of the neurodegenerative disease, amyotrophic lateral sclerosis (ALS), its etiology remains mysterious. Approximately…”
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Front Cover Image, Volume 43, Issue 4
Published in Medicinal research reviews (01-07-2023)“…The cover image is based on the Review Article Molecular mechanisms of amyotrophic lateral sclerosis as broad therapeutic targets for gene therapy applications…”
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Development of CNS tropic AAV1-like variants with reduced liver-targeting following systemic administration in mice
Published in Molecular therapy (06-03-2024)“…Directed evolution of natural AAV9 using peptide display libraries have been widely used in the search for an optimal recombinant AAV (rAAV) for transgene…”
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7
ChpC controls twitching motility-mediated expansion of Pseudomonas aeruginosa biofilms in response to serum albumin, mucin and oligopeptides
Published in Microbiology (Society for General Microbiology) (01-07-2020)“…Twitching motility-mediated biofilm expansion occurs via coordinated, multi-cellular collective behaviour to allow bacteria to actively expand across surfaces…”
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Enhanced AAV transduction across preclinical CNS models: A comparative study in human brain organoids with cross-species evaluations
Published in Molecular therapy. Nucleic acids (10-09-2024)“…Viral vectors based on recombinant adeno-associated virus (rAAV) have become the most widely used system for therapeutic gene delivery in the central nervous…”
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