Search Results - "Merino, Lara G"

Target-enriched nanopore sequencing and de novo assembly reveals co-occurrences of complex on-target genomic rearrangements induced by CRISPR-Cas9 in human cells by Geng, Keyi, Merino, Lara G, Wedemann, Linda, Martens, Aniek, Sobota, Małgorzata, Sanchez, Yerma P, Søndergaard, Jonas Nørskov, White, Robert J, Kutter, Claudia

“…The CRISPR-Cas9 system is widely used to permanently delete genomic regions via dual guide RNAs. Genomic rearrangements induced by CRISPR-Cas9 can occur, but…”
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Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy by Giovannucci, Tatiana A., Salomons, Florian A., Stoy, Henriette, Herzog, Laura K., Xu, Shanshan, Qian, Weixing, Merino, Lara G., Gierisch, Maria E., Haraldsson, Martin, Lystad, Alf H., Uvell, Hanna, Simonsen, Anne, Gustavsson, Anna-Lena, Vallin, Michaela, Dantuma, Nico P.

“…The ubiquitin-proteasome system (UPS) and macroautophagy/autophagy are the main proteolytic systems in eukaryotic cells for preserving protein homeostasis,…”
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Intrinsic deletion at 10q23.31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9-mediated genome engineering in HAP1 cells mimicking cancer profiles by Geng, Keyi, Merino, Lara G, Veiga, Raül G, Sommerauer, Christian, Epperlein, Janine, Brinkman, Eva K, Kutter, Claudia

“…The CRISPR-Cas9 system is a powerful tool for studying gene functions and holds potential for disease treatment. However, precise genome editing requires…”
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