Search Results - "Merino, Emilio F."

Metabolomic profiling reveals a finely tuned, starvation-induced metabolic switch in Trypanosoma cruzi epimastigotes by Barisón, María Julia, Rapado, Ludmila Nakamura, Merino, Emilio F., Furusho Pral, Elizabeth Mieko, Mantilla, Brian Suarez, Marchese, Letícia, Nowicki, Cristina, Silber, Ariel Mariano, Cassera, Maria Belen

“…Trypanosoma cruzi, the etiological agent of Chagas disease, is a protozoan parasite with a complex life cycle involving a triatomine insect and mammals…”
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Antiapicoplast and Gametocytocidal Screening To Identify the Mechanisms of Action of Compounds within the Malaria Box by BOWMAN, Jessica D, MERINO, Emilio F, BROOKS, Carrie F, STRIEPEN, Boris, CARLIER, Paul R, CASSERA, Maria B

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Aptamer-Based Imaging of Polyisoprenoids in the Malaria Parasite by Zimbres, Flavia M, Merino, Emilio F, Butschek, Grant J, Butler, Joshua H, Ducongé, Frédéric, Cassera, Maria B

“…Dolichols are isoprenoid end-products of the mevalonate and 2 -methyl-D-erythritol-4-phosphate pathways. The synthesis of dolichols is initiated with the…”
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Metabolic dependency of chorismate in Plasmodium falciparum suggests an alternative source for the ubiquinone biosynthesis precursor by Valenciano, Ana Lisa, Fernández-Murga, Maria L., Merino, Emilio F., Holderman, Nicole R., Butschek, Grant J., Shaffer, Karl J., Tyler, Peter C., Cassera, Maria Belen

“…The shikimate pathway, a metabolic pathway absent in humans, is responsible for the production of chorismate, a branch point metabolite. In the malaria…”
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Comprehensive quantitative analysis of purines and pyrimidines in the human malaria parasite using ion-pairing ultra-performance liquid chromatography–mass spectrometry by Laourdakis, Christian D., Merino, Emilio F., Neilson, Andrew P., Cassera, Maria B.

“…•Quantification of 35 purines and pyrimidines accomplished in a 15min runtime.•Versatility to be customized for other metabolites with similar chemical…”
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Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model by Cassera, María B, Hazleton, Keith Z, Merino, Emilio F, Obaldia, 3rd, Nicanor, Ho, Meng-Chiao, Murkin, Andrew S, DePinto, Richard, Gutierrez, Jemy A, Almo, Steven C, Evans, Gary B, Babu, Yarlagadda S, Schramm, Vern L

“…Plasmodium falciparum causes most of the one million annual deaths from malaria. Drug resistance is widespread and novel agents against new targets are needed…”
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Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity by Frame, I J, Merino, Emilio F, Schramm, Vern L, Cassera, María B, Akabas, Myles H

“…Malaria, caused by Plasmodia parasites, affects hundreds of millions of people. As purine auxotrophs, Plasmodia use transporters to import host purines for…”
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Bioactive Neolignans and Other Compounds from Magnolia grandiflora L.: Isolation and Antiplasmodial Activity by Latif, Abdul, Du, Yongle, Dalal, Seema R., Fernández‐Murga, Maria L., Merino, Emilio F., Cassera, Maria B., Goetz, Michael, Kingston, David G. I.

“…Bioassay‐guided fractionation of a methanol extract of Magnolia grandiflora against Plasmodium falciparum yielded two new (1 and 2) and six known (3 – 8)…”
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Carotenoid Biosynthesis in Intraerythrocytic Stages of Plasmodium falciparum by Tonhosolo, Renata, D’Alexandri, Fabio L., de Rosso, Veridiana V., Gazarini, Marcos L., Matsumura, Miriam Y., Peres, Valnice J., Merino, Emilio F., Carlton, Jane M., Wunderlich, Gerhard, Mercadante, Adriana Z., Kimura, Emília A., Katzin, Alejandro M.

“…Carotenoids are widespread lipophilic pigments synthesized by all photosynthetic organisms and some nonphotosynthetic fungi and bacteria. All carotenoids are…”
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Erythrocytic Adenosine Monophosphate as an Alternative Purine Source in Plasmodium falciparum by Cassera, María B., Hazleton, Keith Z., Riegelhaupt, Paul M., Merino, Emilio F., Luo, Minkui, Akabas, Myles H., Schramm, Vern L.

“…Plasmodium falciparum is a purine auxotroph, salvaging purines from erythrocytes for synthesis of RNA and DNA. Hypoxanthine is the key precursor for purine…”
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The Methylerythritol Phosphate Pathway Is Functionally Active in All Intraerythrocytic Stages of Plasmodium falciparum by Cassera, María B, Gozzo, Fabio C, D'Alexandri, Fabio L, Merino, Emilio F, del Portillo, Hernando A, Peres, Valnice J, Almeida, Igor C, Eberlin, Marcos N, Wunderlich, Gerhard, Wiesner, Jochen, Jomaa, Hassan, Kimura, Emilia A, Katzin, Alejandro M

“…Two genes encoding the enzymes 1-deoxy- d -xylulose-5-phosphate synthase and 1-deoxy- d -xylulose-5-phosphate reductoisomerase have been recently identified,…”
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A High-Affinity Adenosine Kinase from Anopheles gambiae by Cassera, María B, Ho, Meng-Chiao, Merino, Emilio F, Burgos, Emmanuel S, Rinaldo-Matthis, Agnes, Almo, Steven C, Schramm, Vern L

“…Genome analysis revealed a mosquito orthologue of adenosine kinase in Anopheles gambiae (AgAK; the most important vector for the transmission of Plasmodium…”
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Nanomolar Antimalarial Agents against Chloroquine-Resistant Plasmodium falciparum from Medicinal Plants and Their Structure–Activity Relationships by Zhou, Bin, Wu, Yan, Dalal, Seema, Merino, Emilio F., Liu, Qun-Fang, Xu, Cheng-Hui, Yuan, Tao, Ding, Jian, Kingston, David G. I., Cassera, Maria B., Yue, Jian-Min

“…Inspired by the discovery of the antimalarial drug artemisinin from a traditional Chinese medicine (TCM), a natural product library of 44 lindenane-type…”
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Furoquinoline Alkaloids and Methoxyflavones from the Stem Bark of Melicope madagascariensis (Baker) T.G. Hartley by Rasamison, Vincent E., Brodie, Peggy J., Merino, Emilio F., Cassera, Maria B., Ratsimbason, Michel A., Rakotonandrasana, Stephan, Rakotondrafara, Andriamalala, Rafidinarivo, Elie, Kingston, David G. I., Rakotondraibe, Harinantenaina L.

“…Melicope madagascariensis (Rutaceae) is an endemic plant species of Madagascar that was first classified as a member of the genus Euodia J. R. & G. Forst…”
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Lysosomal cholesterol accumulation contributes to the movement phenotypes associated with NUS1 haploinsufficiency by Yu, Seok-Ho, Wang, Tong, Wiggins, Kali, Louie, Raymond J., Merino, Emilio F., Skinner, Cindy, Cassera, Maria B., Meagher, Kirsten, Goldberg, Paul, Rismanchi, Neggy, Chen, Dillon, Lyons, Michael J., Flanagan-Steet, Heather, Steet, Richard

“…Variants in NUS1 are associated with a congenital disorder of glycosylation, developmental and epileptic encephalopathies, and are possible contributors to…”
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Probing the B- & C-rings of the antimalarial tetrahydro-β-carboline MMV008138 for steric and conformational constraints by Ding, Sha, Ghavami, Maryam, Butler, Joshua H., Merino, Emilio F., Slebodnick, Carla, Cassera, Maria B., Carlier, Paul R.

“…[Display omitted] The antimalarial candidate MMV008138 (1a) is of particular interest because its target enzyme (IspD) is absent in human. To achieve higher…”
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Alkyne modified purines for assessment of activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp by Botnar, Alona, Lawrence, Grant, Maher, Steven P., Vantaux, Amélie, Witkowski, Benoît, Shiau, Justine C., Merino, Emilio F., De Vore, David, Yang, Christian, Murray, Cameron, Cassera, Maria B., Leahy, James W., Kyle, Dennis E.

“…[Display omitted] •Plasmodium spp. are purine auxotrophs.•Alkyne modified adenosine, inosine, and hypoxanthine were synthesised to enable copper-catalysed…”
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Comparative genomics of the neglected human malaria parasite Plasmodium vivax by Sargeant, Tobias J, Gueye, Amy H, Salzberg, Steven L, Essien, Kobby, Kooij, Taco W. A, Angiuoli, Samuel V, del Portillo, Hernando A, Gardner, Malcolm J, Nene, Vish, Korsinczky, Michael, Stoeckert, Christian J, Meyer, Esmeralda V.-S, Wortman, Jennifer R, Barnwell, John W, Yamamoto, Marcio M, Crabb, Brendan S, Ralph, Stuart A, Sullivan, Steven A, Coulson, Richard M. R, Merino, Emilio F, Bidwell, Shelby L, Adams, John H, Ren, Qinghu, Fernandez-Becerra, Carmen, Fraser-Liggett, Claire M, Kang'a, Simon, Guo, Xiang, Cheng, Qin, Crabtree, Jonathan, Hoffman, Stephen L, Silva, Joana C, Galinski, Mary R, Caler, Elisabet, Amedeo, Paolo, Paulsen, Ian, Feldblyum, Tamara V, Gilson, Paul R, White, Owen, Lorenzi, Hernan, Carlton, Jane M

“…The human malaria parasite Plasmodium vivax is responsible for 25–40% of the ∼515 million annual cases of malaria worldwide. Although seldom fatal, the…”
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Metabolomics profiling reveals new aspects of dolichol biosynthesis in Plasmodium falciparum by Zimbres, Flavia M., Valenciano, Ana Lisa, Merino, Emilio F., Florentin, Anat, Holderman, Nicole R., He, Guijuan, Gawarecka, Katarzyna, Skorupinska-Tudek, Karolina, Fernández-Murga, Maria L., Swiezewska, Ewa, Wang, Xiaofeng, Muralidharan, Vasant, Cassera, Maria Belen

“…The cis -polyisoprenoid lipids namely polyprenols, dolichols and their derivatives are linear polymers of several isoprene units. In eukaryotes, polyprenols…”
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Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum by Cassera, María B, Merino, Emilio F, Peres, Valnice J, Kimura, Emilia A, Wunderlich, Gerhard, Katzin, Alejandro M

“…In Plasmodium falciparum , the formation of isopentenyl diphosphate and dimethylallyl diphosphate, central intermediates in the biosynthesis of isoprenoids,…”
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