Search Results - "Merigan, William H"

In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous by Dalkara, Deniz, Byrne, Leah C, Klimczak, Ryan R, Visel, Meike, Yin, Lu, Merigan, William H, Flannery, John G, Schaffer, David V

“…Inherited retinal degenerative diseases are a clinically promising focus of adeno-associated virus (AAV)-mediated gene therapy. These diseases arise from…”
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Optogenetic restoration of retinal ganglion cell activity in the living primate by McGregor, Juliette E., Godat, Tyler, Dhakal, Kamal R., Parkins, Keith, Strazzeri, Jennifer M., Bateman, Brittany A., Fischer, William S., Williams, David R., Merigan, William H.

“…Optogenetic therapies for vision restoration aim to confer intrinsic light sensitivity to retinal ganglion cells when photoreceptors have degenerated and light…”
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The susceptibility of the retina to photochemical damage from visible light by Hunter, Jennifer J., Morgan, Jessica I.W., Merigan, William H., Sliney, David H., Sparrow, Janet R., Williams, David R.

“…The photoreceptor/RPE complex must maintain a delicate balance between maximizing the absorption of photons for vision and retinal image quality while…”
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Functional architecture of the foveola revealed in the living primate by McGregor, Juliette E, Yin, Lu, Yang, Qiang, Godat, Tyler, Huynh, Khang T, Zhang, Jie, Williams, David R, Merigan, William H

“…The primate foveola, with its high cone density and magnified cortical representation, is exquisitely specialized for high-resolution spatial vision. However,…”
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All-optical recording and stimulation of retinal neurons in vivo in retinal degeneration mice by Cheong, Soon Keen, Strazzeri, Jennifer M, Williams, David R, Merigan, William H

“…Here we demonstrate the application of a method that could accelerate the development of novel therapies by allowing direct and repeatable visualization of…”
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In vivo-directed evolution of adeno-associated virus in the primate retina by Byrne, Leah C, Day, Timothy P, Visel, Meike, Strazzeri, Jennifer A, Fortuny, Cécile, Dalkara, Deniz, Merigan, William H, Schaffer, David V, Flannery, John G

“…Efficient adeno-associated virus-mediated (AAV-mediated) gene delivery remains a significant obstacle to effective retinal gene therapies. Here, we apply…”
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Intravitreal injection of AAV2 transduces macaque inner retina by Yin, Lu, Greenberg, Kenneth, Hunter, Jennifer J, Dalkara, Deniz, Kolstad, Kathleen D, Masella, Benjamin D, Wolfe, Robert, Visel, Meike, Stone, Daniel, Libby, Richard T, Diloreto, Jr, David, Schaffer, David, Flannery, John, Williams, David R, Merigan, William H

“…Adeno-associated virus serotype 2 (AAV2) has been shown to be effective in transducing inner retinal neurons after intravitreal injection in several species…”
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In vivo chromatic and spatial tuning of foveolar retinal ganglion cells in Macaca fascicularis by Godat, Tyler, Cottaris, Nicolas P, Patterson, Sara, Kohout, Kendall, Parkins, Keith, Yang, Qiang, Strazzeri, Jennifer M, McGregor, Juliette E, Brainard, David H, Merigan, William H, Williams, David R

“…The primate fovea is specialized for high acuity chromatic vision, with the highest density of cone photoreceptors and a disproportionately large…”
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Optogenetic therapy restores retinal activity in primate for at least a year following photoreceptor ablation by McGregor, Juliette E., Kunala, Karteek, Xu, Zhengyang, Murphy, Peter J., Godat, Tyler, Strazzeri, Jennifer M., Bateman, Brittany A., Fischer, William S., Parkins, Keith, Chu, Colin J., Puthussery, Teresa, Williams, David R., Merigan, William H.

“…All retina-based vision restoration approaches rely on the assumption that photoreceptor loss does not preclude reactivation of the remaining retinal…”
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In Vivo Autofluorescence Imaging of the Human and Macaque Retinal Pigment Epithelial Cell Mosaic by Morgan, Jessica I. W, Dubra, Alfredo, Wolfe, Robert, Merigan, William H, Williams, David R

“…Retinal pigment epithelial (RPE) cells are critical for the health of the retina, especially the photoreceptors. A recent study demonstrated that individual…”
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Adaptive optics retinal imaging in the living mouse eye by Geng, Ying, Dubra, Alfredo, Yin, Lu, Merigan, William H, Sharma, Robin, Libby, Richard T, Williams, David R

“…Correction of the eye's monochromatic aberrations using adaptive optics (AO) can improve the resolution of in vivo mouse retinal images [Biss et al., Opt…”
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Imaging light responses of retinal ganglion cells in the living mouse eye by Yin, Lu, Geng, Ying, Osakada, Fumitaka, Sharma, Robin, Cetin, Ali H, Callaway, Edward M, Williams, David R, Merigan, William H

“…This study reports development of a novel method for high-resolution in vivo imaging of the function of individual mouse retinal ganglion cells (RGCs) that…”
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Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy by Hunter, Jennifer J, Masella, Benjamin, Dubra, Alfredo, Sharma, Robin, Yin, Lu, Merigan, William H, Palczewska, Grazyna, Palczewski, Krzysztof, Williams, David R

“…In vivo two-photon imaging through the pupil of the primate eye has the potential to become a useful tool for functional imaging of the retina. Two-photon…”
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In vivo two-photon imaging of the mouse retina by Sharma, Robin, Yin, Lu, Geng, Ying, Merigan, William H, Palczewska, Grazyna, Palczewski, Krzysztof, Williams, David R, Hunter, Jennifer J

“…Though in vivo two-photon imaging has been demonstrated in non-human primates, improvements in the signal-to-noise ratio (SNR) would greatly improve its…”
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The Reduction of Retinal Autofluorescence Caused by Light Exposure by Morgan, Jessica I. W, Hunter, Jennifer J, Merigan, William H, Williams, David R

“…A prior study showed that long exposure to 568-nm light at levels below the maximum permissible exposure safety limit produces retinal damage preceded by a…”
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In-vivo imaging of retinal nerve fiber layer vasculature: imaging histology comparison by Scoles, Drew, Gray, Daniel C, Hunter, Jennifer J, Wolfe, Robert, Gee, Bernard P, Geng, Ying, Masella, Benjamin D, Libby, Richard T, Russell, Stephen, Williams, David R, Merigan, William H

“…Although it has been suggested that alterations of nerve fiber layer vasculature may be involved in the etiology of eye diseases, including glaucoma, it has…”
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Cone-Opponent Ganglion Cells in the Primate Fovea Tuned to Noncardinal Color Directions by Godat, Tyler, Kohout, Kendall, Parkins, Keith, Yang, Qiang, McGregor, Juliette E, Merigan, William H, Williams, David R, Patterson, Sara S

“…A long-standing question in vision science is how the three cone photoreceptor types-long (L), medium (M), and short (S) wavelength sensitive-combine to…”
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Vision science and adaptive optics, the state of the field by Marcos, Susana, Werner, John S., Burns, Stephen A., Merigan, William H., Artal, Pablo, Atchison, David A., Hampson, Karen M., Legras, Richard, Lundstrom, Linda, Yoon, Geungyoung, Carroll, Joseph, Choi, Stacey S., Doble, Nathan, Dubis, Adam M., Dubra, Alfredo, Elsner, Ann, Jonnal, Ravi, Miller, Donald T., Paques, Michel, Smithson, Hannah E., Young, Laura K., Zhang, Yuhua, Campbell, Melanie, Hunter, Jennifer, Metha, Andrew, Palczewska, Grazyna, Schallek, Jesse, Sincich, Lawrence C.

“…Adaptive optics is a relatively new field, yet it is spreading rapidly and allows new questions to be asked about how the visual system is organized. The…”
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Functional Assessment of Vision Restoration by McGregor, Juliette E, Williams, David R, Merigan, William H

“…Despite the many promising therapeutic approaches identified in the laboratory, it has proven extremely challenging to translate basic science advances into…”
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Imaging Retinal Activity in the Living Eye by Hunter, Jennifer J, Merigan, William H, Schallek, Jesse B

“…Retinal function has long been studied with psychophysical methods in humans, whereas detailed functional studies of vision have been conducted mostly in…”
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