Search Results - "Mergny, Jean‐Louis"

Evaluation of the Stability of DNA i‐Motifs in the Nuclei of Living Mammalian Cells by Dzatko, Simon, Krafcikova, Michaela, Hänsel‐Hertsch, Robert, Fessl, Tomas, Fiala, Radovan, Loja, Tomas, Krafcik, Daniel, Mergny, Jean‐Louis, Foldynova‐Trantirkova, Silvie, Trantirek, Lukas

“…C‐rich DNA has the capacity to form a tetra‐stranded structure known as an i‐motif. The i‐motifs within genomic DNA have been proposed to contribute to the…”
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FRET‐MC: A fluorescence melting competition assay for studying G4 structures in vitro by Luo, Yu, Granzhan, Anton, Verga, Daniela, Mergny, Jean‐Louis

“…G‐quadruplexes (G4) play crucial roles in biology, analytical chemistry and nanotechnology. The stability of G4 structures is impacted by the number of…”
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G4Hunter web application: a web server for G-quadruplex prediction by Brázda, Václav, Kolomazník, Jan, Lýsek, Jiří, Bartas, Martin, Fojta, Miroslav, Šťastný, Jiří, Mergny, Jean-Louis

“…Abstract Motivation Expanding research highlights the importance of guanine quadruplex structures. Therefore, easy-accessible tools for quadruplex analyses in…”
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Involvement of G-quadruplex regions in mammalian replication origin activity by Prorok, Paulina, Artufel, Marie, Aze, Antoine, Coulombe, Philippe, Peiffer, Isabelle, Lacroix, Laurent, Guédin, Aurore, Mergny, Jean-Louis, Damaschke, Julia, Schepers, Aloys, Cayrou, Christelle, Teulade-Fichou, Marie-Paule, Ballester, Benoit, Méchali, Marcel

“…Genome-wide studies of DNA replication origins revealed that origins preferentially associate with an Origin G-rich Repeated Element (OGRE), potentially…”
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How long is too long? Effects of loop size on G-quadruplex stability by Guédin, Aurore, Gros, Julien, Alberti, Patrizia, Mergny, Jean-Louis

“…We compared here 80 different sequences containing four tracts of three guanines with loops of variable length (between 1 and 15 bases for unmodified…”
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Thermal and pH Stabilities of i‐DNA: Confronting in vitro Experiments with Models and In‐Cell NMR Data by Cheng, Mingpan, Qiu, Dehui, Tamon, Liezel, Ištvánková, Eva, Víšková, Pavlína, Amrane, Samir, Guédin, Aurore, Chen, Jielin, Lacroix, Laurent, Ju, Huangxian, Trantírek, Lukáš, Sahakyan, Aleksandr B., Zhou, Jun, Mergny, Jean‐Louis

“…Recent studies indicate that i‐DNA, a four‐stranded cytosine‐rich DNA also known as the i‐motif, is actually formed in vivo; however, a systematic study on…”
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Effects of Sequence and Base Composition on the CD and TDS Profiles of i‐DNA by Iaccarino, Nunzia, Cheng, Mingpan, Qiu, Dehui, Pagano, Bruno, Amato, Jussara, Di Porzio, Anna, Zhou, Jun, Randazzo, Antonio, Mergny, Jean‐Louis

“…The i‐motif DNA, also known as i‐DNA, is a non‐canonical DNA secondary structure formed by cytosine‐rich sequences, consisting of two intercalated…”
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DNA Quadruplex Structure with a Unique Cation Dependency by Gajarsky, Martin, Stadlbauer, Petr, Sponer, Jiri, Cucchiarini, Anne, Dobrovolna, Michaela, Brazda, Vaclav, Mergny, Jean‐Louis, Trantirek, Lukas, Lenarcic Zivkovic, Martina

“…DNA quadruplex structures provide an additional layer of regulatory control in genome maintenance and gene expression and are widely used in nanotechnology. We…”
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Aptamer-based Targeted Delivery of a G-quadruplex Ligand in Cervical Cancer Cells by Carvalho, Josué, Paiva, Artur, Cabral Campello, Maria Paula, Paulo, António, Mergny, Jean-Louis, Salgado, Gilmar F., Queiroz, João A., Cruz, Carla

“…AS1411 is a G-rich DNA oligonucleotide that functions as an aptamer of the protein nucleolin, found at high levels on the surface of cancer cells but not on…”
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Meeting report: Seventh International Meeting on Quadruplex Nucleic Acids (Changchun, P.R. China, September 6–9, 2019) by Mergny, Jean-Louis

“…DNA is prone to structural polymorphism: beyond the iconic Watson-Crick double helix, nucleic acids can adopt a number of unusual motifs, at least in vitro…”
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Shape matters: size-exclusion HPLC for the study of nucleic acid structural polymorphism by Largy, Eric, Mergny, Jean-Louis

“…In recent years, an increasing number of reports have been focused on the structure and biological role of non-canonical nucleic acid secondary structures…”
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Structure of two G-quadruplexes in equilibrium in the KRAS promoter by Marquevielle, Julien, Robert, Coralie, Lagrabette, Olivier, Wahid, Mona, Bourdoncle, Anne, Xodo, Luigi E, Mergny, Jean-Louis, Salgado, Gilmar F

“…KRAS is one of the most mutated oncogenes and still considered an undruggable target. An alternative strategy would consist in targeting its gene rather than…”
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Portrait of a Family of Highly Stabilizing and Selective Guanine Quadruplex Platinum(II)‐Based Binders by Miron, Caitlin E., Chen, Mickey, Mergny, Jean‐Louis, Petitjean, Anne

“…The long‐standing history of platinum coordination complexes in nucleic acid recognition attests to the unique suitability of such species for therapeutic…”
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Loop permutation affects the topology and stability of G-quadruplexes by Cheng, Mingpan, Cheng, Yu, Hao, Jingya, Jia, Guoqing, Zhou, Jun, Mergny, Jean-Louis, Li, Can

“…Abstract G-quadruplexes are unusual DNA and RNA secondary structures ubiquitous in a variety of organisms including vertebrates, plants, viruses and bacteria…”
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SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction by Lavigne, Marc, Helynck, Olivier, Rigolet, Pascal, Boudria-Souilah, Rofia, Nowakowski, Mireille, Baron, Bruno, Brülé, Sébastien, Hoos, Sylviane, Raynal, Bertrand, Guittat, Lionel, Beauvineau, Claire, Petres, Stéphane, Granzhan, Anton, Guillon, Jean, Pratviel, Geneviève, Teulade-Fichou, Marie-Paule, England, Patrick, Mergny, Jean-Louis, Munier-Lehmann, Hélène

“…Abstract The multidomain non-structural protein 3 (Nsp3) is the largest protein encoded by coronavirus (CoV) genomes and several regions of this protein are…”
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Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection by Bohálová, Natália, Cantara, Alessio, Bartas, Martin, Kaura, Patrik, Šťastný, Jiří, Pečinka, Petr, Fojta, Miroslav, Mergny, Jean-Louis, Brázda, Václav

“…G-quadruplexes contribute to the regulation of key molecular processes. Their utilization for antiviral therapy is an emerging field of contemporary research…”
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Genome wide distribution of G-quadruplexes and their impact on gene expression in malaria parasites by Gazanion, Elodie, Lacroix, Laurent, Alberti, Patrizia, Gurung, Pratima, Wein, Sharon, Cheng, Mingpan, Mergny, Jean-Louis, Gomes, Ana Rita, Lopez-Rubio, Jose-Juan

“…Mechanisms of transcriptional control in malaria parasites are still not fully understood. The positioning patterns of G-quadruplex (G4) DNA motifs in the…”
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Conjugating a groove-binding motif to an Ir(iii) complex for the enhancement of G-quadruplex probe behavior by Wang, Modi, Mao, Zhifeng, Kang, Tian-Shu, Wong, Chun-Yuen, Mergny, Jean-Louis, Leung, Chung-Hang, Ma, Dik-Lung

“…In this study, the reported G-quadruplex groove binder benzo[ , ]isoquinoline was linked to a cyclometallated Ir(iii) complex to generate a highly selective…”
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Luminescence switch-on detection of protein tyrosine kinase-7 using a G-quadruplex-selective probe by Lin, Sheng, Gao, Wei, Tian, Zeru, Yang, Chao, Lu, Lihua, Mergny, Jean-Louis, Leung, Chung-Hang, Ma, Dik-Lung

“…A series of luminescent iridium(iii) complexes were synthesised and evaluated for their ability to act as luminescent G-quadruplex-selective probes. The…”
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An oxidatively damaged G-quadruplex/hemin DNAzyme by Wang, Jiawei, Cheng, Mingpan, Chen, Jielin, Ju, Huangxian, Monchaud, David, Mergny, Jean-Louis, Zhou, Jun

“…Oxidative damage of guanine to 8-oxoguanine triggers a partial and variable loss of G-quadruplex/hemin DNAzyme activity and provides clues to the mechanistic…”
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