Search Results - "Mergia, Evanthia"

Physiological Functions of NO-Sensitive Guanylyl Cyclase Isoforms by Koesling, Doris, Mergia, Evanthia, Russwurm, Michael

“…NO-sensitive guanylyl cyclase (NO-GC) acts as the receptor for nitric oxide and by the increase in cGMP executes most of the NO effects in the cardiovascular…”
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Nitric oxide/cGMP signaling via guanylyl cyclase isoform 1 modulates glutamate and GABA release in somatosensory cortex of mice by Wang, Qi, Mergia, Evanthia, Koesling, Doris, Mittmann, Thomas

“…•NO-GC1 facilitates presynaptic release of glutamate and GABA via cGMP in somatosensory cortex.•NO/cGMP pathway regulates presynaptic glutamate release through…”
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Fatal Gastrointestinal Obstruction and Hypertension in Mice Lacking Nitric Oxide-Sensitive Guanylyl Cyclase by Friebe, Andreas, Mergia, Evanthia, Dangel, Oliver, Lange, Alexander, Koesling, Doris

“…The signaling molecule nitric oxide (NO), first described as endothelium-derived relaxing factor (EDRF), acts as physiological activator of NO-sensitive…”
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Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP by Yang, Jiangning, Sundqvist, Michaela L, Zheng, Xiaowei, Jiao, Tong, Collado, Aida, Tratsiakovich, Yahor, Mahdi, Ali, Tengbom, John, Mergia, Evanthia, Catrina, Sergiu-Bogdan, Zhou, Zhichao, Carlstrom, Mattias, Akaike, Takaaki, Cortese-Krott, Miriam M, Weitzberg, Eddie, Lundberg, Jon O, Pernow, John

“…Red blood cells (RBCs) mediate cardioprotection via nitric oxide-like bioactivity, but the signaling and the identity of any mediator released by the RBCs…”
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Phosphodiesterase 5 inhibition ameliorates angiotensin II-dependent hypertension and renal vascular dysfunction by Thieme, Manuel, Sivritas, Sema H, Mergia, Evanthia, Potthoff, Sebastian A, Yang, Guang, Hering, Lydia, Grave, Katharina, Hoch, Henning, Rump, Lars C, Stegbauer, Johannes

“…Changes in renal hemodynamics have a major impact on blood pressure (BP). Angiotensin (Ang) II has been shown to induce vascular dysfunction by interacting…”
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Nitrosopersulfide (SSNO(-)) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide by Cortese-Krott, Miriam M, Fernandez, Bernadette O, Santos, José L T, Mergia, Evanthia, Grman, Marian, Nagy, Péter, Kelm, Malte, Butler, Anthony, Feelisch, Martin

“…Sulfide salts are known to promote the release of nitric oxide (NO) from S-nitrosothiols and potentiate their vasorelaxant activity, but much of the cross-talk…”
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More than a Retrograde Messenger: Nitric Oxide Needs Two cGMP Pathways to Induce Hippocampal Long-Term Potentiation by Taqatqeh, Feras, Mergia, Evanthia, Neitz, Angela, Eysel, Ulf T, Koesling, Doris, Mittmann, Thomas

“…Although nitric oxide (NO) has been implicated as a messenger molecule in hippocampal long-term potentiation (LTP) for almost 20 years, its precise function…”
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Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease by Cortese-Krott, Miriam M., Mergia, Evanthia, Kramer, Christian M., Lückstädt, Wiebke, Yang, Jiangning, Wolff, Georg, Panknin, Christina, Bracht, Thilo, Sitek, Barbara, Pernow, John, Stasch, Johannes-Peter, Feelisch, Martin, Koesling, Doris, Kelm, Malte

“…Endothelial dysfunction is associated with decreased NO bioavailability and impaired activation of the NO receptor soluble guanylate cyclase (sGC) in the…”
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cGMP Imaging in Brain Slices Reveals Brain Region-Specific Activity of NO-Sensitive Guanylyl Cyclases (NO-GCs) and NO-GC Stimulators by Peters, Stefanie, Paolillo, Michael, Mergia, Evanthia, Koesling, Doris, Kennel, Lea, Schmidtko, Achim, Russwurm, Michael, Feil, Robert

“…Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl cyclase (NO-GC), of which two isoforms-NO-GC1 and…”
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Modulation of Hyperpolarization-Activated Inward Current and Thalamic Activity Modes by Different Cyclic Nucleotides by Datunashvili, Maia, Chaudhary, Rahul, Zobeiri, Mehrnoush, Lüttjohann, Annika, Mergia, Evanthia, Baumann, Arnd, Balfanz, Sabine, Budde, Björn, van Luijtelaar, Gilles, Pape, Hans-Christian, Koesling, Doris, Budde, Thomas

“…The hyperpolarization-activated inward current, I , plays a key role in the generation of rhythmic activities in thalamocortical (TC) relay neurons. Cyclic…”
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Role of Phosphodiesterase 5 and Cyclic GMP in Hypertension by Mergia, Evanthia, Stegbauer, Johannes

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It takes two to tango: cardiac fibroblast-derived NO-induced cGMP enters cardiac myocytes and increases cAMP by inhibiting PDE3 by Menges, Lukas, Giesen, Jan, Yilmaz, Kerem, Mergia, Evanthia, Füchtbauer, Annette, Füchtbauer, Ernst-Martin, Koesling, Doris, Russwurm, Michael

“…The occurrence of NO/cGMP signalling in cardiac cells is a matter of debate. Recent measurements with a FRET-based cGMP indicator in isolated cardiac cells…”
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Phosphodiesterase 5 attenuates the vasodilatory response in renovascular hypertension by Stegbauer, Johannes, Friedrich, Sebastian, Potthoff, Sebastian A, Broekmans, Kathrin, Cortese-Krott, Miriam M, Quack, Ivo, Rump, Lars Christian, Koesling, Doris, Mergia, Evanthia

“…NO/cGMP signaling plays an important role in vascular relaxation and regulation of blood pressure. The key enzyme in the cascade, the NO-stimulated…”
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Impact of the NO-Sensitive Guanylyl Cyclase 1 and 2 on Renal Blood Flow and Systemic Blood Pressure in Mice by Mergia, Evanthia, Thieme, Manuel, Hoch, Henning, Daniil, Georgios, Hering, Lydia, Yakoub, Mina, Scherbaum, Christina Rebecca, Rump, Lars Christian, Koesling, Doris, Stegbauer, Johannes

“…Nitric oxide (NO) modulates renal blood flow (RBF) and kidney function and is involved in blood pressure (BP) regulation predominantly via stimulation of the…”
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cGMP Catabolism by Phosphodiesterase 5A Regulates Cardiac Adrenergic Stimulation by NOS3-Dependent Mechanism by Takimoto, Eiki, Champion, Hunter C, Belardi, Diego, Moslehi, Javid, Mongillo, Marco, Mergia, Evanthia, Montrose, David C, Isoda, Takayoshi, Aufiero, Kate, Zaccolo, Manuela, Dostmann, Wolfgang R, Smith, Carolyn J, Kass, David A

“…β-Adrenergic agonists stimulate cardiac contractility and simultaneously blunt this response by coactivating NO synthase (NOS3) to enhance cGMP synthesis and…”
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Long-term potentiation in the visual cortex requires both nitric oxide receptor guanylyl cyclases by Haghikia, Arash, Mergia, Evanthia, Friebe, Andreas, Eysel, Ulf T, Koesling, Doris, Mittmann, Thomas

“…The role of nitric oxide (NO)/cGMP signaling in long-term potentiation (LTP) has been a lingering matter of debate. Within the cascade, the NO receptor…”
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Desensitization of NO/cGMP signaling in smooth muscle: blood vessels versus airways by Mullershausen, Florian, Lange, Alexander, Mergia, Evanthia, Friebe, Andreas, Koesling, Doris

“…The NO/cGMP signaling pathway plays a major role in the cardiovascular system, in which it is involved in the regulation of smooth muscle tone and inhibition…”
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Inhibition of Deactivation of NO-sensitive Guanylyl Cyclase Accounts for the Sensitizing Effect of YC-1 by Russwurm, Michael, Mergia, Evanthia, Mullershausen, Florian, Koesling, Doris

“…Many of the physiological effects of the signaling molecule nitric oxide are mediated by the stimulation of the NO-sensitive guanylyl cyclase. Activation of…”
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Role of Phosphodiesterase 5 and Cyclic GMP in Hypertension by Mergia, Evanthia, Stegbauer, Johannes

“…Cyclic GMP (cGMP) is a ubiquitous intracellular second messenger that mediates a wide spectrum of physiologic processes in multiple cell types within the…”
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Hippocampal AMPA‐ and NMDA‐induced cGMP signals are mainly generated by NO‐GC2 and are under tight control by PDEs 1 and 2 by Giesen, Jan, Mergia, Evanthia, Koesling, Doris, Russwurm, Michael

“…In the central nervous system, the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signalling cascade has an established role in fine‐tuning of…”
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