Search Results - "Merg, Celine"

The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts by Lo Sasso, Giuseppe, Phillips, Blaine W., Sewer, Alain, Battey, James N. D., Kondylis, Athanasios, Talikka, Marja, Titz, Bjoern, Guedj, Emmanuel, Peric, Dariusz, Bornand, David, Dulize, Remi, Merg, Celine, Corciulo, Maica, Ouadi, Sonia, Yanuar, Rendy, Tung, Ching Keong, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…Exposure to cigarette smoke (CS) causes detrimental health effects, increasing the risk of cardiovascular, pulmonary diseases and carcinogenesis in exposed…”
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Systems toxicology study reveals reduced impact of heated tobacco product aerosol extract relative to cigarette smoke on premature aging and exacerbation effects in aged aortic cells in vitro by Poussin, Carine, van der Toorn, Marco, Scheuner, Sophie, Piault, Romain, Kondylis, Athanasios, Savioz, Rebecca, Dulize, Rémi, Peric, Dariusz, Guedj, Emmanuel, Maranzano, Fabio, Merg, Celine, Morelli, Moran, Egesipe, Anne-Laure, Johne, Stéphanie, Majeed, Shoaib, Pak, Claudius, Schneider, Thomas, Schlage, Walter K., Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…Aging and smoking are major risk factors for cardiovascular diseases (CVD). Our in vitro study compared, in the context of aging, the effects of the aerosol of…”
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Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids by Nury, Catherine, Merg, Celine, Eb-Levadoux, Yvan, Bovard, David, Porchet, Matthieu, Maranzano, Fabio, Loncarevic, Isidora, Tavalaei, Shahrzad, Lize, Eleonore, Demenescu, Ramona Liliana, Yepiskoposyan, Hasmik, Hoeng, Julia, Ivanov, Nikolai V, Renggli, Kasper, Titz, Bjoern

“…Background: Clozapine is an atypical antipsychotic drug used to treat treatment-resistant schizophrenia. Its side effects, including liver enzyme…”
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A 6-month inhalation toxicology study in Apoe−/− mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract by Wong, Ee Tsin, Szostak, Justyna, Titz, Bjoern, Lee, Tom, Wong, Sin Kei, Lavrynenko, Oksana, Merg, Celine, Corciulo, Maica, Simicevic, Jovan, Auberson, Mehdi, Peric, Dariusz, Dulize, Remi, Bornand, David, Loh, Guo Jie, Lee, Kyeonghee Monica, Zhang, Jingjie, Miller, John H., Schlage, Walter K., Guedj, Emmanuel, Schneider, Thomas, Phillips, Blaine, Leroy, Patrice, Choukrallah, Mohamed Amin, Sierro, Nicolas, Buettner, Ansgar, Xiang, Yang, Kuczaj, Arkadiusz, Ivanov, Nikolai V., Luettich, Karsta, Vanscheeuwijck, Patrick, Peitsch, Manuel C., Hoeng, Julia

“…Cigarette smoking is the major cause of chronic obstructive pulmonary disease. Considerable attention has been paid to the reduced harm potential of…”
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Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis by Ruiz Castro, Pedro A, Kogel, Ulrike, Lo Sasso, Giuseppe, Phillips, Blaine W, Sewer, Alain, Titz, Bjorn, Garcia, Llenalia, Kondylis, Athanasios, Guedj, Emmanuel, Peric, Dariusz, Bornand, David, Dulize, Remi, Merg, Celine, Corciulo, Maica, Ivanov, Nikolai V, Peitsch, Manuel C, Hoeng, Julia

“…Inflammatory bowel disease (IBD) is the collective term for chronic immune-mediated diseases of unknown, multifactorial etiology, arising from the interplay…”
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Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures by Zanetti, Filippo, Sewer, Alain, Mathis, Carole, Iskandar, Anita R, Kostadinova, Radina, Schlage, Walter K, Leroy, Patrice, Majeed, Shoaib, Guedj, Emmanuel, Trivedi, Keyur, Martin, Florian, Elamin, Ashraf, Merg, Céline, Ivanov, Nikolai V, Frentzel, Stefan, Peitsch, Manuel C, Hoeng, Julia

“…Cigarette smoke (CS) has been reported to increase predisposition to oral cancer and is also recognized as a risk factor for many conditions including…”
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Apical Medium Flow Influences the Morphology and Physiology of Human Proximal Tubular Cells in a Microphysiological System by Specioso, Gabriele, Bovard, David, Zanetti, Filippo, Maranzano, Fabio, Merg, Céline, Sandoz, Antonin, Titz, Bjoern, Dalcanale, Federico, Hoeng, Julia, Renggli, Kasper, Suter-Dick, Laura

“…There is a lack of physiologically relevant in vitro human kidney models for disease modelling and detecting drug-induced effects given the limited choice of…”
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3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product by Iskandar, Anita R, Mathis, Carole, Martin, Florian, Leroy, Patrice, Sewer, Alain, Majeed, Shoaib, Kuehn, Diana, Trivedi, Keyur, Grandolfo, Davide, Cabanski, Maciej, Guedj, Emmanuel, Merg, Celine, Frentzel, Stefan, Ivanov, Nikolai V, Peitsch, Manuel C, Hoeng, Julia

“…In vitro toxicology approaches have evolved from a focus on molecular changes within a cell to understanding of toxicity-related mechanisms in systems that can…”
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A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology by Phillips, Blaine W., Schlage, Walter K., Titz, Bjoern, Kogel, Ulrike, Sciuscio, Davide, Martin, Florian, Leroy, Patrice, Vuillaume, Gregory, Krishnan, Subash, Lee, Tom, Veljkovic, Emilija, Elamin, Ashraf, Merg, Celine, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia, Vanscheeuwijck, Patrick

“…Within the framework of a systems toxicology approach, the inhalation toxicity of aerosol from a novel tobacco-heating potentially modified risk tobacco…”
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Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures by Giralt, Albert, Iskandar, Anita R, Martin, Florian, Moschini, Elisa, Serchi, Tomasso, Kondylis, Athanasios, Marescotti, Diego, Leroy, Patrice, Ortega-Torres, Laura, Majeed, Shoaib, Merg, Celine, Trivedi, Keyur, Guedj, Emmanuel, Frentzel, Stefan, Ivanov, Nikolai V., Peitsch, Manuel C, Gutleb, Arno C, Hoeng, Julia

“…[Display omitted] •Biological impact of exposure to an aerosol of an e-vapor device was investigated using human bronchial and alveolar models.•The biological…”
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Assessment of in vitro kinetics and biological impact of nebulized trehalose on human bronchial epithelium by Iskandar, Anita R., Kolli, Aditya Reddy, Giralt, Albert, Neau, Laurent, Fatarova, Maria, Kondylis, Athanasios, Torres, Laura Ortega, Majeed, Shoaib, Merg, Celine, Corciulo, Maica, Trivedi, Keyur, Guedj, Emmanuel, Frentzel, Stefan, Calvino, Florian, Guy, Philippe Alexandre, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…Trehalose is added in drug formulations to act as fillers or improve aerosolization performance. Its characteristics as a carrier molecule have been explored;…”
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The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product by van der Toorn, Marco, Sewer, Alain, Marescotti, Diego, Johne, Stephanie, Baumer, Karin, Bornand, David, Dulize, Remi, Merg, Celine, Corciulo, Maica, Scotti, Elena, Pak, Claudius, Leroy, Patrice, Guedj, Emmanuel, Ivanov, Nikolai, Martin, Florian, Peitsch, Manuel, Hoeng, Julia, Luettich, Karsta

“…Cigarette smoking is the leading cause of preventable lung cancer (LC). Reduction of harmful constituents by heating rather than combusting tobacco may have…”
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A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures by Iskandar, Anita R., Mathis, Carole, Schlage, Walter K., Frentzel, Stefan, Leroy, Patrice, Xiang, Yang, Sewer, Alain, Majeed, Shoaib, Ortega-Torres, Laura, Johne, Stephanie, Guedj, Emmanuel, Trivedi, Keyur, Kratzer, Gilles, Merg, Celine, Elamin, Ashraf, Martin, Florian, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…This study reports a comparative assessment of the biological impact of a heated tobacco aerosol from the tobacco heating system (THS) 2.2 and smoke from a…”
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Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology by Iskandar, Anita R., Zanetti, Filippo, Marescotti, Diego, Titz, Bjorn, Sewer, Alain, Kondylis, Athanasios, Leroy, Patrice, Belcastro, Vincenzo, Torres, Laura Ortega, Acali, Stefano, Majeed, Shoaib, Steiner, Sandro, Trivedi, Keyur, Guedj, Emmanuel, Merg, Celine, Schneider, Thomas, Frentzel, Stefan, Martin, Florian, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…We previously proposed a systems toxicology framework for in vitro assessment of e-liquids. The framework starts with the first layer aimed at screening the…”
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Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5‐week study in A/J mice by Wong, Ee Tsin, Luettich, Karsta, Cammack, Lydia, Chua, Chin Suan, Sciuscio, David, Merg, Celine, Corciulo, Maica, Piault, Romain, Ashutosh, Kumar, Smith, Cameron, Leroy, Patrice, Moine, Fabian, Glabasnia, Anneke, Diana, Pierrick, Chia, Cecilia, Tung, Ching Keong, Ivanov, Nikolai, Hoeng, Julia, Peitsch, Manuel, Lee, Kyeonghee Monica, Vanscheeuwijck, Patrick

“…Most flavors used in e‐liquids are generally recognized as safe for oral consumption, but their potential effects when inhaled are not well characterized. In…”
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A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment by Iskandar, Anita R., Zanetti, Filippo, Kondylis, Athanasios, Martin, Florian, Leroy, Patrice, Majeed, Shoaib, Steiner, Sandro, Xiang, Yang, Ortega Torres, Laura, Trivedi, Keyur, Guedj, Emmanuel, Merg, Celine, Frentzel, Stefan, Ivanov, Nikolai V., Doshi, Utkarsh, Lee, Kyeonghee Monica, McKinney, Willie J., Peitsch, Manuel C., Hoeng, Julia

“…In the context of tobacco harm-reduction strategy, the potential reduced impact of electronic cigarette (EC) exposure should be evaluated relative to the…”
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Corrigendum to “The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product” published in Toxicology in Vitro, Volume 50, August 2018, Pages 95–108 by van der Toorn, Marco, Sewer, Alain, Marescotti, Diego, Johne, Stephanie, Baumer, Karin, Bornand, David, Dulize, Remi, Merg, Celine, Corciulo, Maica, Scotti, Elena, Pak, Claudius, Leroy, Patrice, Guedj, Emmanuel, Ivanov, Nikolai, Martin, Florian, Peitsch, Manuel, Hoeng, Julia, Luettich, Karsta

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The Response of Human Nasal and Bronchial Organotypic Tissue Cultures to Repeated Whole Cigarette Smoke Exposure by Talikka, Marja, Kostadinova, Radina, Xiang, Yang, Mathis, Carole, Sewer, Alain, Majeed, Shoaib, Kuehn, Diana, Frentzel, Stefan, Merg, Celine, Geertz, Marcel, Martin, Florian, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…Exposure to cigarette smoke (CS) is linked to the development of respiratory diseases, and there is a need to understand the mechanisms whereby CS causes…”
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Quantitative proteomics analysis using 2D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modified risk tobacco product on the lung proteome in C57BL/6 mice by Elamin, Ashraf, Titz, Bjoern, Dijon, Sophie, Merg, Celine, Geertz, Marcel, Schneider, Thomas, Martin, Florian, Schlage, Walter K., Frentzel, Stefan, Talamo, Fabio, Phillips, Blaine, Veljkovic, Emilija, Ivanov, Nikolai V., Vanscheeuwijck, Patrick, Peitsch, Manuel C., Hoeng, Julia

“…Smoking is associated with several serious diseases, such as lung cancer and chronic obstructive pulmonary disease (COPD). Within our systems toxicology…”
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Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains by Cabanski, Maciej, Fields, Brett, Boue, Stephanie, Boukharov, Natalia, DeLeon, Hector, Dror, Natalie, Geertz, Marcel, Guedj, Emmanuel, Iskandar, Anita, Kogel, Ulrike, Merg, Celine, Peck, Michael J., Poussin, Carine, Schlage, Walter K., Talikka, Marja, Ivanov, Nikolai V., Hoeng, Julia, Peitsch, Manuel C.

“…Background Mouse models are useful for studying cigarette smoke (CS)-induced chronic pulmonary pathologies such as lung emphysema. To enhance translation of…”
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