Search Results - "Merema, Marjolijn"

Comparison of Biocompatibility and Adsorption Properties of Different Plastics for Advanced Microfluidic Cell and Tissue Culture Models by van Midwoud, Paul M, Janse, Arnout, Merema, Marjolijn T, Groothuis, Geny M. M, Verpoorte, Elisabeth

“…Microfluidic technology is providing new routes toward advanced cell and tissue culture models to better understand human biology and disease. Many advanced…”
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Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies by de Graaf, Inge A M, Olinga, Peter, de Jager, Marina H, Merema, Marjolijn T, de Kanter, Ruben, van de Kerkhof, Esther G, Groothuis, Geny M M

“…Precision-cut tissue slices (PCTS) are viable ex vivo explants of tissue with a reproducible, well defined thickness. They represent a mini-model of the organ…”
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A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices by van Midwoud, Paul M, Merema, Marjolijn T, Verpoorte, Elisabeth, Groothuis, Geny M M

“…Over the past two decades, it has become increasingly clear that the intestine, in addition to the liver, plays an important role in the metabolism of…”
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Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies by van Midwoud, Paul M, Groothuis, Geny M.M, Merema, Marjolijn T, Verpoorte, Elisabeth

“…Early detection of kinetic, metabolic, and toxicity (ADME-Tox) profiles for new drug candidates is of crucial importance during drug development. This article…”
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Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days by Starokozhko, Viktoriia, Vatakuti, Suresh, Schievink, Bauke, Merema, Marjolijn T., Asplund, Annika, Synnergren, Jane, Aspegren, Anders, Groothuis, Geny M. M.

“…Human precision-cut liver slices (hPCLS) are a valuable ex vivo model that can be used in acute toxicity studies. However, a rapid decline in metabolic enzyme…”
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Regional Differences in Human Intestinal Drug Metabolism by Iswandana, Raditya, Irianti, Marina I, Oosterhuis, Dorenda, Hofker, Hendrik S, Merema, Marjolijn T, de Jager, Marina H, Mutsaers, Henricus A M, Olinga, Peter

“…The intestines are key for the absorption of nutrients and water as well as drug metabolism, and it is well known that there are clear differences in the…”
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Human Precision-Cut Liver Slices as an ex Vivo Model to Study Idiosyncratic Drug-Induced Liver Injury by Hadi, Mackenzie, Westra, Inge M, Starokozhko, Viktoriia, Dragovic, Sanja, Merema, Marjolijn T, Groothuis, Geny M. M

“…Idiosyncratic drug-induced liver injury (IDILI) is a major problem during drug development and has caused drug withdrawal and black-box warnings. Because of…”
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Differentiation of human‐induced pluripotent stem cell under flow conditions to mature hepatocytes for liver tissue engineering by Starokozhko, Viktoriia, Hemmingsen, Mette, Larsen, Layla, Mohanty, Soumyaranjan, Merema, Marjolijn, Pimentel, Rodrigo C., Wolff, Anders, Emnéus, Jenny, Aspegren, Anders, Groothuis, Geny, Dufva, Martin

“…Hepatic differentiation of human‐induced pluripotent stem cells (hiPSCs) under flow conditions in a 3D scaffold is expected to be a major step forward for…”
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Viability, function and morphological integrity of precision-cut liver slices during prolonged incubation: Effects of culture medium by Starokozhko, Viktoriia, Abza, Getahun B., Maessen, Hedy C., Merema, Marjolijn T., Kuper, Frieke, Groothuis, Geny M.M.

“…Precision-cut liver slices (PCLS) are an ex vivo model for metabolism and toxicity studies. However, data on the maintenance of the morphological integrity of…”
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Hydrogel embedding of precision-cut liver slices in a microfluidic device improves drug metabolic activity by van Midwoud, Paul M., Merema, Marjolijn T., Verweij, Niek, Groothuis, Geny M.M., Verpoorte, Elisabeth

“…A microfluidic‐based biochip made of poly‐(dimethylsiloxane) was recently reported for the first time by us for the incubation of precision‐cut liver slices…”
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Mouse Precision-Cut Liver Slices as an ex Vivo Model To Study Idiosyncratic Drug-Induced Liver Injury by Hadi, Mackenzie, Chen, Yixi, Starokozhko, Viktoriia, Merema, Marjolijn T, Groothuis, Geny M.M

“…Idiosyncratic drug-induced liver injury (IDILI) has been the top reason for withdrawing drugs from the market or for black box warnings. IDILI may arise from…”
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On-line HPLC Analysis System for Metabolism and Inhibition Studies in Precision-Cut Liver Slices by van Midwoud, Paul M, Janssen, Joost, Merema, Marjolijn T, de Graaf, Inge A. M, Groothuis, Geny M. M, Verpoorte, Elisabeth

“…A novel approach for on-line monitoring of drug metabolism in continuously perifused, precision-cut liver slices (PCLS) in a microfluidic system has been…”
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Erratum to: Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days by Starokozhko, Viktoriia, Vatakuti, Suresh, Schievink, Bauke, Merema, Marjolijn T., Asplund, Annika, Synnergren, Jane, Aspegren, Anders, Groothuis, Geny M. M.

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LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process by Elferink, Marieke G L, Olinga, Peter, Draaisma, Annelies L, Merema, Marjolijn T, Faber, Klaas Nico, Slooff, Maarten J H, Meijer, Dirk K F, Groothuis, Geny M M

“…Endotoxin-induced cholestasis in rodents is caused by hepatic downregulation of transporters, including the basolateral Na+-dependent taurocholate transporter…”
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Precision-Cut Liver Slices as a New Model to Study Toxicity-Induced Hepatic Stellate Cell Activation in a Physiologic Milieu by van de Bovenkamp, Marja, Groothuis, Geny M. M., Draaisma, Annelies L., Merema, Marjolijn T., Bezuijen, Judith I., van Gils, Marit J., Meijer, Dirk K. F., Friedman, Scott L., Olinga, Peter

“…Hepatic stellate cell (HSC) activation is a key event in the natural process of wound healing as well as in fibrosis development in liver. Current in vitro…”
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Organ Slice Viability Extended for Pathway Characterization: An in Vitro Model to Investigate Fibrosis by Vickers, Alison E. M., Saulnier, Muriel, Cruz, Elba, Merema, Marjolijn T., Rose, Kristine, Bentley, Philip, Olinga, Peter

“…Liver slice viability is extended to 96 h for rat, expanding the use of this in vitro model for studying mechanisms of injury and repair, including pathways of…”
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Rat liver slices as a tool to study LPS-induced inflammatory response in the liver by Olinga, Peter, Merema, Marjolijn T, de Jager, Marina H, Derks, Frans, Melgert, Barbro N, Moshage, Han, Slooff, Maarten J.H, Meijer, Dirk K.F, Poelstra, Klaas, Groothuis, Geny M.M

“…Background/Aims : Inflammation in the liver is a complex interaction between parenchymal and non-parenchymal cells, and therefore can not be studied in vitro…”
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The influence of brain death on liver function by Olinga, Peter, Van Der Hoeven, Joost A. B., Merema, Marjolijn T., Freund, Rennie L., Ploeg, Rutger J., Groothuis, Geny M. M.

“…: Background: In this study, we investigated the influence of brain death on inflammatory response and the effects of brain death on liver function both…”
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The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake by Olinga, Peter, Hof, Ingrid H, Merema, Marjolijn T, Smit, Maaike, de Jager, Marina H, Swart, Piet J, Slooff, Maarten J.H, Meijer, Dirk K.F, Groothuis, Geny M.M

“…In the present study we investigated the applicability of the liver slice model to study mechanisms of drug uptake. Four model compounds were investigated that…”
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Effect of Human Liver Source on the Functionality of Isolated Hepatocytes and Liver Slices by OLINGA, P, MEREMA, M, HOF, I. H, DE JONG, K. P, SLOOFF, M. J. H, MEIJER, D. K. F, GROOTHUIS, G. M. M

“…In vitro experiments using human liver tissue to study drug metabolism and transport are usually performed and interpreted without real consideration of the…”
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