Search Results - "Meredith, Timothy C."

On the essentiality of lipopolysaccharide to Gram-negative bacteria by Zhang, Ge, Meredith, Timothy C, Kahne, Daniel

“…Highlights • We discuss the cellular role of lipopolysaccharide within Gram-negative bacteria. • We propose explanations for why lipopolysaccharide is…”
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Wall Teichoic Acid Function, Biosynthesis, and Inhibition by Swoboda, Jonathan G, Campbell, Jennifer, Meredith, Timothy C, Walker, Suzanne

“…Off the wall: Wall teichoic acids (WTAs) are negatively charged glycopolymers found in dense arrays on the surface of Gram‐positive bacteria. WTAs have…”
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Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids by Brown, Stephanie, Xia, Guoqing, Luhachack, Lyly G, Campbell, Jennifer, Meredith, Timothy C, Chen, Calvin, Winstel, Volker, Gekeler, Cordula, Irazoqui, Javier E, Peschel, Andreas, Walker, Suzanne

“…Staphylococcus aureus peptidoglycan (PG) is densely functionalized with anionic polymers called wall teichoic acids (WTAs). These polymers contain three…”
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Multi-strain Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureus by Coe, Kathryn A, Lee, Wonsik, Stone, Madeleine C, Komazin-Meredith, Gloria, Meredith, Timothy C, Grad, Yonatan H, Walker, Suzanne

“…Antibiotic-resistant Staphylococcus aureus remains a leading cause of antibiotic resistance-associated mortality in the United States. Given the reality of…”
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The Extracellular Electron Transport Pathway Reduces Copper for Sensing by the CopRS Two-Component System under Anaerobic Conditions in Listeria monocytogenes by Rizk, Amena A, Komazin, Gloria, Maybin, Michael, Hoque, Nushrat, Weinert, Emily, Meredith, Timothy C

“…The renowned antimicrobial activity of copper stems in part from its ability to undergo redox cycling between Cu oxidation states. Bacteria counter copper…”
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IS1-mediated chromosomal amplification of the arn operon leads to polymyxin B resistance in Escherichia coli B strains by Maybin, Michael, Ranade, Aditi M., Schombel, Ursula, Gisch, Nicolas, Mamat, Uwe, Meredith, Timothy C.

“…Polymyxins [colistin and polymyxin B (PMB)] comprise an important class of natural product lipopeptide antibiotics used to treat multidrug-resistant…”
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A new platform for ultra-high density Staphylococcus aureus transposon libraries by Santiago, Marina, Matano, Leigh M, Moussa, Samir H, Gilmore, Michael S, Walker, Suzanne, Meredith, Timothy C

“…Staphylococcus aureus readily develops resistance to antibiotics and achieving effective therapies to overcome resistance requires in-depth understanding of S…”
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Fatty Acid Biosynthesis in Pseudomonas aeruginosa Is Initiated by the FabY Class of β-Ketoacyl Acyl Carrier Protein Synthases by Yuan, Yanqiu, Sachdeva, Meena, Leeds, Jennifer A, Meredith, Timothy C

“…The prototypical type II fatty acid synthesis (FAS) pathway in bacteria utilizes two distinct classes of β-ketoacyl synthase (KAS) domains to assemble…”
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Pseudomonas aeruginosa Directly Shunts β-Oxidation Degradation Intermediates into De Novo Fatty Acid Biosynthesis by Yuan, Yanqiu, Leeds, Jennifer A, Meredith, Timothy C

“…We identified the fatty acid synthesis (FAS) initiation enzyme in Pseudomonas aeruginosa as FabY, a β-ketoacyl synthase KASI/II domain-containing enzyme that…”
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Late-Stage Polyribitol Phosphate Wall Teichoic Acid Biosynthesis in Staphylococcus aureus by MEREDITH, Timothy C, SWOBODA, Jonathan G, WALKER, Suzanne

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Modification of Lipopolysaccharide with Colanic Acid (M-antigen) Repeats in Escherichia coli by Meredith, Timothy C., Mamat, Uwe, Kaczynski, Zbigniew, Lindner, Buko, Holst, Otto, Woodard, Ronald W.

“…Colanic acid (CA) or M-antigen is an exopolysaccharide produced by many enterobacteria, including the majority of Escherichia coli strains. Unlike other…”
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Deletion of the β-Acetoacetyl Synthase FabY in Pseudomonas aeruginosa Induces Hypoacylation of Lipopolysaccharide and Increases Antimicrobial Susceptibility by SIX, David A, YANQIU YUAN, LEEDS, Jennifer A, MEREDITH, Timothy C

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Streptococcus gordonii Type I Lipoteichoic Acid Contributes to Surface Protein Biogenesis by Lima, Bruno P, Kho, Kelvin, Nairn, Brittany L, Davies, Julia R, Svensäter, Gunnel, Chen, Ruoqiong, Steffes, Amanda, Vreeman, Gerrit W, Meredith, Timothy C, Herzberg, Mark C

“…Lipoteichoic acid (LTA) is an abundant polymer of the Gram-positive bacterial cell envelope and is essential for many species. Whereas the exact function of…”
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Redefining the Requisite Lipopolysaccharide Structure in Escherichia coli by Meredith, Timothy C, Aggarwal, Parag, Mamat, Uwe, Lindner, Buko, Woodard, Ronald W

“…Gram-negative bacteria possess an asymmetric lipid bilayer surrounding the cell wall, the outer membrane (OM). The OM inner leaflet is primarily composed of…”
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WaaA of the Hyperthermophilic Bacterium Aquifex aeolicus Is a Monofunctional 3-Deoxy-d-manno-oct-2-ulosonic Acid Transferase Involved in Lipopolysaccharide Biosynthesis by Mamat, Uwe, Schmidt, Helgo, Munoz, Eva, Lindner, Buko, Fukase, Koichi, Hanuszkiewicz, Anna, Wu, Jing, Meredith, Timothy C., Woodard, Ronald W., Hilgenfeld, Rolf, Mesters, Jeroen R., Holst, Otto

“…The hyperthermophile Aquifex aeolicus belongs to the deepest branch in the bacterial genealogy. Although it has long been recognized that this unique…”
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Salt-Induced Stress Stimulates a Lipoteichoic Acid-Specific Three-Component Glycosylation System in Staphylococcus aureus by Kho, Kelvin, Meredith, Timothy C

“…Lipoteichoic acid (LTA) in is a poly-glycerophosphate polymer anchored to the outer surface of the cell membrane. LTA has numerous roles in cell envelope…”
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Identification of GutQ from Escherichia coli as a d-Arabinose 5-Phosphate Isomerase by MEREDITH, Timothy C, WOODARD, Ronald W

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Bacterial lyso-form lipoproteins are synthesized via an intramolecular acyl chain migration by Armbruster, Krista M., Komazin, Gloria, Meredith, Timothy C.

“…All bacterial lipoproteins share a variably acylated N-terminal cysteine residue. Gram-negative bacterial lipoproteins are triacylated with a thioether-linked…”
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Identification of the Lyso-Form N -Acyl Intramolecular Transferase in Low-GC Firmicutes by Armbruster, Krista M, Meredith, Timothy C

“…Bacterial lipoproteins are embedded in the cell membrane of both Gram-positive and Gram-negative bacteria, where they serve numerous functions central to cell…”
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Copper-Induced Expression of a Transmissible Lipoprotein Intramolecular Transacylase Alters Lipoprotein Acylation and the Toll-Like Receptor 2 Response to Listeria monocytogenes by Armbruster, Krista M, Komazin, Gloria, Meredith, Timothy C

“…Bacterial lipoproteins are globular proteins anchored to the extracytoplasmic surfaces of cell membranes through lipidation at a conserved N-terminal cysteine…”
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