Search Results - "Meredith, Gavin D."

Glycogen synthase kinase-3 (Gsk-3) plays a fundamental role in maintaining DNA methylation at imprinted loci in mouse embryonic stem cells by Meredith, Gavin D, D'Ippolito, Anthony, Dudas, Miroslav, Zeidner, Leigh C, Hostetter, Logan, Faulds, Kelsie, Arnold, Thomas H, Popkie, Anthony P, Doble, Bradley W, Marnellos, George, Adams, Christopher, Wang, Yulei, Phiel, Christopher J

“…Glycogen synthase kinase-3 (Gsk-3) is a key regulator of multiple signal transduction pathways. Recently we described a novel role for Gsk-3 in the regulation…”
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An alignment algorithm for bisulfite sequencing using the Applied Biosystems SOLiD System by Ondov, Brian D., Cochran, Charles, Landers, Mark, Meredith, Gavin D., Dudas, Miroslav, Bergman, Nicholas H.

“…Bisulfite sequencing allows cytosine methylation, an important epigenetic marker, to be detected via nucleotide substitutions. Since the Applied Biosystems…”
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Targeted Protein Functionalization Using His-Tags by Meredith, Gavin D, Wu, Hayley Y, Allbritton, Nancy L

“…With the impressive growth in gene sequence data that has become available, recombinant proteins represent an increasingly vast source of molecular components,…”
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Measurement of kinase activation in single mammalian cells by Allbritton, Nancy L, Meredith, Gavin D, Sims, Christopher E, Soughayer, Joseph S

“…We demonstrate a new method for the simultaneous measurement of the activation of key regulatory enzymes within single cells. To illustrate the capabilities of…”
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Paediatric leukaemia DNA methylation profiling using MBD enrichment and SOLiD sequencing on archival bone marrow smears by Wong, Nicholas Cl, Meredith, Gavin D, Marnellos, George, Dudas, Miroslav, Parkinson-Bates, Mandy, Halemba, Minhee Suh, Chatterton, Zac, Maksimovic, Jovana, Ashley, David M, Mechinaud, Francoise, Craig, Jeffrey M, Saffery, Richard

“…Acute Lymphoblastic Leukaemia (ALL) is the most common cancer in children. Over the past four decades, research has advanced the treatment of this cancer from…”
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Laser−Micropipet Combination for Single-Cell Analysis by Sims, Christopher E, Meredith, Gavin D, Krasieva, Tatiana B, Berns, Michael W, Tromberg, Bruce J, Allbritton, Nancy L

“…Due to its potential for exquisite mass detection limits and resolving power, capillary electrophoresis is used for biochemical measurements on single cells;…”
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Electron Crystal Structure of an RNA Polymerase II Transcription Elongation Complex by Poglitsch, Claudia L, Meredith, Gavin D, Gnatt, Averell L, Jensen, Grant J, Chang, Wei-hau, Fu, Jianhua, Kornberg, Roger D

“…The structure of an actively transcribing complex, containing yeast RNA polymerase II with associated template DNA and product RNA, was determined by electron…”
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Two conformations of RNA polymerase II revealed by electron crystallography by Asturias, Francisco J, Meredith, Gavin D, Poglitsch, Claudia L, Kornberg, Roger D

“…A new two-dimensional crystal form of yeast RNA polymerase II was obtained in which the conformation of the enzyme appears “open”, allowing entry of DNA, as…”
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Analytical Validation of a Duplex Sequencing AML Assay with a Limit of Detection Below 0.01% VAF for SNVs and Indels by McElwain, Mark A., Olson, Janice M., Zanette, Camila, Nguyen, Karen, Fitzgerald, Devon M., Lee, Isabel Y., Schmidt, Elizabeth, Vavra, Kevin C., Gillis, Laura B., Gordon, Kelly J., Wakeman, Wayne B., Smith, Thomas H., Salk, Jesse J., Higgins, Jake, Harrell, Jill C., Chu, Frances, Meredith, Gavin D.

“…Sensitive, specific, precise, and accurate detection of low frequency mutations in acute myeloid leukemia (AML) is critical to assess measurable residual…”
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Abstract LB254: Accurate detection of low frequency AML-associated mutations in vitro using Duplex Sequencing with enzymatic fragmentation by Schmidt, Elizabeth, Fitzgerald, Devon M., Zanette, Camila, Meredith, Gavin D., McElwain, Mark A., Burciaga, Raul, Vavra, Kevin C., Smith, Thomas H., Salk, Jesse J., Higgins, Jake

“…Sensitive and specific detection of low frequency mutations in acute myeloid leukemia (AML) is critical in research of minimal residual disease (MRD). At…”
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An AML Targeted Duplex Sequencing Assay That Can Detect Measurable Residual Disease (MRD) at a Sensitivity Better Than 0.01% Variant Allele Frequency by McElwain, Mark, Olson, Janice M, Zannette, Camila, Nguyen, Karen, Fitzgerald, Devon M, Lee, Isabel Y, Schmidt, Elizabeth, Vavra, Kevin C, Gillis, Laura B, Gordon, Kelly J, Wakeman, Wayne B, Smith, Thomas H, Salk, Jesse J, Higgins, Jake, Harrell, Jill C, Chu, Frances, Meredith, Gavin D

“…The majority of acute myeloid leukemia (AML) patients relapse after initially achieving remission following conventional therapies. Measurable residual disease…”
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Abstract LB-133: Genome-wide differences in DNA methylation between tumor and normal adjacent tissue mapped by high-throughput sequencing of methyl-CPG binding domain based affinity-purified genomic fragments by Meredith, Gavin D., Dudas, Miroslav, Krissinger, Daniel, Marnellos, George, Adams, Christopher

“…Aberrant DNA methylation is characteristic of many cancers and differences in methylation have been observed in a wide variety of genomic contexts; for…”
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The C-terminal Domain Revealed in the Structure of RNA Polymerase II by Meredith, Gavin D., Chang, Wei-Hau, Li, Yang, Bushnell, David A., Darst, Seth A., Kornberg, Roger D.

“…The location of the CTD in the structure of RNA polymerase II has been determined by electron crystallography at 16 Å resolution. Difference maps between…”
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