Search Results - "Merdan, T."

Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments by MERDAN, Thomas, KUNATH, Klaus, FISCHER, Dagmar, KOPECEK, Jindrich, KISSEL, Thomas

“…Critical steps in the subcellular processing of poly(ethylene imine)/nucleic acid complexes, especially endosomal/lysosomal escape, were visualized by using…”
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Modified polyethylenimines as non viral gene delivery systems for aerosol therapy: effects of nebulization on cellular uptake and transfection efficiency by Dailey, L.A., Kleemann, E., Merdan, T., Petersen, H., Schmehl, T., Gessler, T., Hänze, J., Seeger, W., Kissel, T.

“…This study examined the effect of nebulization on the cellular uptake and transfection efficiency of polyplexes from four polyethylenimine (PEI) modifications:…”
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Prospects for cationic polymers in gene and oligonucleotide therapy against cancer by Merdan, Thomas, Kopec̆ek, Jindrich, Kissel, Thomas

“…Gene and antisense/ribozyme therapy possesses tremendous potential for the successful treatment of genetically based diseases, such as cancer. Several cancer…”
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PEGylation of Poly(ethylene imine) Affects Stability of Complexes with Plasmid DNA under in Vivo Conditions in a Dose-Dependent Manner after Intravenous Injection into Mice by Merdan, Thomas, Kunath, Klaus, Petersen, Holger, Bakowsky, Udo, Voigt, Karl Heinz, Kopecek, Jindrich, Kissel, Thomas

“…The influence of PEGylation on polyplex stability from poly(ethylene imine), PEI, and plasmid DNA was investigated both in vitro and after intravenous…”
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Supramolecular Gene Delivery Vectors Showing Enhanced Transgene Expression and Good Biocompatibility by Shuai, Xintao, Merdan, Thomas, Unger, Florian, Kissel, Thomas

“…Soluble supramolecular inclusion complexes were formed by threading α-cyclodextrin (α-CD) molecules over poly(ethylene glycol) (PEG) and poly(ε-caprolactone)…”
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Integrin targeting using RGD-PEI conjugates for in vitro gene transfer by Kunath, Klaus, Merdan, Thomas, Hegener, Oliver, Häberlein, Hanns, Kissel, Thomas

“…Background Targeting to integrin receptor ανβ3 by RGD peptides seems to be a promising approach for gene delivery to proliferating endothelial cells of tumor…”
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Trastuzumab−Polyethylenimine−Polyethylene Glycol Conjugates for Targeting Her2-Expressing Tumors by Germershaus, Oliver, Merdan, Thomas, Bakowsky, Udo, Behe, Martin, Kissel, Thomas

“…In this study, we describe the synthesis and characterization of a conjugate consisting of poly(ethylene glycol 2000 Da)10-graft-poly(ethylene imine 25 kDa)…”
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Poly(ethylenimine-co-l-lactamide-co-succinamide):  A Biodegradable Polyethylenimine Derivative with an Advantageous pH-Dependent Hydrolytic Degradation for Gene Delivery by Petersen, Holger, Merdan, Thomas, Kunath, Klaus, Fischer, Dagmar, Kissel, Thomas

“…A biodegradable gene transfer vector has been synthesized by linking several low molecular weight (MW) polyethylenimine (PEI, 1200 Da) blocks using an…”
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Delivery of unmodified bioactive ribozymes by an RNA-stabilizing polyethylenimine (LMW-PEI) efficiently down-regulates gene expression by AIGNER, A, FISCHER, D, MERDAN, T, BRUS, C, KISSEL, T, CZUBAYKO, F

“…The sequence-specific cleavage of RNA molecules through ribozyme targeting is particularly attractive since it allows the effective abrogation of protein…”
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Pegylated Polyethylenimine−Fab‘ Antibody Fragment Conjugates for Targeted Gene Delivery to Human Ovarian Carcinoma Cells by Merdan, Thomas, Callahan, Jon, Petersen, Holger, Kunath, Klaus, Bakowsky, Udo, Kopečková, Pavla, Kissel, Thomas, Kopeček, Jindřich

“…Specific targeting of ovarian carcinoma cells using pegylated polyethylenimine (PEG−PEI) conjugated to the antigen binding fragment (Fab‘) of the OV-TL16…”
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Synthesis and characterization of chemically condensed oligoethylenimine containing beta-aminopropionamide linkages for siRNA delivery by Tarcha, Peter J, Pelisek, Jaroslav, Merdan, Thomas, Waters, Jan, Cheung, Kent, von Gersdorff, Katharina, Culmsee, Carsten, Wagner, Ernst

“…Abstract Polyethylenimines (PEI) are often inefficient in gene knockdown experiments with small interfering RNA (siRNA), presumably due to the strong…”
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Core-Cross-Linked Polymeric Micelles as Paclitaxel Carriers by Shuai, Xintao, Merdan, Thomas, Schaper, Andreas K, Xi, Fu, Kissel, Thomas

“…Cross-linkable di- and triblock copolymers of poly(ε-caprolactone) (PCL) and monomethoxyl poly(ethylene glycol) (MPEG) were synthesized. These amphiphilic…”
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Targeting of immunoliposomes to endothelial cells using a single-chain Fv fragment directed against human endoglin (CD105) by Völkel, Tina, Hölig, Peter, Merdan, Thomas, Müller, Rolf, Kontermann, Roland E

“…We generated immunoliposomes targeting proliferating endothelial cells by chemically coupling a single-chain Fv fragment (scFv A5) directed against human…”
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Novel Biodegradable Ternary Copolymers hy-PEI-g-PCL-b-PEG:  Synthesis, Characterization, and Potential as Efficient Nonviral Gene Delivery Vectors by Shuai, Xintao, Merdan, Thomas, Unger, Florian, Wittmar, Matthias, Kissel, Thomas

“…Diblock copolymers (MPEG-b-PCLs) of poly(ε-caprolactone) (PCL) and monomethoxyl poly(ethylene glycol) (MPEG) were synthesized by the conventional ring-opening…”
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Poly(ethylenimine-co-L-lactamide-co-succinamide): A biodegradable polyethylenimine derivative with an advantageous pH dependent hydrolytic degradation for gene delivery by PETERSEN, H, MERDAN, T, KUNATH, K, FISCHER, D, KISSEL, T

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Induction of apoptosis in murine neuroblastoma by systemic delivery of transferrin-shielded siRNA polyplexes for downregulation of Ran by Tietze, Nicole, Pelisek, Jaroslav, Philipp, Alexander, Roedl, Wolfgang, Merdan, Thomas, Tarcha, Peter, Ogris, Manfred, Wagner, Ernst

“…The polymer, OEI-HD, based on beta-propionamide-cross-linked oligoethylenimine and its chemical transferrin conjugate were evaluated for siRNA delivery into…”
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Comparison of Three Dimensional Conformal Radiation Therapy, Intensity Modulated Radiation Therapy and Volumetric Modulated Arc Therapy for Low Radiation Exposure of Normal Tissue in Patients with Prostate Cancer by Cakir, Aydin, Akgun, Zuleyha, Fayda, Merdan, Agaoglu, Fulya

“…Radiotherapy has an important role in the treatment of prostate cancer. Three-dimensional conformal radiation therapy (3D-CRT), intensity modulated radiation…”
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干旱胁迫对乌鲁木齐市常用绿化灌木光合生理特性的影响 by 买尔旦·阿不都卡德, 阿丽亚·拜都热拉, 艾力江·麦麦提, 李志元

“…S2; 以4年生乌鲁木齐市城市绿化常用5种灌木为试材,设置停灌5 d、10 d及复水3个处理,以正常灌溉为对照.测定其土壤含水量、气体交换参数和叶绿素含量等指标,研究干旱胁迫条件下5种灌木的光合特性,为耐旱园林植物的筛选提供理论依据.结果表明:随着停灌时间的延长,停灌5 d和停灌10…”
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