Search Results - "Mercer, Timothy R"

Non-coding RNAs: regulators of disease by Taft, Ryan J, Pang, Ken C, Mercer, Timothy R, Dinger, Marcel, Mattick, John S

“…For 50 years the term 'gene' has been synonymous with regions of the genome encoding mRNAs that are translated into protein. However, recent genome-wide…”
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Towards accurate and reliable resolution of structural variants for clinical diagnosis by Liu, Zhichao, Roberts, Ruth, Mercer, Timothy R, Xu, Joshua, Sedlazeck, Fritz J, Tong, Weida

“…Structural variants (SVs) are a major source of human genetic diversity and have been associated with different diseases and phenotypes. The detection of SVs…”
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Author Correction: Towards accurate and reliable resolution of structural variants for clinical diagnosis by Liu, Zhichao, Roberts, Ruth, Mercer, Timothy R., Xu, Joshua, Sedlazeck, Fritz J., Tong, Weida

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ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3 by Wei, Wei, Zhao, Qiongyi, Wang, Ziqi, Liau, Wei-Siang, Basic, Dean, Ren, Haobin, Marshall, Paul R., Zajaczkowski, Esmi L., Leighton, Laura J., Madugalle, Sachithrani U., Musgrove, Mason, Periyakaruppiah, Ambika, Shi, Jichun, Zhang, Jianjian, Mattick, John S., Mercer, Timothy R., Spitale, Robert C., Li, Xiang, Bredy, Timothy W.

“…Here, we used RNA capture-seq to identify a large population of lncRNAs that are expressed in the infralimbic prefrontal cortex of adult male mice in response…”
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RNAs as extracellular signaling molecules by Dinger, Marcel E, Mercer, Timothy R, Mattick, John S

“…RNA is emerging as a major component of the regulatory circuitry that underpins the development and physiology of complex organisms. Here we review recent…”
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Mapping of Mitochondrial RNA-Protein Interactions by Digital RNase Footprinting by Liu, Ganqiang, Mercer, Timothy R., Shearwood, Anne-Marie J., Siira, Stefan J., Hibbs, Moira E., Mattick, John S., Rackham, Oliver, Filipovska, Aleksandra

“…Human mitochondrial DNA is transcribed as long polycistronic transcripts that encompass each strand of the genome and are processed subsequently into mature…”
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Ageing-Related Changes to H3K4me3, H3K27ac, and H3K27me3 in Purified Mouse Neurons by Signal, Brandon, Phipps, Andrew J, Giles, Katherine A, Huskins, Shannon N, Mercer, Timothy R, Robinson, Mark D, Woodhouse, Adele, Taberlay, Phillippa C

“…Neurons are central to lifelong learning and memory, but ageing disrupts their morphology and function, leading to cognitive decline. Although epigenetic…”
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Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing by Gong, Binsheng, Li, Dan, Łabaj, Paweł P., Pan, Bohu, Novoradovskaya, Natalia, Thierry-Mieg, Danielle, Thierry-Mieg, Jean, Chen, Guangchun, Bergstrom Lucas, Anne, LoCoco, Jennifer S., Richmond, Todd A., Tseng, Elizabeth, Kusko, Rebecca, Happe, Scott, Mercer, Timothy R., Pabón-Peña, Carlos, Salmans, Michael, Tilgner, Hagen U., Xiao, Wenzhong, Johann, Donald J., Jones, Wendell, Tong, Weida, Mason, Christopher E., Kreil, David P., Xu, Joshua

“…Next-generation sequencing (NGS) has revolutionized genomic research by enabling high-throughput, cost-effective genome and transcriptome sequencing…”
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Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA by Willey, James C., Morrison, Tom B., Austermiller, Bradley, Crawford, Erin L., Craig, Daniel J., Blomquist, Thomas M., Jones, Wendell D., Wali, Aminah, Lococo, Jennifer S., Haseley, Nathan, Richmond, Todd A., Novoradovskaya, Natalia, Kusko, Rebecca, Chen, Guangchun, Li, Quan-Zhen, Johann, Donald J., Deveson, Ira W., Mercer, Timothy R., Wu, Leihong, Xu, Joshua

“…The primary objective of the FDA-led Sequencing and Quality Control Phase 2 (SEQC2) project is to develop standard analysis protocols and quality control…”
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The human mitochondrial transcriptome and the RNA-binding proteins that regulate its expression by Rackham, Oliver, Mercer, Timothy R., Filipovska, Aleksandra

“…The human mitochondrial transcriptome, although produced from a small and compact genome, has revealed surprising complexity in its composition and regulation…”
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A 60-GHz 144-Element Phased-Array Transceiver for Backhaul Application by Sowlati, Tirdad, Sarkar, Saikat, Perumana, Bevin George, Chan, Wei Liat, Papio Toda, Anna, Afshar, Bagher, Boers, Michael, Shin, Donghyup, Mercer, Timothy R., Chen, Wei-Hong, Grau Besoli, Alfred, Yoon, Seunghwan, Kyriazidou, Sissy, Yang, Phil, Aggarwal, Vipin, Vakilian, Nooshin, Rozenblit, Dmitriy, Kahrizi, Masoud, Zhang, Joy, Wang, Alan, Sen, Padmanava, Murphy, David, Sajjadi, Ali, Mehrabani, Alireza, Kornaros, Evangelos, Low, Khim, Kimura, Koji, Roussel, Vincent, Xie, Hongyu, Kodavati, Venkat

“…A 144-element phased array transceiver is realized using a modular tiled approach that supports 802.11ad, MCS12 single carrier 16-quadratic-amplitude…”
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Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage by Betts, Joshua A., Moradi Marjaneh, Mahdi, Al-Ejeh, Fares, Lim, Yi Chieh, Shi, Wei, Sivakumaran, Haran, Tropée, Romain, Patch, Ann-Marie, Clark, Michael B., Bartonicek, Nenad, Wiegmans, Adrian P., Hillman, Kristine M., Kaufmann, Susanne, Bain, Amanda L., Gloss, Brian S., Crawford, Joanna, Kazakoff, Stephen, Wani, Shivangi, Wen, Shu W., Day, Bryan, Möller, Andreas, Cloonan, Nicole, Pearson, John, Brown, Melissa A., Mercer, Timothy R., Waddell, Nicola, Khanna, Kum Kum, Dray, Eloise, Dinger, Marcel E., Edwards, Stacey L., French, Juliet D.

“…Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a…”
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Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans by Mattick, John S, Wong, Justin J-L, Taft, Ryan J, Nahkuri, Satu, Rasko, John EJ, Simons, Cas, Rokhsar, Daniel S, Mercer, Timothy R, Degnan, Bernard M, Korbie, Darren J, Holst, Jeff, Oey, Harald, Ritchie, William

“…Recently described tiny RNAs (tiRNAs) are derived from sequences immediately downstream of transcriptional start sites. Here a second class of nuclear ∼17–18…”
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Parallel laboratory evolution and rational debugging reveal genomic plasticity to S. cerevisiae synthetic chromosome XIV defects by Williams, Thomas C., Kroukamp, Heinrich, Xu, Xin, Wightman, Elizabeth L.I., Llorente, Briardo, Borneman, Anthony R., Carpenter, Alexander C., Van Wyk, Niel, Meier, Felix, Collier, Thomas R.V., Espinosa, Monica I., Daniel, Elizabeth L., Walker, Roy S.K., Cai, Yizhi, Nevalainen, Helena K.M., Curach, Natalie C., Deveson, Ira W., Mercer, Timothy R., Johnson, Daniel L., Mitchell, Leslie A., Bader, Joel S., Stracquadanio, Giovanni, Boeke, Jef D., Goold, Hugh D., Pretorius, Isak S., Paulsen, Ian T.

“…Synthetic chromosome engineering is a complex process due to the need to identify and repair growth defects and deal with combinatorial gene essentiality when…”
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Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus by Wu, Hui, Boackle, Susan A, Hanvivadhanakul, Punchong, Ulgiati, Daniela, Grossman, Jennifer M, Lee, Youngho, Shen, Nan, Abraham, Lawrence J, Mercer, Timothy R, Park, Elly, Hebert, Lee A, Rovin, Brad H, Birmingham, Dan J, Chang, Deh-Ming, Chen, Chung Jen, McCurdy, Deborah, Badsha, Humeira M, Thong, Bernard Y.H, Chng, Hiok H, Arnett, Frank C, Wallace, Daniel J, Yu, C. Yung, Hahn, Bevra H, Cantor, Rita M, Tsao, Betty P

“…A genomic region on distal mouse chromosome 1 and its syntenic human counterpart 1q23-42 show strong evidence of harboring lupus susceptibility genes. We found…”
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Long non-coding RNAs: definitions, functions, challenges and recommendations by Mattick, John S., Amaral, Paulo P., Carninci, Piero, Carpenter, Susan, Chang, Howard Y., Chen, Ling-Ling, Chen, Runsheng, Dean, Caroline, Dinger, Marcel E., Fitzgerald, Katherine A., Gingeras, Thomas R., Guttman, Mitchell, Hirose, Tetsuro, Huarte, Maite, Johnson, Rory, Kanduri, Chandrasekhar, Kapranov, Philipp, Lawrence, Jeanne B., Lee, Jeannie T., Mendell, Joshua T., Mercer, Timothy R., Moore, Kathryn J., Nakagawa, Shinichi, Rinn, John L., Spector, David L., Ulitsky, Igor, Wan, Yue, Wilusz, Jeremy E., Wu, Mian

“…Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes of complex organisms. The term ‘lncRNAs’ encompasses RNA polymerase I…”
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Pervasive transcription of the eukaryotic genome: functional indices and conceptual implications by Dinger, Marcel E., Amaral, Paulo P., Mercer, Timothy R., Mattick, John S.

“…Genome-wide analyses of the eukaryotic transcriptome have revealed that the majority of the genome is transcribed, producing large numbers of…”
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Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology by Deveson, Ira W., Gong, Binsheng, Lai, Kevin, LoCoco, Jennifer S., Richmond, Todd A., Schageman, Jeoffrey, Zhang, Zhihong, Novoradovskaya, Natalia, Willey, James C., Jones, Wendell, Kusko, Rebecca, Chen, Guangchun, Madala, Bindu Swapna, Blackburn, James, Stevanovski, Igor, Bhandari, Ambica, Close, Devin, Conroy, Jeffrey, Hubank, Michael, Marella, Narasimha, Mieczkowski, Piotr A., Qiu, Fujun, Sebra, Robert, Stetson, Daniel, Sun, Lihyun, Szankasi, Philippe, Tan, Haowen, Tang, Lin-ya, Arib, Hanane, Best, Hunter, Burgher, Blake, Bushel, Pierre R., Casey, Fergal, Cawley, Simon, Chang, Chia-Jung, Choi, Jonathan, Dinis, Jorge, Duncan, Daniel, Eterovic, Agda Karina, Feng, Liang, Ghosal, Abhisek, Giorda, Kristina, Glenn, Sean, Happe, Scott, Haseley, Nathan, Horvath, Kyle, Hung, Li-Yuan, Jarosz, Mirna, Kushwaha, Garima, Li, Dan, Li, Quan-Zhen, Li, Zhiguang, Liu, Liang-Chun, Liu, Zhichao, Ma, Charles, Mason, Christopher E., Megherbi, Dalila B., Morrison, Tom, Pabón-Peña, Carlos, Pirooznia, Mehdi, Proszek, Paula Z., Raymond, Amelia, Rindler, Paul, Ringler, Rebecca, Scherer, Andreas, Shaknovich, Rita, Shi, Tieliu, Smith, Melissa, Song, Ping, Strahl, Maya, Thodima, Venkat J., Tom, Nikola, Verma, Suman, Wang, Jiashi, Wu, Leihong, Xiao, Wenzhong, Xu, Chang, Yang, Mary, Zhang, Guangliang, Zhang, Sa, Zhang, Yilin, Shi, Leming, Tong, Weida, Johann, Donald J., Mercer, Timothy R., Xu, Joshua

“…Circulating tumor DNA (ctDNA) sequencing is being rapidly adopted in precision oncology, but the accuracy, sensitivity and reproducibility of ctDNA assays is…”
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Non-coding RNAs: regulators of disease: Genes, Genomes and Disease by TAFT, Ryan J, PANG, Ken C, MERCER, Timothy R, DINGER, Marcel, MATTICK, John S

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