Search Results - "Mercer, Susan L."

Opioid analgesics and P-glycoprotein efflux transporters: a potential systems-level contribution to analgesic tolerance by Mercer, Susan L, Coop, Andrew

“…Chronic clinical pain remains poorly treated. Despite attempts to develop novel analgesic agents, opioids remain the standard analgesics of choice in the…”
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DARK Classics in Chemical Neuroscience: Morphine by Devereaux, Andrea L, Mercer, Susan L, Cunningham, Christopher W

“…As the major psychoactive agent in opium and direct precursor for heroin, morphine is a historically critical molecule in chemical neuroscience. A structurally…”
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DARK Classics in Chemical Neuroscience: Fentanyl by Burns, S. Mallory, Cunningham, Christopher W, Mercer, Susan L

“…Fentanyl rose to prominence as an alternative analgesic to morphine nearly 50 years ago; today, fentanyl has re-emerged as a dangerous recreational substance…”
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Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβ by Smith, Nicholas A, Byl, Jo Ann W, Mercer, Susan L, Deweese, Joseph E, Osheroff, Neil

“…Etoposide is a topoisomerase II poison that is utilized to treat a broad spectrum of human cancers. Despite its wide clinical use, 2–3% of patients treated…”
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Two-Mechanism Model for the Interaction of Etoposide Quinone with Topoisomerase IIα by Gibson, Elizabeth G, King, McKenzie M, Mercer, Susan L, Deweese, Joseph E

“…Topoisomerase II is an essential nuclear enzyme involved in regulating DNA topology to facilitate replication and cell division. Disruption of topoisomerase II…”
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Opioids and efflux transporters. Part 3: P-glycoprotein substrate activity of 3-hydroxyl addition to meperidine analogs by Mercer, Susan L., Cunningham, Christopher W., Eddington, Natalie D., Coop, Andrew

“…Numerous studies have shown that many clinically employed opioid analgesics are substrates for P-glycoprotein (P-gp), suggesting that up-regulation of P-gp may…”
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Impact of cytochrome P450 variation on meperidine N-demethylation to the neurotoxic metabolite normeperidine by Murray, Jessica L., Mercer, Susan L., Jackson, Klarissa D.

“…1. Meperidine is an opioid analgesic that undergoes N-demethylation to form the neurotoxic metabolite normeperidine. Previous studies indicate that meperidine…”
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HU-331 Is a Catalytic Inhibitor of Topoisomerase IIα by Regal, Kellie M, Mercer, Susan L, Deweese, Joseph E

“…Topoisomerases are essential enzymes that are involved in DNA metabolism. Topoisomerase II generates transient DNA strand breaks that are stabilized by…”
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Synthesis and evaluation of etoposide and podophyllotoxin analogs against topoisomerase IIα and HCT-116 cells by Murphy, Matthew B., Kumar, Priyanka, Bradley, Amber M., Barton, Christopher E., Deweese, Joseph E., Mercer, Susan L.

“…[Display omitted] •Analogs 2’,6’-dichloropodophyllotoxin (8), 2’-chloroetoposide (9) and 2’-chloro-4’-demethylepipodophyllotoxin (10) displayed variable…”
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HU-331 and Oxidized Cannabidiol Act as Inhibitors of Human Topoisomerase IIα and β by Wilson, James T, Fief, Cole A, Jackson, Klarissa D, Mercer, Susan L, Deweese, Joseph E

“…Topoisomerase II is a critical enzyme in replication, transcription, and the regulation of chromatin topology. Several anticancer agents target topoisomerases…”
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Etoposide Quinone Is a Redox-Dependent Topoisomerase II Poison by Jacob, David A, Mercer, Susan L, Osheroff, Neil, Deweese, Joseph E

“…Etoposide is a topoisomerase II poison that is used to treat a variety of human cancers. Unfortunately, 2–3% of patients treated with etoposide develop…”
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Catalytic Core of Human Topoisomerase IIα: Insights into Enzyme–DNA Interactions and Drug Mechanism by Lindsey, R. Hunter, Pendleton, MaryJean, Ashley, Rachel E, Mercer, Susan L, Deweese, Joseph E, Osheroff, Neil

“…Coordination between the N-terminal gate and the catalytic core of topoisomerase II allows the proper capture, cleavage, and transport of DNA during the…”
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ACS Chemical Neuroscience Molecule Spotlight on Contrave by Mercer, Susan L

“…Contrave is an investigational fixed-dose combination drug of naltrexone and bupropion currently in Phase III clinical trials for the treatment of obesity…”
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Etoposide Catechol Is an Oxidizable Topoisomerase II Poison by Jacob, David A, Gibson, Elizabeth G, Mercer, Susan L, Deweese, Joseph E

“…Topoisomerase II regulates DNA topology by generating transient double-stranded breaks. The anticancer drug etoposide targets topoisomerase II and is…”
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Drugs of Abuse and Addiction: An integrated approach to teaching by Miller, Lindsey N., Mercer, Susan L.

“…To describe the design, implementation, and student perceptions of a Drugs of Abuse and Addiction elective course utilizing an integrated teaching model…”
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Opioids and efflux transporters. Part 4: influence of N-substitution on P-glycoprotein substrate activity of noroxymorphone analogues by Metcalf, Matthew D, Rosicky, Andrew D, Hassan, Hazem E, Eddington, Natalie D, Coop, Andrew, Cunningham, Christopher W, Mercer, Susan L

“…The efflux transporter protein P-glycoprotein (P-gp) is capable of affecting the central distribution of diverse neurotherapeutics, including opioid…”
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Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348) by Koek, Wouter, Mercer, Susan L, Coop, Andrew, France, Charles P

“…Gamma-hydroxybutyrate (GHB) is used therapeutically and recreationally. The mechanism by which GHB produces its therapeutic and recreational effects is not…”
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ACS Chemical Neuroscience Molecule Spotlight on Qnexa by Mercer, Susan L

“…Qnexa (VI-0521) is an investigational fixed-dose combination drug of phentermine and topiramate currently in Phase III clinical trials for the treatment of…”
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Evaluation of the P-glycoprotein (Abcb1) affinity status of a series of morphine analogs: Comparative study with meperidine analogs to identify opioids with minimal P-glycoprotein interactions by Hassan, Hazem E., Mercer, Susan L., Cunningham, Christopher W., Coop, Andrew, Eddington, Natalie D.

“…One of the major shortcomings of many commonly used opioids is the fact that they are P-gp substrates, which represents a major obstacle towards effective pain…”
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Cataleptic effects of γ-hydroxybutyrate (GHB), its precursor γ-butyrolactone (GBL), and GABAB receptor agonists in mice : differential antagonism by the GABAB receptor antagonist CGP35348 by KOEK, Wouter, MERCER, Susan L, COOP, Andrew

“…Gamma-hydroxybutyrate (GHB) is used to treat narcolepsy but is also abused. GHB has many actions in common with the GABA(B) receptor agonist baclofen. To…”
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