Search Results - "Mercedes Marín-Aguilera"

Circulating tumor DNA reveals complex biological features with clinical relevance in metastatic breast cancer by Prat, Aleix, Brasó-Maristany, Fara, Martínez-Sáez, Olga, Sanfeliu, Esther, Xia, Youli, Bellet, Meritxell, Galván, Patricia, Martínez, Débora, Pascual, Tomás, Marín-Aguilera, Mercedes, Rodríguez, Anna, Chic, Nuria, Adamo, Barbara, Paré, Laia, Vidal, Maria, Margelí, Mireia, Ballana, Ester, Gómez-Rey, Marina, Oliveira, Mafalda, Felip, Eudald, Matito, Judit, Sánchez-Bayona, Rodrigo, Suñol, Anna, Saura, Cristina, Ciruelos, Eva, Tolosa, Pablo, Muñoz, Montserrat, González-Farré, Blanca, Villagrasa, Patricia, Parker, Joel S., Perou, Charles M., Vivancos, Ana

“…Liquid biopsy has proven valuable in identifying individual genetic alterations; however, the ability of plasma ctDNA to capture complex tumor phenotypes with…”
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Nuclear IGF-1R predicts chemotherapy and targeted therapy resistance in metastatic colorectal cancer by Codony-Servat, Jordi, Cuatrecasas, Miriam, Asensio, Elena, Montironi, Carla, Martínez-Cardús, Anna, Marín-Aguilera, Mercedes, Horndler, Carlos, Martínez-Balibrea, Eva, Rubini, Michele, Jares, Pedro, Reig, Oscar, Victoria, Iván, Gaba, Lydia, Martín-Richard, Marta, Alonso, Vicente, Escudero, Pilar, Fernández-Martos, Carlos, Feliu, Jaime, Méndez, Jose Carlos, Méndez, Miguel, Gallego, Javier, Salud, Antonieta, Rojo, Federico, Castells, Antoni, Prat, Aleix, Rosell, Rafael, García-Albéniz, Xabier, Camps, Jordi, Maurel, Joan

“…Background: Although chemotherapy is the cornerstone treatment for patients with metastatic colorectal cancer (mCRC), acquired chemoresistance is common and…”
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Development and validation of the new HER2DX assay for predicting pathological response and survival outcome in early-stage HER2-positive breast cancer by Prat, Aleix, Guarneri, Valentina, Pascual, Tomás, Brasó-Maristany, Fara, Sanfeliu, Esther, Paré, Laia, Schettini, Francesco, Martínez, Débora, Jares, Pedro, Griguolo, Gaia, Dieci, Maria Vittoria, Cortés, Javier, Llombart-Cussac, Antonio, Conte, Benedetta, Marín-Aguilera, Mercedes, Chic, Nuria, Puig-Butillé, Joan Anton, Martínez, Antonio, Galván, Patricia, Tsai, Yi-Hsuan, González-Farré, Blanca, Mira, Aurea, Vivancos, Ana, Villagrasa, Patricia, Parker, Joel S., Conte, Pierfranco, Perou, Charles M.

“…Both clinical and genomic data independently predict survival and treatment response in early-stage HER2-positive breast cancer. Here we present the…”
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SPARC mediates metastatic cooperation between CSC and non-CSC prostate cancer cell subpopulations by Mateo, Francesca, Meca-Cortés, Oscar, Celià-Terrassa, Toni, Fernández, Yolanda, Abasolo, Ibane, Sánchez-Cid, Lourdes, Bermudo, Raquel, Sagasta, Amaia, Rodríguez-Carunchio, Leonardo, Pons, Mònica, Cánovas, Verónica, Marín-Aguilera, Mercedes, Mengual, Lourdes, Alcaraz, Antonio, Schwartz, Jr, Simó, Mellado, Begoña, Aguilera, Kristina Y, Brekken, Rolf, Fernández, Pedro L, Paciucci, Rosanna, Thomson, Timothy M

“…Tumor cell subpopulations can either compete with each other for nutrients and physical space within the tumor niche, or co-operate for enhanced survival, or…”
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Safety, activity, and molecular heterogeneity following neoadjuvant non-pegylated liposomal doxorubicin, paclitaxel, trastuzumab, and pertuzumab in HER2-positive breast cancer (Opti-HER HEART): an open-label, single-group, multicenter, phase 2 trial by Gavilá, Joaquín, Oliveira, Mafalda, Pascual, Tomás, Perez-Garcia, Jose, Gonzàlez, Xavier, Canes, Jordi, Paré, Laia, Calvo, Isabel, Ciruelos, Eva, Muñoz, Montserrat, Virizuela, Juan A, Ruiz, Isabel, Andrés, Raquel, Perelló, Antonia, Martínez, Jerónimo, Morales, Serafín, Marín-Aguilera, Mercedes, Martínez, Débora, Quero, Juan C, Llombart-Cussac, Antonio, Prat, Aleix

“…Keywords: Breast cancer, PAM50, HER2, intrinsic subtypes, cardiac safety, HER2-enriched, neoadjuvant…”
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Cell Plasticity-Related Phenotypes and Taxanes Resistance in Castration-Resistant Prostate Cancer by Jiménez, Natalia, Reig, Òscar, Montalbo, Ruth, Milà-Guasch, Maria, Nadal-Dieste, Lluis, Castellano, Giancarlo, Lozano, Juan José, Victoria, Iván, Font, Albert, Rodriguez-Vida, Alejo, Carles, Joan, Suárez, Cristina, Domènech, Montserrat, Sala-González, Núria, Fernández, Pedro Luis, Rodríguez-Carunchio, Leonardo, Díaz, Sherley, Prat, Aleix, Marín-Aguilera, Mercedes, Mellado, Begoña

“…The prostatic tumor cells plasticity is involved in resistance to hormone-therapy, allowing these cells to survive despite androgen receptor inhibition…”
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Biomarkers vs conventional histological analysis to detect lymph node micrometastases in bladder cancer: a real improvement? by Gazquez, Cristina, Ribal, Maria José, Marín‐Aguilera, Mercedes, Kayed, Hany, Fernández, Pedro Luís, Mengual, Lourdes, Alcaraz, Antonio

“…Study Type – Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Muscle invasive bladder cancer has a mortality…”
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Multiplex preamplification of specific cDNA targets prior to gene expression analysis by TaqMan Arrays by Mengual, Lourdes, Burset, Moisès, Marín-Aguilera, Mercedes, Ribal, María José, Alcaraz, Antonio

“…An accurate gene expression quantification using TaqMan Arrays (TA) could be limited by the low RNA quantity obtained from some clinical samples. The novel…”
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Epithelial-to-mesenchymal transition mediates docetaxel resistance and high risk of relapse in prostate cancer by Marín-Aguilera, Mercedes, Codony-Servat, Jordi, Reig, Òscar, Lozano, Juan José, Fernández, Pedro Luis, Pereira, María Verónica, Jiménez, Natalia, Donovan, Michael, Puig, Pere, Mengual, Lourdes, Bermudo, Raquel, Font, Albert, Gallardo, Enrique, Ribal, María José, Alcaraz, Antonio, Gascón, Pere, Mellado, Begoña

“…Molecular characterization of radical prostatectomy specimens after systemic therapy may identify a gene expression profile for resistance to therapy. This…”
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The influence of treatment sequence in the prognostic value of TMPRSS2‐ERG as biomarker of taxane resistance in castration‐resistant prostate cancer by Marín‐Aguilera, Mercedes, Reig, Òscar, Milà‐Guasch, Maria, Font, Albert, Domènech, Montserrat, Rodríguez‐Vida, Alejo, Carles, Joan, Suárez, Cristina, Alba, Aránzazu González, Jiménez, Natalia, Victoria, Iván, Sala‐González, Núria, Ribal, Maria José, López, Sandra, Etxaniz, Olatz, Anguera, Geòrgia, Maroto, Pablo, Fernández, Pedro Luis, Prat, Aleix, Mellado, Begoña

“…TMPRSS2‐ERG expression in blood has been correlated with low docetaxel benefit in metastatic castration‐resistant prostate cancer (mCRPC). This multicenter…”
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Identification of docetaxel resistance genes in castration-resistant prostate cancer by Marín-Aguilera, Mercedes, Codony-Servat, Jordi, Kalko, Susana G, Fernández, Pedro L, Bermudo, Raquel, Buxo, Elvira, Ribal, María José, Gascón, Pedro, Mellado, Begoña

“…Docetaxel-based chemotherapy is the standard first-line therapy in metastatic castration-resistant prostate cancer (CRPC). However, most patients eventually…”
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The Transmodulation of HER2 and EGFR by Substance P in Breast Cancer Cells Requires c-Src and Metalloproteinase Activation by Garcia-Recio, Susana, Pastor-Arroyo, Eva M, Marín-Aguilera, Mercedes, Almendro, Vanessa, Gascón, Pedro

“…Substance P (SP) is a pleiotropic cytokine/neuropeptide that enhances breast cancer (BC) aggressiveness by transactivating tyrosine kinase receptors like EGFR…”
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Nuclear factor-kappa B and interleukin-6 related docetaxel resistance in castration-resistant prostate cancer by Codony-Servat, Jordi, Marín-Aguilera, Mercedes, Visa, Laura, García-Albéniz, Xabier, Pineda, Estela, Fernández, Pedro L., Filella, Xavier, Gascón, Pere, Mellado, Begoña

“…BACKGROUND Previous work showed that the NF‐κB survival pathway is activated by docetaxel (D) and contributes to D resistance in prostate cancer. In this study…”
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Assessment of a Genomic Assay in Patients With ERBB2-Positive Breast Cancer Following Neoadjuvant Trastuzumab-Based Chemotherapy With or Without Pertuzumab by Bueno-Muiño, Coralia, Echavarría, Isabel, López-Tarruella, Sara, Roche-Molina, Marta, Del Monte-Millán, María, Massarrah, Tatiana, Jerez, Yolanda, Ayala de la Peña, Francisco, García-Sáenz, José Ángel, Moreno, Fernando, Rodríguez-Lescure, Álvaro, Malón-Giménez, Diego, Ballesteros García, Ana Isabel, Marín-Aguilera, Mercedes, Galván, Patricia, Brasó-Maristany, Fara, Waks, Adrienne G, Tolaney, Sara M, Mittendorf, Elizabeth A, Vivancos, Ana, Villagrasa, Patricia, Parker, Joel S, Perou, Charles M, Paré, Laia, Villacampa, Guillermo, Prat, Aleix, Martín, Miguel

“…Biomarkers to guide the use of pertuzumab in the treatment of early-stage ERBB2 (formerly HER2)-positive breast cancer beyond simple ERBB2 status are needed…”
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Dual inhibition of MEK and PI3Kβ/δ-a potential therapeutic strategy in PTEN-wild-type docetaxel-resistant metastatic prostate cancer by Ruiz de Porras, Vicenç, Bernat-Peguera, Adrià, Alcon, Clara, Laguia, Fernando, Fernández-Saorin, Maria, Jiménez, Natalia, Senan-Salinas, Ana, Solé-Blanch, Carme, Feu, Andrea, Marín-Aguilera, Mercedes, Pardo, Juan Carlos, Ochoa-de-Olza, Maria, Montero, Joan, Mellado, Begoña, Font, Albert

“…Docetaxel remains the standard treatment for metastatic castration-resistant prostate cancer (mCRPC). However, resistance frequently emerges as a result of…”
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Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer by Marín-Aguilera, Mercedes, Reig, Òscar, Lozano, Juan José, Jiménez, Natalia, García-Recio, Susana, Erill, Nadina, Gaba, Lydia, Tagliapietra, Andrea, Ortega, Vanesa, Carrera, Gemma, Colomer, Anna, Gascón, Pedro, Mellado, Begoña

“…The enumeration of circulating tumor cells (CTCs) in peripheral blood correlates with clinical outcome in castration-resistant prostate cancer (CRPC). We…”
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Androgen Receptor and Its Splicing Variant 7 Expression in Peripheral Blood Mononuclear Cells and in Circulating Tumor Cells in Metastatic Castration-Resistant Prostate Cancer by Marín-Aguilera, Mercedes, Jiménez, Natalia, Reig, Òscar, Montalbo, Ruth, Verma, Ajit K, Castellano, Giancarlo, Mengual, Lourdes, Victoria, Iván, Pereira, María V, Milà-Guasch, Maria, García-Recio, Susana, Benítez-Ribas, Daniel, Cabezón, Raquel, González, Azucena, Juan, Manel, Prat, Aleix, Mellado, Begoña

“…Androgen receptor (AR) signaling remains crucial in castration-resistant prostate cancer (CRPC). Since it is also essential in immune cells, we studied whether…”
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Utility of Urothelial mRNA Markers in Blood for Staging and Monitoring Bladder Cancer by Marín-Aguilera, Mercedes, Mengual, Lourdes, Ribal, María José, Ars, Elisabet, Ríos, José, Gázquez, Cristina, Villavicencio, Humberto, Alcaraz, Antonio

“…Objective To test the efficiency of 6 mRNA bladder markers in staging urothelial cell carcinoma (UCC) and monitoring UCC dissemination from blood samples…”
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Molecular Lymph Node Staging in Bladder Urothelial Carcinoma: Impact on Survival by Marín-Aguilera, Mercedes, Mengual, Lourdes, Burset, Moisès, Oliver, Artur, Ars, Elisabet, Ribal, María José, Colomer, Dolors, Mellado, Begoña, Villavicencio, Humberto, Algaba, Ferran, Alcaraz, Antonio

“…Abstract Background Routine histologic analysis of lymph nodes (LN) for detecting disseminated bladder urothelial carcinoma (BUC) lacks sensitivity. Objective…”
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TMPRSS2-ERG in Blood and Docetaxel Resistance in Metastatic Castration-resistant Prostate Cancer by Reig, Òscar, Marín-Aguilera, Mercedes, Carrera, Gemma, Jiménez, Natalia, Paré, Laia, García-Recio, Susana, Gaba, Lydia, Pereira, Maria Verónica, Fernández, Pedro, Prat, Aleix, Mellado, Begoña

“…Abstract TMPRSS2-ERG rearrangement is a genetic alteration exclusive to prostate cancer, associated with taxane resistance in preclinical models. Its detection…”
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