Radiosterilization of sulfonamides: I: determination of the effects of gamma irradiation on solid sulfonamides

Radiosterilization of sulfonamides: I: determination of the effects of gamma irradiation on solid sulfonamides

Three antibiotics sulfafurazole (SFZ), sulfamethoxazole (SMZ) and sulfacetamide sodium (SSA-Na) belonging to sulfonamides were irradiated and changes in physico-chemical properties, pH, melting points, UV, IR, NMR, TLC, GC-MS, ESR characteristics, antimicrobial activities of active components were s...

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Bibliographic Details
Published in:Radiation physics and chemistry (Oxford, England : 1993) Vol. 69; no. 6; pp. 511 - 520
Main Authors: Mercanoğlu, G.Olguner, Özer, A.Y, Çolak, Ş, Korkmaz, M, Özalp, M, Ekizoğlu, M, Barbarin, N, Tilquin, B
Format: Journal Article
Language:English
Published: Elsevier Ltd 01-04-2004
Subjects:
ESR
GC-MS
Sterilization
Sulfacetamide sodium
Sulfafurazole
Sulfamethoxazole
GC-MS
Sulfafurazole
Sulfacetamide sodium
Sulfamethoxazole
ESR
Sterilization
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Summary:Three antibiotics sulfafurazole (SFZ), sulfamethoxazole (SMZ) and sulfacetamide sodium (SSA-Na) belonging to sulfonamides were irradiated and changes in physico-chemical properties, pH, melting points, UV, IR, NMR, TLC, GC-MS, ESR characteristics, antimicrobial activities of active components were studied at normal and accelerated stability test conditions. Two radiolytic intermediates for both SFZ and SMZ and four radiolytic intermediates for SSA-Na were found in the irradiated solid samples after the GC-MS analysis. The results obtained under normal and accelerated stability test conditions were observed to be consistent with the unirradiated values.
ISSN:0969-806X
1879-0895
DOI:10.1016/j.radphyschem.2003.09.005