Search Results - "Meotti, C."

Intra-dimer cooperativity between the active site cysteines during the oxidation of peroxiredoxin 2 by Peskin, Alexander V., Meotti, Flávia C., de Souza, Luiz F., Anderson, Robert F., Winterbourn, Christine C., Salvador, Armindo

“…Peroxiredoxin 2 (Prdx2) and other typical 2-Cys Prdxs function as homodimers in which hydrogen peroxide oxidizes each active site cysteine to a sulfenic acid…”
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Heat shock protein B1 is a key mediator of prolactin-induced beta-cell cytoprotection against oxidative stress by Terra, Letícia F., Wailemann, Rosangela A.M., dos Santos, Ancély F., Gomes, Vinicius M., Silva, Railmara P., Laporte, Anna, Meotti, Flávia C., Terra, Walter R., Palmisano, Giuseppe, Lortz, Stephan, Labriola, Leticia

“…Maintaining islet cell viability in vitro, although challenging, appears to be a strategy for improving the outcome of pancreatic islet transplantation. We…”
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Identification of tyrosine brominated extracellular matrix proteins in normal and fibrotic lung tissues by Cruz, Litiele Cezar, Habibovic, Aida, Dempsey, Bianca, Massafera, Mariana P., Janssen-Heininger, Yvonne M.W., Lin, Miao-chong Joy, Hoffman, Evan T., Weiss, Daniel J., Huang, Steven K., van der Vliet, Albert, Meotti, Flavia C.

“…Peroxidasin (PXDN) is a secreted heme peroxidase that catalyzes the oxidative crosslinking of collagen IV within the extracellular matrix (ECM) via…”
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Peroxiredoxin expression and redox status in neutrophils and HL-60 cells by de Souza, Luiz F., Pearson, Andree G., Pace, Paul E., Dafre, Alcir L., Hampton, Mark B., Meotti, Flávia C., Winterbourn, Christine C.

“…Peroxiredoxins (Prxs) are thiol peroxidases with a key role in antioxidant defense and redox signaling. They could be important in neutrophils for handling the…”
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Inflammatory muscle pain is dependent on the activation of kinin B1 and B2 receptors and intracellular kinase pathways by Meotti, FC, Campos, R, da Silva, KABS, Paszcuk, AF, Costa, R, Calixto, JB

“…BACKGROUND AND PURPOSE B1 and B2 kinin receptors are involved in pain transmission but they may have different roles in the muscle pain induced by intense…”
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Uric acid disrupts hypochlorous acid production and the bactericidal activity of HL-60 cells by Carvalho, Larissa A.C., Lopes, João P.P.B., Kaihami, Gilberto H., Silva, Railmara P., Bruni-Cardoso, Alexandre, Baldini, Regina L., Meotti, Flavia C.

“…Uric acid is the end product of purine metabolism in humans and is an alternative physiological substrate for myeloperoxidase. Oxidation of uric acid by this…”
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Antagonism of the transient receptor potential ankyrin 1 (TRPA1) attenuates hyperalgesia and urinary bladder overactivity in cyclophosphamide-induced haemorrhagic cystitis by Meotti, Flavia C., Forner, Stefânia, Lima-Garcia, Juliana F., Viana, Alice F., Calixto, João B.

“…•Cyclophosphamide caused bladder overactivity in rats.•The urotoxic effects were associated to a nociceptive behavior.•Overactivity and nociception were…”
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Cerebellar thiol status and motor deficit after lactational exposure to methylmercury by Franco, Jeferson L., Teixeira, Adriana, Meotti, Flávia C., Ribas, Camila M., Stringari, James, Garcia Pomblum, Solange C., Moro, Ângela M., Bohrer, Denise, Bairros, André V., Dafre, Alcir L., Santos, Adair R.S., Farina, Marcelo

“…This study examined the exclusive contribution of methylmercury (MeHg) exposure through maternal milk on biochemical parameters related to the thiol status…”
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Protective role of aryl and alkyl diselenides on lipid peroxidation by Meotti, F.C, Stangherlin, E.C, Zeni, G, Nogueira, C.W, Rocha, J.B.T

“…The concept that selenium-containing molecules may be better nucleophiles (and therefore antioxidants) than classical antioxidants has led to the design of…”
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Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice by Meotti, F.C., Borges, V.C., Zeni, G., Rocha, J.B.T., Nogueira, C.W.

“…The occupational importance of tellurium and selenium is growing rapidly, but the biochemistry of exposure is poorly understood. Here we report the potential…”
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Investigations into the potential neurotoxicity induced by diselenides in mice and rats by Nogueira, C.W, Meotti, F.C, Curte, E, Pilissão, C, Zeni, G, Rocha, J.B.T

“…It is well known that selenium is highly toxic to several species of mammals. Here we report the potential neurotoxicity of diselenides, as measured by the…”
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Allantoin as an independent marker associated with carotid intima-media thickness in subclinical atherosclerosis by Santana, M S, Nascimento, K P, Lotufo, P A, Benseãor, I M, Meotti, F C

“…Allantoin is the main product of uric acid oxidation and was found to be augmented in atherosclerotic plaque in human autopsy and in animal models of…”
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The selective and competitive N-methyl-D-aspartate receptor antagonist, (−)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid, prevents synaptic toxicity induced by amyloid-β in mice by Bicca, M.A, Figueiredo, C.P, Piermartiri, T.C, Meotti, F.C, Bouzon, Z.L, Tasca, C.I, Medeiros, R, Calixto, J.B

“…Abstract The toxicity of amyloid β (Aβ) is highly associated with Alzheimer's disease (AD), which has a high incidence in elderly people worldwide. While the…”
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The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling by Russo, Lilian Cristina, Tomasin, Rebeka, Matos, Isaac Araújo, Manucci, Antonio Carlos, Sowa, Sven T., Dale, Katie, Caldecott, Keith W., Lehtiö, Lari, Schechtman, Deborah, Meotti, Flavia C., Bruni-Cardoso, Alexandre, Hoch, Nicolas Carlos

“…SARS-CoV-2 nonstructural protein 3 (Nsp3) contains a macrodomain that is essential for coronavirus pathogenesis and is thus an attractive target for drug…”
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Postnatal methylmercury exposure induces hyperlocomotor activity and cerebellar oxidative stress in mice: dependence on the neurodevelopmental period by Stringari, James, Meotti, Flávia C, Souza, Diogo O, Santos, Adair R S, Farina, Marcelo

“…During the early postnatal period the central nervous system (CNS) is extremely sensitive to external agents. The present study aims at the investigation of…”
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TRPA1 antagonists as potential analgesic drugs by Andrade, E L, Meotti, F C, Calixto, J B

“…The necessity of safe and effective treatments for chronic pain has intensified the search for new analgesic drugs. In the last few years, members of a…”
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Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2 by Carvalho, Larissa A.C., Truzzi, Daniela R., Fallani, Thamiris S., Alves, Simone V., Toledo, José Carlos, Augusto, Ohara, Netto, Luís E.S., Meotti, Flavia C.

“…Urate hydroperoxide is a product of the oxidation of uric acid by inflammatory heme peroxidases. The formation of urate hydroperoxide might be a key event in…”
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Targeting Myeloperoxidase Ameliorates Gouty Arthritis: A Virtual Screening Success Story by Matos, Isaac de A., Dallazen, Jorge L., Reis, Lorenna R., Souza, Luiz Felipe, Bevevino, Regina C., de Moura, Rafael D., Ronsein, Graziella E., Hoch, Nicolas Carlos, da Costa Júnior, Nivan Bezerra, Costa, Soraia Kátia P., Meotti, Flavia C.

“…This study presents a new approach for identifying myeloperoxidase (MPO) inhibitors with strong in vivo efficacy. By combining inhibitor-like rules and…”
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Different patterns of dermatological presentations in patients co-infected with human immunodeficiency virus and hepatitis C virus (HCV), and those infected with HCV alone by Cunha, V. S., Meotti, C., Oliveira, J. H., Sprinz, E., Álvares-da-Silva, M. R., Goldani, L. Z.

“…Summary Background.  Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) share the same transmission routes. About 30% of HIV‐positive patients are…”
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Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2 by Peskin, Alexander V., Meotti, Flavia C., Kean, Kelsey M., Göbl, Christoph, Peixoto, Albert Souza, Pace, Paul E., Horne, Christopher R., Heath, Sarah G., Crowther, Jennifer M., Dobson, Renwick C.J., Karplus, P. Andrew, Winterbourn, Christine C.

“…Peroxiredoxin 2 (Prdx2) is a thiol peroxidase with an active site Cys (C52) that reacts rapidly with H2O2 and other peroxides. The sulfenic acid product…”
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