Search Results - "Menzies, Sam A."

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1 by Menzies, Sam A, Volkmar, Norbert, van den Boomen, Dick Jh, Timms, Richard T, Dickson, Anna S, Nathan, James A, Lehner, Paul J

“…Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is…”
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Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens by Timms, Richard T., Menzies, Sam A., Tchasovnikarova, Iva A., Christensen, Lea C., Williamson, James C., Antrobus, Robin, Dougan, Gordon, Ellgaard, Lars, Lehner, Paul J.

“…The application of forward genetic screens to cultured human cells represents a powerful method to study gene function. The repurposing of the bacterial…”
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A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface by Stewart, Sarah E, Menzies, Sam A, Popa, Stephanie J, Savinykh, Natalia, Petrunkina Harrison, Anna, Lehner, Paul J, Moreau, Kevin

“…Galectins are a family of lectin binding proteins expressed both intracellularly and extracellularly. Galectin-3 (Gal-3, also known as LGALS3) is expressed at…”
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A genome-wide CRISPR screen identifies regulation factors of the TLR3 signalling pathway by Zablocki-Thomas, Laurent, Menzies, Sam A, Lehner, Paul J, Manel, Nicolas, Benaroch, Philippe

“…A subset of TLRs is specialised in the detection of incoming pathogens by sampling endosomes for nucleic acid contents. Among them, TLR3 senses the abnormal…”
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Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing by Li, Ji, Stagg, Nicola J., Johnston, Jennifer, Harris, Michael J., Menzies, Sam A., DiCara, Danielle, Clark, Vanessa, Hristopoulos, Maria, Cook, Ryan, Slaga, Dionysos, Nakamura, Rin, McCarty, Luke, Sukumaran, Siddharth, Luis, Elizabeth, Ye, Zhengmao, Wu, Thomas D., Sumiyoshi, Teiko, Danilenko, Dimitry, Lee, Genee Y., Totpal, Klara, Ellerman, Diego, Hötzel, Isidro, James, John R., Junttila, Teemu T.

“…The anti-FcRH5/CD3 T cell-dependent bispecific antibody (TDB) targets the B cell lineage marker FcRH5 expressed in multiple myeloma (MM) tumor cells. We…”
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