Search Results - "Menyhart, Otília"

Correction: MultipleTesting.com: A tool for life science researchers for multiple hypothesis testing correction by Menyhart, Otília, Weltz, Boglárka, Gyorffy, Balázs

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Uncovering Potential Therapeutic Targets in Colorectal Cancer by Deciphering Mutational Status and Expression of Druggable Oncogenes by Menyhart, Otília, Kakisaka, Tatsuhiko, Pongor, Lőrinc Sándor, Uetake, Hiroyuki, Goel, Ajay, Győrffy, Balázs

“…Numerous driver mutations have been identified in colorectal cancer (CRC), but their relevance to the development of targeted therapies remains elusive. The…”
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Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets by Nagy, Ádám, Lánczky, András, Menyhárt, Otília, Győrffy, Balázs

“…Multiple studies suggested using different miRNAs as biomarkers for prognosis of hepatocellular carcinoma (HCC). We aimed to assemble a miRNA expression…”
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Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma by Menyhárt, Otília, Nagy, Ádám, Győrffy, Balázs

“…Potential prognostic biomarker candidates for hepatocellular carcinoma (HCC) are abundant, but their generalizability is unexplored. We cross-validated markers…”
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MultipleTesting.com: A tool for life science researchers for multiple hypothesis testing correction by Menyhart, Otília, Weltz, Boglárka, Gyorffy, Balázs

“…Scientists from nearly all disciplines face the problem of simultaneously evaluating many hypotheses. Conducting multiple comparisons increases the likelihood…”
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Multi-omics approaches in cancer research with applications in tumor subtyping, prognosis, and diagnosis by Menyhárt, Otília, Győrffy, Balázs

“…•Single-level data analysis produced by high-throughput technologies is limited by showing only a narrow window of cellular functions.•Data integration across…”
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Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches by Menyhárt, Otília, Gyorffy, Balázs

“…Medulloblastoma (MB) is the most common malignant childhood tumor of the brain. Multimodal treatment consisting of surgery, radiation therapy, and chemotherapy…”
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Dietary approaches for exploiting metabolic vulnerabilities in cancer by Menyhárt, Otília, Győrffy, Balázs

“…Renewed interest in tumor metabolism sparked an enthusiasm for dietary interventions to prevent and treat cancer. Changes in diet impact circulating nutrient…”
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Guidelines for the selection of functional assays to evaluate the hallmarks of cancer by Menyhárt, Otília, Harami-Papp, Hajnalka, Sukumar, Saraswati, Schäfer, Reinhold, Magnani, Luca, de Barrios, Oriol, Győrffy, Balázs

“…The hallmarks of cancer capture the most essential phenotypic characteristics of malignant transformation and progression. Although numerous factors involved…”
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A Comprehensive Outline of Trastuzumab Resistance Biomarkers in HER2 Overexpressing Breast Cancer by Menyhárt, Otília, Santarpia, Libero, Győrffy, Balázs

“…The introduction of trastuzumab for anti-HER2 therapy dramatically changed the clinical outcome for HER2 (ERBB2, neu) positive breast cancer patients. Today,…”
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Gene expression-based biomarkers designating glioblastomas resistant to multiple treatment strategies by Menyhárt, Otília, Fekete, János Tibor, Győrffy, Balázs

“…Abstract Despite advances in molecular characterization of glioblastoma multiforme (GBM), only a handful of predictive biomarkers exist with limited clinical…”
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Resistance to Combined Anthracycline-Taxane Chemotherapy Is Associated with Altered Metabolism and Inflammation in Breast Carcinomas by Menyhárt, Otília, Fekete, János Tibor, Győrffy, Balázs

“…Approximately 30% of early-stage breast cancer (BC) patients experience recurrence after systemic chemotherapy; thus, understanding therapy resistance is…”
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Molecular markers and potential therapeutic targets in non-WNT/non-SHH (group 3 and group 4) medulloblastomas by Menyhárt, Otília, Giangaspero, Felice, Győrffy, Balázs

“…Childhood medulloblastomas (MB) are heterogeneous and are divided into four molecular subgroups. The provisional non-wingless-activated (WNT)/non-sonic…”
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Inflammation and Colorectal Cancer: A Meta-Analysis of the Prognostic Significance of the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI) by Menyhart, Otilia, Fekete, János Tibor, Győrffy, Balázs

“…The overall prognosis for colorectal cancer (CRC) remains challenging as the survival time varies widely, even in patients with the same stage of disease…”
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Gene Expression Indicates Altered Immune Modulation and Signaling Pathway Activation in Ovarian Cancer Patients Resistant to Topotecan by Menyhárt, Otília, Fekete, János Tibor, Győrffy, Balázs

“…Epithelial ovarian cancer (EOC) is one of the deadliest gynecological malignancies. Topotecan remains an essential tool in second-line therapy; even so, most…”
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The prognostic association of SPAG5 gene expression in breast cancer patients with systematic therapy by Zhu, Chenjing, Menyhart, Otilia, Győrffy, Balázs, He, Xia

“…Despite much effort on the treatment of breast cancer over the decades, a great uncertainty regarding the appropriate molecular biomarkers and optimal…”
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Mutations Defining Patient Cohorts With Elevated PD-L1 Expression in Gastric Cancer by Menyhárt, Otília, Pongor, Lőrinc Sándor, Győrffy, Balázs

“…The immunotherapy agent pembrolizumab has been approved for gastric cancer (GC) patients with recurrent or advanced disease who are PD-L1 positive. Mutations…”
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Principles of tumorigenesis and emerging molecular drivers of SHH‐activated medulloblastomas by Menyhárt, Otília, Győrffy, Balázs

“…SHH‐activated medulloblastomas (SHH‐MB) account for 25–30% of all medulloblastomas (MB) and occur with a bimodal age distribution, encompassing many infant and…”
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Demographic shift disproportionately increases cancer burden in an aging nation: current and expected incidence and mortality in Hungary up to 2030 by Menyhárt, Otília, Fekete, János T, Győrffy, Balázs

“…Population aging is a common demographic pattern in developed countries, and aging increases the risk of cancer. The disproportionately high cancer burden, as…”
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Propagation on Molecular Interaction Networks: Prediction of Effective Drug Combinations and Biomarkers in Cancer Treatment by Ligeti, Balazs, Menyhart, Otilia, Petric, Ingrid, Gyorffy, Balazs, Pongor, Sandor

“…Biomedical sciences use a variety of data sources on drug molecules, genes, proteins, diseases and scientific publications etc. This system can be best…”
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