Search Results - "Menyhart, Daniel"

Development of a potent and selective chemical probe for the pleiotropic kinase CK2 by Wells, Carrow I, Drewry, David H, Pickett, Julie E, Tjaden, Amelie, Krämer, Andreas, Müller, Susanne, Gyenis, Laszlo, Menyhart, Daniel, Litchfield, David W, Knapp, Stefan, Axtman, Alison D

“…Building on the pyrazolopyrimidine CK2 (casein kinase 2) inhibitor scaffold, we designed a small targeted library. Through comprehensive evaluation of…”
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Chemical Genetic Validation of CSNK2 Substrates Using an Inhibitor-Resistant Mutant in Combination with Triple SILAC Quantitative Phosphoproteomics by Gyenis, Laszlo, Menyhart, Daniel, Cruise, Edward S, Jurcic, Kristina, Roffey, Scott E, Chai, Darren B, Trifoi, Flaviu, Fess, Sam R, Desormeaux, Paul J, Núñez de Villavicencio Díaz, Teresa, Rabalski, Adam J, Zukowski, Stephanie A, Turowec, Jacob P, Pittock, Paula, Lajoie, Gilles, Litchfield, David W

“…Casein Kinase 2 (CSNK2) is an extremely pleiotropic, ubiquitously expressed protein kinase involved in the regulation of numerous key biological processes…”
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Towards the CSNK2 phosphoproteome – With lessons from the COVID-19 pandemic to revealing the secrets of CSNK2 and its promise as a therapeutic target by Litchfield, David W., Gyenis, Laszlo, Menyhart, Daniel, Roffey, Scott E.

“…Dramatic advances in phosphoproteomics and the development of a selective chemical probe have presented new opportunities for revealing the cellular landscape…”
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