Search Results - "Menyhart, Akos"

Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions by Császár, Eszter, Lénárt, Nikolett, Cserép, Csaba, Környei, Zsuzsanna, Fekete, Rebeka, Pósfai, Balázs, Balázsfi, Diána, Hangya, Balázs, Schwarcz, Anett D, Szabadits, Eszter, Szöllősi, Dávid, Szigeti, Krisztián, Máthé, Domokos, West, Brian L, Sviatkó, Katalin, Brás, Ana Rita, Mariani, Jean-Charles, Kliewer, Andrea, Lenkei, Zsolt, Hricisák, László, Benyó, Zoltán, Baranyi, Mária, Sperlágh, Beáta, Menyhárt, Ákos, Farkas, Eszter, Dénes, Ádám

“…Microglia, the main immunocompetent cells of the brain, regulate neuronal function, but their contribution to cerebral blood flow (CBF) regulation has remained…”
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Collateral is brain: Low perfusion triggers spreading depolarization and futile reperfusion after acute ischemic stroke by Törteli, Anna, Tóth, Réka, Bari, Ferenc, Farkas, Eszter, Menyhárt, Ákos

“…Futile reperfusion is a phenomenon of inadequate perfusion despite successful recanalization after acute ischemic stroke (AIS). It is associated with poor…”
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Nimodipine accelerates the restoration of functional hyperemia during spreading oligemia by Menyhárt, Ákos, Bálint, Armand Rafael, Kozák, Péter, Bari, Ferenc, Farkas, Eszter

“…Spreading depolarization (SD) is assumed to be the pathophysiological correlate of migraine aura, leading to spreading depression of activity and a…”
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Spreading depolarization causes reperfusion failure after cerebral ischemia by Törteli, Anna, Tóth, Réka, Berger, Sarah, Samardzic, Sarah, Bari, Ferenc, Menyhárt, Ákos, Farkas, Eszter

“…Despite successful recanalization, reperfusion failure associated with poor neurological outcomes develops in half of treated stroke patients. We explore here…”
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Nimodipine augments cerebrovascular reactivity in aging but runs the risk of local perfusion reduction in acute cerebral ischemia by Kecskés, Szilvia, Menyhárt, Ákos, Bari, Ferenc, Farkas, Eszter

“…The efficacy of cerebrovascular reactivity (CVR) is taken as an indicator of cerebrovascular health. We found that CVR tested with the inhalation of 10 % CO…”
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Tissue Acidosis Associated with Ischemic Stroke to Guide Neuroprotective Drug Delivery by M Tóth, Orsolya, Menyhárt, Ákos, Frank, Rita, Hantosi, Dóra, Farkas, Eszter, Bari, Ferenc

“…Ischemic stroke is a leading cause of death and disability worldwide. Yet, the effective therapy of focal cerebral ischemia has been an unresolved challenge…”
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Nimodipine inhibits spreading depolarization, ischemic injury, and neuroinflammation in mouse live brain slice preparations by Frank, Rita, Szarvas, Péter Archibald, Pesti, István, Zsigmond, Anna, Berkecz, Róbert, Menyhárt, Ákos, Bari, Ferenc, Farkas, Eszter

“…Nimodipine is used to prevent delayed ischemic deficit in patients with aneurysmal subarachnoid hemorrhage (aSAH). Spreading depolarization (SD) is recognized…”
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Age or ischemia uncouples the blood flow response, tissue acidosis, and direct current potential signature of spreading depolarization in the rat brain by Menyhárt, Ákos, Zölei-Szénási, Dániel, Puskás, Tamás, Makra, Péter, Bari, Ferenc, Farkas, Eszter

“…Spreading depolarization (SD) events contribute to lesion maturation in the acutely injured human brain. Neurodegeneration related to SD is thought to be…”
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Susceptibility of the cerebral cortex to spreading depolarization in neurological disease states: The impact of aging by Hertelendy, Péter, Varga, Dániel P., Menyhárt, Ákos, Bari, Ferenc, Farkas, Eszter

“…Secondary injury following acute brain insults significantly contributes to poorer neurological outcome. The spontaneous, recurrent occurrence of spreading…”
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IGF‐1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging by Toth, Peter, Tarantini, Stefano, Ashpole, Nicole M., Tucsek, Zsuzsanna, Milne, Ginger L., Valcarcel‐Ares, Noa M., Menyhart, Akos, Farkas, Eszter, Sonntag, William E., Csiszar, Anna, Ungvari, Zoltan

“…Summary Aging is associated with marked deficiency in circulating IGF‐1, which has been shown to contribute to age‐related cognitive decline. Impairment of…”
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Large-conductance Ca2+-activated potassium channels are potently involved in the inverse neurovascular response to spreading depolarization by Menyhárt, Ákos, Farkas, Attila E., Varga, Dániel P., Frank, Rita, Tóth, Réka, Bálint, Armand R., Makra, Péter, Dreier, Jens P., Bari, Ferenc, Krizbai, István A., Farkas, Eszter

“…Recurrent spreading depolarizations occur in the cerebral cortex from minutes up to weeks following acute brain injury. Clinical evidence suggests that the…”
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N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain by Szabó, Írisz, Varga, Viktória É., Dvorácskó, Szabolcs, Farkas, Attila E., Körmöczi, Tímea, Berkecz, Róbert, Kecskés, Szilvia, Menyhárt, Ákos, Frank, Rita, Hantosi, Dóra, Cozzi, Nicholas V., Frecska, Ede, Tömböly, Csaba, Krizbai, István A., Bari, Ferenc, Farkas, Eszter

“…Dimethyltryptamine (DMT), an endogenous ligand of sigma-1 receptors (Sig-1Rs), acts against systemic hypoxia, but whether DMT may prevent cerebral ischemic…”
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Chitosan nanoparticles release nimodipine in response to tissue acidosis to attenuate spreading depolarization evoked during forebrain ischemia by Tóth, Orsolya M., Menyhárt, Ákos, Varga, Viktória Éva, Hantosi, Dóra, Ivánkovits-Kiss, Orsolya, Varga, Dániel Péter, Szabó, Írisz, Janovák, László, Dékány, Imre, Farkas, Eszter, Bari, Ferenc

“…Stroke is an important cause of mortality and disability. Treatment options are limited, therefore the progress in this regard is urgently needed. Nimodipine,…”
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Microglia alter the threshold of spreading depolarization and related potassium uptake in the mouse brain by Varga, Dániel P, Menyhárt, Ákos, Pósfai, Balázs, Császár, Eszter, Lénárt, Nikolett, Cserép, Csaba, Orsolits, Barbara, Martinecz, Bernadett, Szlepák, Tamás, Bari, Ferenc, Farkas, Eszter, Dénes, Ádám

“…Selective elimination of microglia from the brain was shown to dysregulate neuronal Ca2+ signaling and to reduce the incidence of spreading depolarization (SD)…”
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Astrocyte Ca2+ Waves and Subsequent Non-Synchronized Ca2+ Oscillations Coincide with Arteriole Diameter Changes in Response to Spreading Depolarization by Tóth, Réka, Farkas, Attila E., Krizbai, István A., Makra, Péter, Bari, Ferenc, Farkas, Eszter, Menyhárt, Ákos

“…Spreading depolarization (SD) is a wave of mass depolarization that causes profound perfusion changes in acute cerebrovascular diseases. Although the astrocyte…”
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Transient Hypoperfusion to Ischemic/Anoxic Spreading Depolarization is Related to Autoregulatory Failure in the Rat Cerebral Cortex by Menyhárt, Ákos, Varga, Dániel Péter, M. Tóth, Orsolya, Makra, Péter, Bari, Ferenc, Farkas, Eszter

“…Background In ischemic stroke, cerebral autoregulation and neurovascular coupling may become impaired. The cerebral blood flow (CBF) response to spreading…”
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Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci by Menyhárt, Ákos, Frank, Rita, Farkas, Attila E, Süle, Zoltán, Varga, Viktória É, Nyúl-Tóth, Ádám, Meiller, Anne, Ivánkovits-Kiss, Orsolya, Lemale, Coline L, Szabó, Írisz, Tóth, Réka, Zölei-Szénási, Dániel, Woitzik, Johannes, Marinesco, Stephane, Krizbai, István A, Bari, Ferenc, Dreier, Jens P, Farkas, Eszter

“…Spreading depolarizations (SDs) indicate injury progression and predict worse clinical outcome in acute brain injury. We demonstrate in rodents that acute…”
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Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain by Menyhárt, Ákos, Zölei-Szénási, Dániel, Puskás, Tamás, Makra, Péter, Orsolya, M. Tóth, Szepes, Borbála É., Tóth, Réka, Ivánkovits-Kiss, Orsolya, Obrenovitch, Tihomir P., Bari, Ferenc, Farkas, Eszter

“…Spreading depolarizations (SDs) occur spontaneously in the cerebral cortex of subarachnoid hemorrhage, stroke or traumatic brain injury patients. Accumulating…”
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The impact of dihydropyridine derivatives on the cerebral blood flow response to somatosensory stimulation and spreading depolarization by Szabó, Írisz, M. Tóth, Orsolya, Török, Zsolt, Varga, Dániel Péter, Menyhárt, Ákos, Frank, Rita, Hantosi, Dóra, Hunya, Ákos, Bari, Ferenc, Horváth, Ibolya, Vigh, László, Farkas, Eszter

“…Background and Purpose A new class of dihydropyridine derivatives, which act as co‐inducers of heat shock protein but are devoid of calcium channel antagonist…”
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High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain by Menyhárt, Ákos, Makra, Péter, Szepes, Borbála É, Tóth, Orsolya M, Hertelendy, Péter, Bari, Ferenc, Farkas, Eszter

“…Abstract Spreading depolarizations (SDs) occur spontaneously in the brain after stroke, exacerbate ischemic injury, and thus emerge as a potential target of…”
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