Search Results - "Menyhárt, Ákos"
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Spectral and Multifractal Signature of Cortical Spreading Depolarisation in Aged Rats
Published in Frontiers in physiology (08-11-2018)“…Cortical spreading depolarisation (CSD) is a transient disruption of ion balance that propagates along the cortex. It has been identified as an important…”
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2
REPERFUSION FAILURE AFTER SPREADING DEPOLARIZATION SHAPES HEMOGLOBIN CONTENT IN THE MOUSE CORTEX
Published in IBRO neuroscience reports (01-10-2023)Get full text
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3
Comparative analysis of spreading depolarizations in brain slices exposed to osmotic or metabolic stress
Published in BMC neuroscience (03-05-2021)“…Recurrent spreading depolarizations (SDs) occur in stroke and traumatic brain injury and are considered as a hallmark of injury progression. The complexity of…”
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4
Nimodipine exerts a protective effect against spreading depolarization and neuroinflammation
Published in Physiology (Bethesda, Md.) (01-05-2023)“…Abstract only Hypothesis, objective: Voltage gated Ca2+ channels (VGCCs) are widely expressed in the central nervous system and implicated in neuronal injury…”
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5
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions
Published in The Journal of experimental medicine (07-03-2022)“…Microglia, the main immunocompetent cells of the brain, regulate neuronal function, but their contribution to cerebral blood flow (CBF) regulation has remained…”
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Collateral is brain: Low perfusion triggers spreading depolarization and futile reperfusion after acute ischemic stroke
Published in Journal of cerebral blood flow and metabolism (01-10-2024)“…Futile reperfusion is a phenomenon of inadequate perfusion despite successful recanalization after acute ischemic stroke (AIS). It is associated with poor…”
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7
Nimodipine accelerates the restoration of functional hyperemia during spreading oligemia
Published in Journal of neurochemistry (01-05-2024)“…Spreading depolarization (SD) is assumed to be the pathophysiological correlate of migraine aura, leading to spreading depression of activity and a…”
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8
Spreading depolarization causes reperfusion failure after cerebral ischemia
Published in Journal of cerebral blood flow and metabolism (01-05-2023)“…Despite successful recanalization, reperfusion failure associated with poor neurological outcomes develops in half of treated stroke patients. We explore here…”
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Nimodipine augments cerebrovascular reactivity in aging but runs the risk of local perfusion reduction in acute cerebral ischemia
Published in Frontiers in aging neuroscience (27-04-2023)“…The efficacy of cerebrovascular reactivity (CVR) is taken as an indicator of cerebrovascular health. We found that CVR tested with the inhalation of 10 % CO…”
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10
Tissue Acidosis Associated with Ischemic Stroke to Guide Neuroprotective Drug Delivery
Published in Biology (Basel, Switzerland) (11-12-2020)“…Ischemic stroke is a leading cause of death and disability worldwide. Yet, the effective therapy of focal cerebral ischemia has been an unresolved challenge…”
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11
Astrocyte Ca 2+ Waves and Subsequent Non-Synchronized Ca 2+ Oscillations Coincide with Arteriole Diameter Changes in Response to Spreading Depolarization
Published in International journal of molecular sciences (26-03-2021)“…Spreading depolarization (SD) is a wave of mass depolarization that causes profound perfusion changes in acute cerebrovascular diseases. Although the astrocyte…”
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12
Potentials and limitations of nanomedicine in the treatment of stroke patients
Published in Orvosi hetilap (08-09-2024)Get more information
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13
The Impact of Aging on Spreading Depolarization in the Intact and Ischemic Rat Brain
Published 01-01-2017“…Background: Aging emerges as a major independent risk factor for the incidence and prevalence of ischemic stroke and predicts poor patient outcomes 41, 42 . In…”
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Dissertation -
14
Nimodipine inhibits spreading depolarization, ischemic injury, and neuroinflammation in mouse live brain slice preparations
Published in European journal of pharmacology (15-08-2024)“…Nimodipine is used to prevent delayed ischemic deficit in patients with aneurysmal subarachnoid hemorrhage (aSAH). Spreading depolarization (SD) is recognized…”
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15
Age or ischemia uncouples the blood flow response, tissue acidosis, and direct current potential signature of spreading depolarization in the rat brain
Published in American journal of physiology. Heart and circulatory physiology (01-08-2017)“…Spreading depolarization (SD) events contribute to lesion maturation in the acutely injured human brain. Neurodegeneration related to SD is thought to be…”
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16
Susceptibility of the cerebral cortex to spreading depolarization in neurological disease states: The impact of aging
Published in Neurochemistry international (01-07-2019)“…Secondary injury following acute brain insults significantly contributes to poorer neurological outcome. The spontaneous, recurrent occurrence of spreading…”
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17
IGF‐1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging
Published in Aging cell (01-12-2015)“…Summary Aging is associated with marked deficiency in circulating IGF‐1, which has been shown to contribute to age‐related cognitive decline. Impairment of…”
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Large-conductance Ca2+-activated potassium channels are potently involved in the inverse neurovascular response to spreading depolarization
Published in Neurobiology of disease (01-11-2018)“…Recurrent spreading depolarizations occur in the cerebral cortex from minutes up to weeks following acute brain injury. Clinical evidence suggests that the…”
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N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain
Published in Neuropharmacology (01-07-2021)“…Dimethyltryptamine (DMT), an endogenous ligand of sigma-1 receptors (Sig-1Rs), acts against systemic hypoxia, but whether DMT may prevent cerebral ischemic…”
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Chitosan nanoparticles release nimodipine in response to tissue acidosis to attenuate spreading depolarization evoked during forebrain ischemia
Published in Neuropharmacology (01-01-2020)“…Stroke is an important cause of mortality and disability. Treatment options are limited, therefore the progress in this regard is urgently needed. Nimodipine,…”
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