Search Results - "Menssen, Antje"

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions by Siemens, Helge, Jackstadt, Rene, Hünten, Sabine, Kaller, Markus, Menssen, Antje, Götz, Ursula, Hermeking, Heiko

“…Recently, the inhibition of epithelial-mesenchymal-transition (EMT) by p53 has been described as a new mode of tumor suppression which presumably prevents…”
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AP4 Encodes a c-MYC-Inducible Repressor of p21 by Jung, Peter, Menssen, Antje, Mayr, Doris, Hermeking, Heiko

“…In the majority of human tumors, expression of the c-MYC oncogene becomes constitutive. Here, we report that c-MYC directly regulates the expression of AP4 via…”
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The c-MYC oncoprotein, the NAMPT enzyme, SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop by Menssen, Antje, Hydbring, Per, Kapelle, Karsten, Vervoorts, Jörg, Diebold, Joachim, Lüscher, Bernhard, Larsson, Lars-Gunnar, Hermeking, Heiko

“…Silent information regulator 1 (SIRT1) represents an NAD + -dependent deacetylase that inhibits proapoptotic factors including p53. Here we determined whether…”
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AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer by Jackstadt, Rene, Röh, Simone, Neumann, Jens, Jung, Peter, Hoffmann, Reinhard, Horst, David, Berens, Christian, Bornkamm, Georg W, Kirchner, Thomas, Menssen, Antje, Hermeking, Heiko

“…The basic helix-loop-helix transcription factor AP4/TFAP4/AP-4 is encoded by a c-MYC target gene and displays up-regulation concomitantly with c-MYC in…”
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Characterization of the c-MYC-Regulated Transcriptome by SAGE: Identification and Analysis of c-MYC Target Genes by Menssen, Antje, Hermeking, Heiko

“…To identify target genes of the oncogenic transcription factor c-MYC, serial analysis of gene expression (SAGE) was performed after adenoviral expression of…”
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Functional epigenomics identifies genes frequently silenced in prostate cancer by LODYGIN, Dimitri, EPANCHINTSEV, Alexey, MENSSEN, Antje, DIEBOLD, Joachim, HERMEKING, Heiko

“…In many cases, silencing of gene expression by CpG methylation is causally involved in carcinogenesis. Furthermore, cancer-specific CpG methylation may serve…”
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Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis by Brandl, Lydia, Zhang, Yina, Kirstein, Nina, Sendelhofert, Andrea, Boos, Sophie Luise, Jung, Peter, Greten, Florian, Rad, Roland, Menssen, Antje

“…We recently described a positive feedback loop connecting c-MYC, NAMPT, DBC1 and SIRT1 that contributes to unrestricted cancer cell proliferation. Here we…”
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Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin by Brandl, Lydia, Hartmann, Daniela, Kirchner, Thomas, Menssen, Antje

“…Deregulated Hedgehog signalling is a driver of basal cell carcinomas. One effector of the Hedgehog pathway is n-MYC. c/n-MYC proteins, NAMPT and DBC1 are…”
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Large-Scale Identification of c-MYC-Associated Proteins Using a Combined TAP/MudPIT Approach by Koch, Heike, Zhang, Ru, Verdoodt, Berlinda, Bailey, Aaron, Zhang, Chang-Dong, Yates, John R., Menssen, Antje, Hermeking, Heiko

“…The c-MYC oncogene encodes a transcription factor, which is sufficient and necessary for the induction of cellular proliferation. However, the c-MYC protein is…”
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c-MYC Delays Prometaphase by Direct Transactivation of MAD2 and BubR1: Identification of Mechanisms Underlying c-MYC-Induced DNA Damage and Chromosomal Instability by Menssen, Antje, Epanchintsev, Alexey, Lodygin, Dmitri, Rezaei, Nousin, Jung, Peter, Verdoodt, Berlinda, Diebold, Joachim, Hermeking, Heiko

“…Here we show that the human BubR1 and MAD2 genes, which encode inhibitors of the anaphase promoting complex (APC/C), are directly activated by the oncogenic…”
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Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner by Lodygin, Dimitri, Menssen, Antje, Hermeking, Heiko

“…Using microarray analysis, we have detected downregulation of several components of the cGMP signaling pathway during replicative senescence of primary human…”
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OTT-MAL Is a Deregulated Activator of Serum Response Factor-Dependent Gene Expression by Descot, Arnaud, Rex-Haffner, Monika, Courtois, Geneviève, Bluteau, Dominique, Menssen, Antje, Mercher, Thomas, Bernard, Olivier A., Treisman, Richard, Posern, Guido

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Induction of Cullin 7 by DNA damage attenuates p53 function by Jung, Peter, Verdoodt, Berlinda, Bailey, Aaron, Yates, John R. III, Menssen, Antje, Hermeking, Heiko

“…The p53 tumor suppressor gene encodes a transcription factor, which is translationally and posttranslationally activated after DNA damage. In a proteomic…”
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Digital Karyotyping Reveals Frequent Inactivation of the dystrophin/DMD Gene in Malignant Melanoma by Körner, Henrike, Epanchintsev, Alexey, Berking, Carola, Schuler-Thurner, Beatrice, Speicher, Michael R., Menssen, Antje, Hermeking, Heiko

“…Malignant melanoma is still poorly understood at the genomic level. Recently, a new technique for the high-resolution analysis of copy number changes named…”
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Differential Regulation of microRNAs by p53 Revealed by Massively Parallel Sequencing: miR-34a is a p53 Target That Induces Apoptosis and G1-arrest by Tarasov, Valery, Jung, Peter, Verdoodt, Berlinda, Lodygin, Dmitri, Epanchintsev, Alexey, Menssen, Antje, Meister, Gunter, Hermeking, Heiko

“…In a genome-wide screen for microRNAs regulated by the transcription factor encoded by the p53 tumor suppressor gene we found that after p53-activation the…”
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Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer by Kriegl, Lydia, Vieth, Michael, Kirchner, Thomas, Menssen, Antje

“…Approximately 7.5% of all colorectal cancers are considered to originate from the alternative, serrated route. Here, we investigate the expression of the c-MYC…”
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c-MYC and SIRT1 locked in a vicious cycle by Menssen, Antje, Hermeking, Heiko

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The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target by Brandl, Lydia, Kirstein, Nina, Neumann, Jens, Sendelhofert, Andrea, Vieth, Michael, Kirchner, Thomas, Menssen, Antje

“…We have recently identified a positive feedback loop in which c-MYC increases silent information regulator 1 (SIRT1) protein level and activity through…”
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Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis1 by Brandl, Lydia, Zhang, Yina, Kirstein, Nina, Sendelhofert, Andrea, Boos, Sophie Luise, Jung, Peter, Greten, Florian, Rad, Roland, Menssen, Antje

“…We recently described a positive feedback loop connecting c-MYC, NAMPT, DBC1 and SIRT1 that contributes to unrestricted cancer cell proliferation. Here we…”
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Digoxin inhibits development of hypoxic pulmonary hypertension in mice by Abud, Edsel M, Maylor, Julie, Undem, Clark, Punjabi, Arjun, Zaiman, Ari L, Myers, Allen C, Sylvester, J. T, Semenza, Gregg L, Shimoda, Larissa A

“…Chronic hypoxia is an inciting factor for the development of pulmonary arterial hypertension. The mechanisms involved in the development of hypoxic pulmonary…”
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